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pro vyhledávání: '"Garoff, Linnéa"'
Akademický článek
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Publikováno v:
Journal of Antimicrobial Chemotherapy
Background Ribosomal protection proteins (RPPs) interact with bacterial ribosomes to prevent inhibition of protein synthesis by tetracycline. RPP genes have evolved from a common ancestor into at least 12 distinct classes and spread by horizontal gen
Autor:
Brandis, Gerrit, Granström, Susanna, Leber, Anna T, Bartke, Katrin, Garoff, Linnéa, Cao, Sha, Huseby, Douglas L, Hughes, Diarmaid
Publikováno v:
Journal of Antimicrobial Chemotherapy
Background Mutations in RNA polymerase (RNAP) can reduce susceptibility to ciprofloxacin in Escherichia coli, but the mechanism of transcriptional reprogramming responsible is unknown. Strains carrying ciprofloxacin-resistant (CipR) rpoB mutations ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6bc674d1599c87b150dc7fc3863f51b4
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-440090
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-440090
Publikováno v:
Journal of Antimicrobial Chemotherapy
Background The qepA1 gene encodes an efflux pump that reduces susceptibility to ciprofloxacin. Little is known about the regulation of qepA1 expression. Objectives To assess the potential role of ciprofloxacin and other antibiotics in the regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3ca89cbc5d442b59cd1ecf3da3323dc7
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-447096
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-447096
Publikováno v:
Molecular Biology and Evolution
Integration of a conjugative plasmid into a bacterial chromosome can promote the transfer of chromosomal DNA to other bacteria. Intraspecies chromosomal conjugation is believed responsible for creating the global pathogens Klebsiella pneumoniae ST258
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fe0e58da434dd2e10bb4b32ffe82450e
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-446848
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-446848
Autor:
Garoff, Linnéa, Pietsch, Franziska, Huseby, Douglas L, Lilja, Tua, Brandis, Gerrit, Hughes, Diarmaid
Publikováno v:
Molecular Biology and Evolution
Experimental evolution is a powerful tool to study genetic trajectories to antibiotic resistance under selection. A confounding factor is that outcomes may be heavily influenced by the choice of experimental parameters. For practical purposes (minimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::730f204cdb9dfa564b7a35e00dd3fd8a
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-422798
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-422798
Effect of aminoacyl-tRNA synthetase mutations on susceptibility to ciprofloxacin in Escherichia coli
Background: Chromosomal mutations that reduce ciprofloxacin susceptibility in Escherichia coli characteristically map to drug target genes (gyrAB and parCE), and genes encoding regulators of the AcrAB-TolC efflux pump. Mutations in RNA polymerase can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::fd5f326e47c4a8318a41de6627a2d8f3
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-361197
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-361197
Autor:
Garoff, Linnéa
This thesis presents an exploration of the resistance evolution in Escherichia coli towards the antibiotic ciprofloxacin. High level ciprofloxacin resistance is typically acquired by an accumulation of mutations and plasmid borne genes reducing drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::85d8d6ba58e9f8d19f005cdcdac1cf55
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-361204
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-361204
Mutation supply and relative fitness shape the genotypes of ciprofloxacin-resistant Escherichia coli
Autor:
Huseby, Douglas L., Pietsch, Franziska, Brandis, Gerrit, Garoff, Linnéa, Tegehall, Angelica, Hughes, Diarmaid
Ciprofloxacin is an important antibacterial drug targeting Type II topoisomerases, highly active against Gram-negatives including Escherichia coli. The evolution of resistance to ciprofloxacin in E. coli always requires multiple genetic changes, usua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8f9061cd5fdee57f786083861b873f38
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-264874
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-264874
Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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