Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Gareth S. D. Purvis"'
Publikováno v:
Cells, Vol 13, Iss 11, p 916 (2024)
Acute inflammation is a rapid and dynamic process involving the recruitment and activation of multiple cell types in a coordinated and precise manner. Here, we investigate the origin and transcriptional reprogramming of monocytes using a model of acu
Externí odkaz:
https://doaj.org/article/e62c6d9c98204d12b01a2a8f4ddda00c
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Current genetic tools designed to target macrophages in vivo often target cells from all myeloid lineages. Therefore, we sought to generate a novel transgenic mouse which has a tamoxifen inducible Cre-recombinase under the control of the human CD68 p
Externí odkaz:
https://doaj.org/article/dd662b0923cb409f976ef20ba425de8f
Autor:
Shireen Mohammad, Sura Al Zoubi, Debora Collotta, Nadine Krieg, Bianka Wissuwa, Gustavo Ferreira Alves, Gareth S. D. Purvis, Giuseppe Danilo Norata, Andrea Baragetti, Alberico Luigi Catapano, Egle Solito, Elisabeth Zechendorf, Tobias Schürholz, Wilmar Correa-Vargas, Klaus Brandenburg, Sina M. Coldewey, Massimo Collino, Muhammad M. Yaqoob, Lukas Martin, Christoph Thiemermann
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Metabolic endotoxemia has been suggested to play a role in the pathophysiology of metaflammation, insulin-resistance and ultimately type-2 diabetes mellitus (T2DM). The role of endogenous antimicrobial peptides (AMPs), such as the cathelicidin LL-37,
Externí odkaz:
https://doaj.org/article/2157c8300608458ca1bb4ae7bd4a0d60
Autor:
Caroline E. O'Riordan, Gareth S. D. Purvis, Debora Collotta, Nadine Krieg, Bianka Wissuwa, Madeeha H. Sheikh, Gustavo Ferreira Alves, Shireen Mohammad, Lauren A. Callender, Sina M. Coldewey, Massimo Collino, David R. Greaves, Christoph Thiemermann
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
We previously reported the Bruton's tyrosine kinase (BTK) inhibitors ibrutinib and acalabrutinib improve outcomes in a mouse model of polymicrobial sepsis. Now we show that genetic deficiency of the BTK gene alone in Xid mice confers protection again
Externí odkaz:
https://doaj.org/article/931268b411324e2c8343ed117a290152
Autor:
Jianmin Chen, Gareth S. D. Purvis, Debora Collotta, Sura Al Zoubi, Michelle A. Sugimoto, Antonino Cacace, Lukas Martin, Roman A. Colas, Massimo Collino, Jesmond Dalli, Christoph Thiemermann
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The development of cardiac dysfunction caused by microbial infection predicts high mortality in sepsis patients. Specialized pro-resolving mediators (SPMs) mediate resolution of inflammation in many inflammatory diseases, and are differentially expre
Externí odkaz:
https://doaj.org/article/c7482dcbf24248e5a3d10685dc45970b
Autor:
Caroline E. O'Riordan, Gareth S. D. Purvis, Debora Collotta, Fausto Chiazza, Bianka Wissuwa, Sura Al Zoubi, Lara Stiehler, Lukas Martin, Sina M. Coldewey, Massimo Collino, Christoph Thiemermann
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Sepsis is one of the most prevalent diseases in the world. The development of cardiac dysfunction in sepsis results in an increase of mortality. It is known that Bruton's tyrosine kinase (BTK) plays a role in toll-like receptor signaling and NLRP3 in
Externí odkaz:
https://doaj.org/article/b4514d0544f74995b73a8a2cbd6416c4
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Annexin-A1 (ANXA1) was first discovered in the early 1980's as a protein, which mediates (some of the) anti-inflammatory effects of glucocorticoids. Subsequently, the role of ANXA1 in inflammation has been extensively studied. The biology of ANXA1 is
Externí odkaz:
https://doaj.org/article/0aa8338713444ddf92b98e665f1e5c69
Autor:
Gareth S. D. Purvis, Massimo Collino, Rodrigo A. Loiola, Andrea Baragetti, Fausto Chiazza, Martina Brovelli, Madeeha H. Sheikh, Debora Collotta, Alessia Cento, Raffaella Mastrocola, Manuela Aragno, Juan C. Cutrin, Chris Reutelingsperger, Liliana Grigore, Alberico L. Catapano, Magdi M. Yaqoob, Giuseppe Danilo Norata, Egle Solito, Christoph Thiemermann
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Annexin A1 (ANXA1) is an endogenously produced anti-inflammatory protein, which plays an important role in the pathophysiology of diseases associated with chronic inflammation. We demonstrate that patients with type-2 diabetes have increased plasma l
Externí odkaz:
https://doaj.org/article/8d8511484b7344898fd430c8a2912807
Autor:
Carlota Recio, Daniel Lucy, Gareth S. D. Purvis, Poppy Iveson, Lynda Zeboudj, Asif J. Iqbal, Daniel Lin, Chris O’Callaghan, Lucy Davison, Esther Griesbach, Angela J. Russell, Graham M. Wynne, Lea Dib, Claudia Monaco, David R. Greaves
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
GPR84 is a member of the metabolic G protein-coupled receptor family, and its expression has been described predominantly in immune cells. GPR84 activation is involved in the inflammatory response, but the mechanisms by which it modulates inflammatio
Externí odkaz:
https://doaj.org/article/875d4c14d3c04be38fa8ea6a5323b026
Autor:
Florence L. Johnson, Nimesh S. A. Patel, Gareth S. D. Purvis, Fausto Chiazza, Jianmin Chen, Regina Sordi, Guillaume Hache, Viktoria V. Merezhko, Massimo Collino, Muhammed M. Yaqoob, Christoph Thiemermann
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 7 (2017)
BackgroundAcute kidney injury (AKI) is a major risk factor for the development of chronic kidney disease. Nuclear factor‐κB is a nuclear transcription factor activated post‐ischemia, responsible for the transcription of proinflammatory proteins.
Externí odkaz:
https://doaj.org/article/c7a32313b4ea4cdfada5330912344727