Antibody Responses to SARS-CoV-2 mRNA Vaccines Are Detectable in Saliva

Autor: Thomas J. Ketas, Devidas Chaturbhuj, Victor M. Cruz Portillo, Erik Francomano, Encouse Golden, Sharanya Chandrasekhar, Gargi Debnath, Randy Diaz-Tapia, Anila Yasmeen, Kyle D. Kramer, Tarek Munawar, Wilhem Leconet, Zhen Zhao, Philip J.M. Brouwer, Melissa M. Cushing, Rogier W. Sanders, Albert Cupo, P.J. Klasse, Silvia C. Formenti, John P. Moore

Publikováno v: Pathogens and Immunity, Vol 6, Iss 1 (2021)

The approved Pfizer and Moderna mRNA vaccines are well known to induce serum antibody responses to the SARS-CoV-2 Spike (S)-protein. However, their abilities to elicit mucosal immune responses have not been reported. Saliva antibodies represent mucos

Externí odkaz: https://doaj.org/article/e713a3a090fc4fe493126bb76a32e1a3

Antibody responses to SARS-CoV-2 mRNA vaccines are detectable in saliva

Autor: Rogier W. Sanders, Kyle D Kramer, Thomas J. Ketas, Tarek Munawar, Devidas Chaturbhuj, Gargi Debnath, Wilhelm Leconet, Erik Francomano, Sharanya Chandrasekhar, John P. Moore, Albert Cupo, Philip J. M. Brouwer, Melissa M. Cushing, Randy Diaz-Tapia, Zhen Zhao, Per Johan Klasse, Victor M. Cruz Portillo, Encouse B. Golden, Silvia C. Formenti, Anila Yasmeen

Publikováno v: Pathogens and Immunity
Pathogens and Immunity, 6(1), 116-134. Case Western Reserve University
bioRxiv
article-version (status) pre
article-version (number) 1

Vaccines are critical for curtailing the COVID-19 pandemic (1, 2). In the USA, two highly protective mRNA vaccines are available: BNT162b2 from Pfizer/BioNTech and mRNA-1273 from Moderna (3, 4). These vaccines induce antibodies to the SARS-CoV-2 S-pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b5576b00b0835c873ada3663ea31e16
https://pubmed.ncbi.nlm.nih.gov/34136730

Lack of Protein 4.1G Causes Altered Expression and Localization of the Cell Adhesion Molecule Nectin-Like 4 in Testis and Can Cause Male Infertility

Autor: Narla Mohandas, Lixiang Chen, John G. Conboy, Luanne L. Peters, Haibo Weng, Shaomin Yang, Amy J. Lambert, Xiuli An, Gargi Debnath, Xinhua Guo, Marilyn Parra, Anthony J. Baines

Publikováno v: Molecular and Cellular Biology. 31:2276-2286

Protein 4.1G is a member of the protein 4.1 family, which in general serves as adaptors linking transmembrane proteins to the cytoskeleton. 4.1G is thought to be widely expressed in many cells and tissues, but its function remains largely unknown. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5791063c10410fad1ba82f551e3bdb
https://doi.org/10.1128/mcb.01105-10

Protein 4.1R links E-cadherin/β-catenin complex to the cytoskeleton through its direct interaction with β-catenin and modulates adherens junction integrity

Autor: Narla Mohandas, Shaomin Yang, Xinhua Guo, Xiuli An, Gargi Debnath

Publikováno v: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1788(7):1458-1465

Protein 4.1R (4.1R) is the prototypical member of the protein 4.1 superfamily comprising of the protein 4.1 family (4.1R, 4.1B, 4.1G and 4.1N) and ERM family (ezrin, radixin and meosin). These proteins in general serve as adaptors between the membran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711bb339cd9925c1b0fd39907803de93

Impaired intestinal calcium absorption in protein 4.1R-deficient mice due to altered expression of plasma membrane calcium ATPase 1b (PMCA1b)

Autor: Hua Wang, Congrong Liu, Shaomin Yang, Haibao Weng, Lixiang Chen, Xiuli An, Gargi Debnath, Liancheng Wu, Xinhua Guo, Narla Mohandas

Publikováno v: The Journal of biological chemistry. 288(16)

Protein 4.1R was first identified in the erythrocyte membrane skeleton. It is now known that the protein is expressed in a variety of epithelial cell lines and in the epithelia of many tissues, including the small intestine. However, the physiologica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d9808122c9fabcacea1d83a11f5162e
https://pubmed.ncbi.nlm.nih.gov/23460639