In vitro antiplasmodium and antitrypanosomal activities, β-haematin formation inhibition, molecular docking and DFT computational studies of quinoline-urea-benzothiazole hybrids.

Autor: Oyeneyin OE; School of Chemistry and Physics, University of KwaZulu Natal, Westville Campus, Durban, 4000, South Africa.; Department of Chemical Sciences, Adekunle Ajasin University, Akungba-Akoko, Ondo State, Nigeria., Moodley R; School of Chemistry and Physics, University of KwaZulu Natal, Westville Campus, Durban, 4000, South Africa., Mashaba C; School of Chemistry and Physics, University of KwaZulu Natal, Westville Campus, Durban, 4000, South Africa., Garnie LF; Department of Chemistry, Faculty of Science, University of Cape Town, Rondebosch, Cape Town, 7700, South Africa., Omoboyowa DA; Department of Biochemistry, Adekunle Ajasin University, Akungba-Akoko, Ondo State, Nigeria., Rakodi GH; Department of Chemistry, Faculty of Science, Tshwane University of Technology, Pretoria, 001, South Africa., Maphoru MV; Department of Chemistry, Faculty of Science, Tshwane University of Technology, Pretoria, 001, South Africa., Balogun MO; Bio-Polymer Modification and Therapeutics Laboratory, Council for Scientific and Industrial Research (CSIR), Pretoria, 0001, South Africa., Hoppe HC; Centre for Chemico- and Biomedical Research, Rhodes University, Makhanda, 6140, South Africa.; Department of Biochemistry and Microbiology, Faculty of Science, Rhodes University, Makhanda, 6140, South Africa., Egan TJ; Department of Chemistry, Faculty of Science, University of Cape Town, Rondebosch, Cape Town, 7700, South Africa.; Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Rondebosch, 7701, South Africa., Tukulula M; School of Chemistry and Physics, University of KwaZulu Natal, Westville Campus, Durban, 4000, South Africa.

Publikováno v: Heliyon [Heliyon] 2024 Sep 28; Vol. 10 (19), pp. e38434. Date of Electronic Publication: 2024 Sep 28 (Print Publication: 2024).

2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of Plasmodium falciparum Phosphatidylinositol-4-kinase and Hemozoin Formation with In Vivo Efficacy.

Autor: Dziwornu GA; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa., Seanego D; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa., Fienberg S; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa., Clements M; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa., Ferreira J; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa., Sypu VS; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa., Samanta S; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa., Bhana AD; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa., Korkor CM; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa., Garnie LF; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa., Teixeira N; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa., Wicht KJ; Drug Discovery and Development Centre (H3D), Department of Chemistry and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa., Taylor D; Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory 7925, South Africa., Olckers R; Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory 7925, South Africa., Njoroge M; Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory 7925, South Africa., Gibhard L; Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory 7925, South Africa., Salomane N; Drug Discovery and Development Centre (H3D), Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town 7925, South Africa., Wittlin S; Swiss Tropical and Public Health Institute, Kreuzstrasse 2, 4123 Allschwil, Switzerland.; University of Basel, 4001 Basel, Switzerland., Mahato R; TCG Lifesciences, Kolkata, 700091, India., Chakraborty A; TCG Lifesciences, Kolkata, 700091, India., Sevilleno N; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, U.K., Coyle R; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, U.K., Lee MCS; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, U.K., Godoy LC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Pasaje CF; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Niles JC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Reader J; Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Hatfield, Pretoria 0028, South Africa., van der Watt M; Institute for Sustainable Malaria Control, University of Pretoria, Hatfield, Pretoria 0028, South Africa., Birkholtz LM; Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Hatfield, Pretoria 0028, South Africa., Bolscher JM; TropIQ Health Sciences, Transistorweg 5, 6534 AT Nijmegen, The Netherlands., de Bruijni MHC; TropIQ Health Sciences, Transistorweg 5, 6534 AT Nijmegen, The Netherlands., Coulson LB; Drug Discovery and Development Centre (H3D), Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town 7925, South Africa., Basarab GS; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.; Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory 7925, South Africa., Ghorpade SR; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa., Chibale K; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.; South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Jul 11; Vol. 67 (13), pp. 11401-11420. Date of Electronic Publication: 2024 Jun 25.