Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Garnett H. Kelsoe"'
Publikováno v:
The Journal of Immunology. 198:152.14-152.14
B cells undergo iterative rounds of proliferation, hypermutation and selection in the germinal centers (GCs) to generate high affinity, protective antibody. It is now thought that GC B cells with higher affinity BCRs acquire more antigen for processi
Autor:
Kaitlin Sawatzki, Sila Ataca, Akiko Watanabe, Masayuki Kuraoka, Emmanuel Walter, Garnett H. Kelsoe, Feng Feng, Thomas B Kepler
Publikováno v:
The Journal of Immunology. 196:146.12-146.12
Anthrax Vaccine Adsorbed (AVA) vaccination protects against anthrax infection by eliciting a neutralizing antibody response. However, protective antibody titers are not observed in human sera until at least three vaccinations have been administered o
Publikováno v:
The Journal of Immunology. 196:133.37-133.37
Generation of high-affinity and class-switched antibody requires the germinal center (GC) reaction after infection or immunization. Within the B-cell follicles of secondary lymphoid organs, the GC represents a sophisticated collaboration between anti
Autor:
Joel T Finney, Guang Yang, Masayuki Kuraoka, Takuya Nojima, Laurent Verkoczy, Daisuke Kitamura, Barton F Haynes, Garnett H Kelsoe
Publikováno v:
The Journal of Immunology. 196:146.16-146.16
An effective HIV-1 vaccine is likely to require induction of broadly neutralizing antibodies (bnAbs), which neutralize multiple HIV-1 strains. Generating HIV-1 bnAbs has been challenging due partly to a number of viral immune evasion mechanisms, incl