Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Gareth W. John"'
Donitriptan, a Unique High-Efficacy 5-HT1B/1D Agonist: Key Features and Acute Antimigraine Potential
Autor:
Francis Colpaert, Gareth W. John, Bruno Le Grand, Yvan Verscheure, Michel Perez, Petrus J. Pauwels
Publikováno v:
CNS Drug Reviews. 6:278-289
We hypothesized that the limited acute therapeutic effectiveness of tryptamine derivatives in alleviating migraine headache could be explained by the relatively low intrinsic activity of these agents at 5-HT1B/1D receptors. Donitriptan is a novel ary
Autor:
Anne-Dominique Degryse, Delphine Denais, Bruno Le Grand, Robert Létienne, Gareth W. John, Lydia Bel, A. M. Bessac
Publikováno v:
Fundamental and Clinical Pharmacology. 20:105-113
The cardioprotective effects of cariporide were investigated against myoglobin and troponin I elevation in a model of myocardial infarction in pig, and the possible relationship between these markers and myocardial infarct size. The left circumflex c
Autor:
Ravi Shrivastava, Gareth W. John
Publikováno v:
Clinical Drug Investigation. 26:567-573
Background and objective: Recurrent aphthous ulceration is the most common oral mucosal disease known. It presents as three types: minor (most prevalent), major and herpetiform. However, there are no well established effective and reliable treatments
Publikováno v:
Nutritional Neuroscience. 8:317-321
The beneficial effects of Omega n - 3 polyunsaturated fatty acids ( n - 3 PUFA) in situations of cognitive impairment may be associated with enhanced neuronal growth. Since neuronal growth is impaired in n - 3 PUFA deficiency, and enhanced by certain
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 315:849-857
The aim of the present study was to determine whether donitriptan and sumatriptan decreased jugular venous oxygen saturation and increased carbon dioxide partial pressure in venous blood. However, previous studies conducted with these compounds canno
Autor:
Michel Perez, Yvan Verscheure, Robert Létienne, Francis Colpaert, Bruno Le Grand, Gareth W. John
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 305:749-754
The effects of donitriptan on systemic arterial-jugular venous oxygen saturation difference were evaluated in pentobarbitone-anesthetized pigs. Oxygen and carbon dioxide partial pressures in systemic arterial and jugular venous blood as well as hemog
Publikováno v:
Circulation. 106:2098-2103
Background— Thrombin plays a role in mediating ischemic injury and cardiac arrhythmias, but the mechanisms involved are poorly understood. Because voltage-gated sodium channels (VGSCs) have not previously been considered, putative effects of thromb
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 363:464-471
The clinical anti-anginal effectiveness of ranolazine is currently being evaluated. However, the mechanism of its anti-ischaemic action is still unclear. The aim of this work was to establish whether ranolazine exerts functional β-adrenoceptor antag
Publikováno v:
Cardiovascular Drug Reviews. 16:264-287
Publikováno v:
British Journal of Pharmacology. 123:205-214
1 The receptors involved in mediating the haemodynamic effects of three 5-HT1B/D receptor agonists were investigated in pentobarbitone anaesthetized rats (n = 6-17 per group). 2 Cumulative intravenous (i.v.) infusions of rizatriptan and sumatriptan (