Engineering of Orally Available, Ultralong-Acting Insulin Analogues: Discovery of OI338 and OI320.

Autor: Kjeldsen TB; Novo Nordisk A/S, Global Research Technologies, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Hubálek F; Novo Nordisk A/S, Global Research Technologies, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Tagmose TM; Novo Nordisk A/S, Global Research Technologies, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Pridal L; Novo Nordisk A/S, Global Drug Discovery, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Refsgaard HHF; Novo Nordisk A/S, Global Drug Discovery, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Porsgaard T; Novo Nordisk A/S, Global Drug Discovery, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Gram-Nielsen S; Novo Nordisk A/S, Global Drug Discovery, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Hovgaard L; Novo Nordisk A/S, Global Research Technologies, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Valore H; Novo Nordisk A/S, CMC API Development, Brudelysvej 20, DK-2880 Bagsvaerd, Denmark., Münzel M; Novo Nordisk A/S, Global Research Technologies, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Hjørringgaard CU; Novo Nordisk A/S, Global Research Technologies, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Jeppesen CB; Novo Nordisk A/S, Global Drug Discovery, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Manfè V; Novo Nordisk A/S, Global Drug Discovery, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Hoeg-Jensen T; Novo Nordisk A/S, Global Research Technologies, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Ludvigsen S; Novo Nordisk A/S, Global Research Technologies, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Nielsen PK; Novo Nordisk A/S, Global Research Technologies, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Lautrup-Larsen I; Novo Nordisk A/S, Global Research Technologies, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Stidsen CE; Novo Nordisk A/S, Global Drug Discovery, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Wulff EM; Novo Nordisk A/S, Global Drug Discovery, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Garibay PW; Novo Nordisk A/S, Global Research Technologies, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Kodra JT; Novo Nordisk A/S, Global Research Technologies, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Nishimura E; Novo Nordisk A/S, Global Drug Discovery, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Madsen P; Novo Nordisk A/S, Global Research Technologies, Novo Nordisk Park, DK-2760 Maaloev, Denmark.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Jan 14; Vol. 64 (1), pp. 616-628. Date of Electronic Publication: 2020 Dec 28.

Molecular engineering of safe and efficacious oral basal insulin.

Autor: Hubálek F; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Refsgaard HHF; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Gram-Nielsen S; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Madsen P; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Nishimura E; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Münzel M; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Brand CL; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Stidsen CE; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Claussen CH; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Wulff EM; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Pridal L; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Ribel U; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Kildegaard J; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Porsgaard T; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Johansson E; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Steensgaard DB; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Hovgaard L; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Glendorf T; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Hansen BF; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Jensen MK; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Nielsen PK; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Ludvigsen S; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Rugh S; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Garibay PW; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Moore MC; Vanderbilt University, Nashville, TN, USA., Cherrington AD; Vanderbilt University, Nashville, TN, USA., Kjeldsen T; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark. ThK@novonordisk.com.

Publikováno v: Nature communications [Nat Commun] 2020 Jul 27; Vol. 11 (1), pp. 3746. Date of Electronic Publication: 2020 Jul 27.