Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa .

Autor: Cotman AE; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia., Durcik M; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia., Benedetto Tiz D; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia., Fulgheri F; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia., Secci D; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia., Sterle M; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia., Možina Š; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia., Skok Ž; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia., Zidar N; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia., Zega A; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia., Ilaš J; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia., Peterlin Mašič L; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia., Tomašič T; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia., Hughes D; Department of Medical Biochemistry and Microbiology, Uppsala University, Husargatan 3, 75123 Uppsala, Sweden., Huseby DL; Department of Medical Biochemistry and Microbiology, Uppsala University, Husargatan 3, 75123 Uppsala, Sweden., Cao S; Department of Medical Biochemistry and Microbiology, Uppsala University, Husargatan 3, 75123 Uppsala, Sweden., Garoff L; Department of Medical Biochemistry and Microbiology, Uppsala University, Husargatan 3, 75123 Uppsala, Sweden., Berruga Fernández T; Department of Medical Biochemistry and Microbiology, Uppsala University, Husargatan 3, 75123 Uppsala, Sweden., Giachou P; Department of Medical Biochemistry and Microbiology, Uppsala University, Husargatan 3, 75123 Uppsala, Sweden., Crone L; Department of Medical Biochemistry and Microbiology, Uppsala University, Husargatan 3, 75123 Uppsala, Sweden., Simoff I; Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Department of Pharmacy, Uppsala University, Husargatan 3, 75123 Uppsala, Sweden., Svensson R; Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Department of Pharmacy, Uppsala University, Husargatan 3, 75123 Uppsala, Sweden., Birnir B; Department of Medical Cell Biology, Uppsala University, Husargatan 3, 75123 Uppsala, Sweden., Korol SV; Department of Medical Cell Biology, Uppsala University, Husargatan 3, 75123 Uppsala, Sweden., Jin Z; Department of Medical Cell Biology, Uppsala University, Husargatan 3, 75123 Uppsala, Sweden., Vicente F; Fundación MEDINA, Avenida del Conocimiento 34, Parque Tecnológico Ciencias de la Salud, 18016 Granada, Spain., Ramos MC; Fundación MEDINA, Avenida del Conocimiento 34, Parque Tecnológico Ciencias de la Salud, 18016 Granada, Spain., de la Cruz M; Fundación MEDINA, Avenida del Conocimiento 34, Parque Tecnológico Ciencias de la Salud, 18016 Granada, Spain., Glinghammar B; Department Chemical Process and Pharmaceutical Development, Unit Chemical and Pharmaceutical Safety, RISE Research Institutes of Sweden, 15136 Södertälje, Sweden., Lenhammar L; Department of Medical Sciences, Uppsala University Hospital, 75185 Uppsala, Sweden., Henderson SR; Department of Biochemistry and Metabolism, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, U.K., Mundy JEA; Department of Biochemistry and Metabolism, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, U.K., Maxwell A; Department of Biochemistry and Metabolism, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, U.K., Stevenson CEM; Department of Biochemistry and Metabolism, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, U.K., Lawson DM; Department of Biochemistry and Metabolism, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, U.K., Janssen GV; Medicinal Chemistry Division, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands., Sterk GJ; Medicinal Chemistry Division, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands., Kikelj D; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Jan 26; Vol. 66 (2), pp. 1380-1425. Date of Electronic Publication: 2023 Jan 12.

Expression of the qepA1 gene is induced under antibiotic exposure.

Autor: Brandis G; Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Box 582, Uppsala, Sweden., Gockel J; Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Box 582, Uppsala, Sweden., Garoff L; Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Box 582, Uppsala, Sweden., Guy L; Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Box 582, Uppsala, Sweden., Hughes D; Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Box 582, Uppsala, Sweden.

Publikováno v: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2021 May 12; Vol. 76 (6), pp. 1433-1440.

Occurrence and characterization of plasmid-encoded qnr genes in quinolone-resistant bacteria across diverse aquatic environments in southern Ontario.

Autor: Yusuf, Farhan¹ (AUTHOR), Ahmed, Saher M.² (AUTHOR), Dy, Danica³ (AUTHOR), Baney, Katherine⁴ (AUTHOR), Waseem, Hassan¹ (AUTHOR), Gilbride, Kimberley A.^1,2 (AUTHOR) gilbride@torontomu.ca

Publikováno v: Canadian Journal of Microbiology. 2024, Vol. 70 Issue 11, p492-506. 15p.

Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli.

Autor: Garoff L; Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Uppsala, Sweden., Pietsch F; Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Uppsala, Sweden., Huseby DL; Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Uppsala, Sweden., Lilja T; Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Uppsala, Sweden., Brandis G; Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Uppsala, Sweden., Hughes D; Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Uppsala, Sweden.

Publikováno v: Molecular biology and evolution [Mol Biol Evol] 2020 Jun 01; Vol. 37 (6), pp. 1637-1646.

Effect of aminoacyl-tRNA synthetase mutations on susceptibility to ciprofloxacin in Escherichia coli.

Autor: Garoff L; Uppsala University, Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala, Sweden., Huseby DL; Uppsala University, Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala, Sweden., Praski Alzrigat L; Uppsala University, Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala, Sweden., Hughes D; Uppsala University, Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala, Sweden.

Publikováno v: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2018 Dec 01; Vol. 73 (12), pp. 3285-3292.