Engineering of Orally Available, Ultralong-Acting Insulin Analogues: Discovery of OI338 and OI320.

Autor: Kjeldsen TB; Novo Nordisk A/S, Global Research Technologies, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Hubálek F; Novo Nordisk A/S, Global Research Technologies, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Tagmose TM; Novo Nordisk A/S, Global Research Technologies, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Pridal L; Novo Nordisk A/S, Global Drug Discovery, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Refsgaard HHF; Novo Nordisk A/S, Global Drug Discovery, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Porsgaard T; Novo Nordisk A/S, Global Drug Discovery, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Gram-Nielsen S; Novo Nordisk A/S, Global Drug Discovery, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Hovgaard L; Novo Nordisk A/S, Global Research Technologies, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Valore H; Novo Nordisk A/S, CMC API Development, Brudelysvej 20, DK-2880 Bagsvaerd, Denmark., Münzel M; Novo Nordisk A/S, Global Research Technologies, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Hjørringgaard CU; Novo Nordisk A/S, Global Research Technologies, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Jeppesen CB; Novo Nordisk A/S, Global Drug Discovery, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Manfè V; Novo Nordisk A/S, Global Drug Discovery, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Hoeg-Jensen T; Novo Nordisk A/S, Global Research Technologies, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Ludvigsen S; Novo Nordisk A/S, Global Research Technologies, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Nielsen PK; Novo Nordisk A/S, Global Research Technologies, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Lautrup-Larsen I; Novo Nordisk A/S, Global Research Technologies, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Stidsen CE; Novo Nordisk A/S, Global Drug Discovery, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Wulff EM; Novo Nordisk A/S, Global Drug Discovery, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Garibay PW; Novo Nordisk A/S, Global Research Technologies, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Kodra JT; Novo Nordisk A/S, Global Research Technologies, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Nishimura E; Novo Nordisk A/S, Global Drug Discovery, Novo Nordisk Park, DK-2760 Maaloev, Denmark., Madsen P; Novo Nordisk A/S, Global Research Technologies, Novo Nordisk Park, DK-2760 Maaloev, Denmark.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Jan 14; Vol. 64 (1), pp. 616-628. Date of Electronic Publication: 2020 Dec 28.

Molecular engineering of safe and efficacious oral basal insulin.

Autor: Hubálek F; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Refsgaard HHF; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Gram-Nielsen S; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Madsen P; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Nishimura E; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Münzel M; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Brand CL; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Stidsen CE; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Claussen CH; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Wulff EM; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Pridal L; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Ribel U; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Kildegaard J; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Porsgaard T; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Johansson E; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Steensgaard DB; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Hovgaard L; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Glendorf T; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Hansen BF; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Jensen MK; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Nielsen PK; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Ludvigsen S; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Rugh S; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Garibay PW; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark., Moore MC; Vanderbilt University, Nashville, TN, USA., Cherrington AD; Vanderbilt University, Nashville, TN, USA., Kjeldsen T; Novo Nordisk A/S, Novo Nordisk Park 1, 2760, Maaloev, Denmark. ThK@novonordisk.com.

Publikováno v: Nature communications [Nat Commun] 2020 Jul 27; Vol. 11 (1), pp. 3746. Date of Electronic Publication: 2020 Jul 27.

Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells.

Autor: Buenaventura, Teresa¹, Bitsi, Stavroula¹, Laughlin, William E.¹, Burgoyne, Thomas², Lyu, Zekun^1,3, Oqua, Affiong I.¹, Norman, Hannah¹, McGlone, Emma R.³, Klymchenko, Andrey S.⁴, JrCorrêa, Ivan R.⁵, Walker, Abigail⁶, Inoue, Asuka⁷, Hanyaloglu, Aylin⁶, Grimes, Jak^8,9, Koszegi, Zsombor^8,9, Calebiro, Davide^8,9, Rutter, Guy A.¹, Bloom, Stephen R.³, Jones, Ben³ ben.jones@imperial.ac.uk, Tomas, Alejandra¹ a.tomas-catala@imperial.ac.uk

Publikováno v: PLoS Biology. 8/20/2019, Vol. 17 Issue 8, p1-40. 40p. 1 Black and White Photograph, 7 Graphs.

Novel Small Molecule Glucagon-Like Peptide-1 Receptor Agonist Stimulates Insulin Secretion in Rodents and From Human Islets.

Autor: Sloop, Kyle W., Willard, Francis S., Brenner, Martin B., Ficorilli, James, Valasek, Kathleen, Showalter, Aaron D., Farb, Thomas B., Cao, Julia X. C., Cox, Amy L., Michael, M. Dodson, Sanfeliciano, Sonia Maria Gutierrez, Tebbe, Mark J., Coghlan, Michael J.

Publikováno v: Diabetes; Dec2010, Vol. 59 Issue 12, p3099-3107, 9p, 1 Diagram, 6 Graphs

Polymer-Protein Conjugates : From Pegylation and Beyond

Autor: Gianfranco Pasut, Samuel Zalipsky

Polymer–Protein Conjugates: From Pegylation and Beyond helps researchers by offering a unique reference and guide into this fascinating area. Sections cover the challenges surrounding the homogeneity of conjugates, their purity and polymer toxicity