Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Gareth R. Hardisty"'
Publikováno v:
Gastro Hep Advances, Vol 2, Iss 6, Pp 788-798 (2023)
Background and Aims: Inflammatory bowel disease (IBD) is associated with increased circulating damage-associated molecular patterns, in particular, the highly pro-inflammatory mitochondrial DNA (mtDNA). Here, we study the importance of blood neutroph
Externí odkaz:
https://doaj.org/article/54c3abbc21154a52a47b0378933a9b8c
Autor:
Gareth R. Hardisty, Johanna A. Knipper, Alison Fulton, John Hopkins, Bernadette M. Dutia, Matthew D. Taylor
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Filarial helminths infect approximately 120 million people worldwide initiating a type 2 immune response in the host. Influenza A viruses stimulate a virulent type 1 pro-inflammatory immune response that in some individuals can cause uncontrolled imm
Externí odkaz:
https://doaj.org/article/de05b152f8a64d8793452d552966a2ec
Autor:
Gareth R. Hardisty, Frances Llanwarne, Danielle Minns, Jonathan L. Gillan, Donald J. Davidson, Emily Gwyer Findlay, Robert D. Gray
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Low density neutrophils (LDNs) are described in a number of inflammatory conditions, cancers and infections and associated with immunopathology, and a mechanistic role in disease. The role of LDNs at homeostasis in healthy individuals has not been in
Externí odkaz:
https://doaj.org/article/ef201149d27142c98fc2a4833c490b41
Autor:
William H. Skinner, Nicola Robinson, Gareth R. Hardisty, Holly Fleming, Ailsa Geddis, Mark Bradley, Robert D. Gray, Colin J. Campbell
Publikováno v:
Skinner, W H, Robinson, N, Hardisty, G R, Fleming, H, Geddis, A, Bradley, M, Gray, R D & Campbell, C J 2023, ' SERS microsensors for pH measurements in the lumen and ECM of stem cell derived human airway organoids ', Chemical Communications . https://doi.org/10.1039/D2CC06582G
Patient derived organoids have the potential to improve the physiological relevance of in vitro disease models. However, the 3D architecture of these self-assembled cellular structures makes probing their biochemistry more complex than in traditional
Autor:
Jonathan L. Gillan, Mithil Chokshi, Gareth R. Hardisty, Sara Clohisey Hendry, Daniel Prasca-Chamorro, Nicola J. Robinson, Benjamin Lasota, Richard Clark, Lee Murphy, Moira K. B. Whyte, J. Kenneth Baillie, Donald J. Davidson, Gang Bao, Robert D. Gray
Publikováno v:
Gillan, J L, Chokshi, M, Hardisty, G R, Clohisey Hendry, S, Prasca-Chamorro, D, Robinson, N J, Lasota, B, Clark, R, Murphy, L, Whyte, M K B, Baillie, J K, Davidson, D J, Bao, G & Gray, R D 2023, ' CAGE sequencing reveals CFTR-dependent dysregulation of type I IFN signaling in activated cystic fibrosis macrophages ', Science Advances, vol. 9, no. 21, eadg5128, pp. 1-17 . https://doi.org/10.1126/sciadv.adg5128
An intense, nonresolving airway inflammatory response leads to destructive lung disease in cystic fibrosis (CF). Dysregulation of macrophage immune function may be a key facet governing the progression of CF lung disease, but the underlying mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1d6f49036f9327fdf6f94531d99523
https://www.pure.ed.ac.uk/ws/files/350052675/sciadv.adg5128.pdf
https://www.pure.ed.ac.uk/ws/files/350052675/sciadv.adg5128.pdf
Autor:
Matthew L, Turnbull, Helen M, Wise, Marlynne Q, Nicol, Nikki, Smith, Rebecca L, Dunfee, Philippa M, Beard, Brett W, Jagger, Yvonne, Ligertwood, Gareth R, Hardisty, Haixia, Xiao, Donald J, Benton, Alice M, Coburn, Joao A, Paulo, Steven P, Gygi, John W, McCauley, Jeffery K, Taubenberger, Samantha J, Lycett, Michael P, Weekes, Bernadette M, Dutia, Paul, Digard
Publikováno v:
Journal of Virology
Two alleles of segment 8 (NS) circulate in nonchiropteran influenza A viruses. The A allele is found in avian and mammalian viruses, but the B allele is viewed as being almost exclusively found in avian viruses. This might reflect the fact that one o