Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Gareth R John"'
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170477 (2017)
Proper regulation of the coordinated transcriptional program that drives oligodendrocyte (OL) differentiation is essential for central nervous system myelin formation and repair. Nuclear import, mediated in part by a group of karyopherin alpha (Kpna)
Externí odkaz:
https://doaj.org/article/a751b4fa70f34b4c93fd2a42d9e500cf
Autor:
Benjamin M Laitman, Linnéa Asp, John N Mariani, Jingya Zhang, Jia Liu, Setsu Sawai, Candice Chapouly, Sam Horng, Elisabeth G Kramer, Nesanet Mitiku, Hannah Loo, Natalie Burlant, Xiomara Pedre, Yuko Hara, German Nudelman, Elena Zaslavsky, Young-Min Lee, David A Braun, Q Richard Lu, Goutham Narla, Cedric S Raine, Scott L Friedman, Patrizia Casaccia, Gareth R John
Publikováno v:
PLoS Biology, Vol 14, Iss 5, p e1002467 (2016)
Growth factors of the gp130 family promote oligodendrocyte differentiation, and viability, and myelination, but their mechanisms of action are incompletely understood. Here, we show that these effects are coordinated, in part, by the transcriptional
Externí odkaz:
https://doaj.org/article/2dfa39249e6546189fb8f3c3d17cf445
Autor:
Benjamin M Laitman, Gareth R John
Publikováno v:
PLoS Biology, Vol 13, Iss 11, p e1002300 (2015)
Alterations in the structure and organization of the aging central nervous system (CNS), and associated functional deficits, result in cognitive decline and increase susceptibility to neurodegeneration. Age-related changes to the neurovascular unit (
Externí odkaz:
https://doaj.org/article/e8c8442b4604426486c884940e091109
Autor:
Nesanet Mitiku, Jingya Zhang, Sean Mahase, Jimmy L. Huynh, John N. Mariani, Erwin P. Bottinger, Benjamin M. Laitman, Azeb Tadesse Argaw, Patrizia Casaccia, Dipankar Dutta, Linnea Asp, Andleeb Zameer, Fernand Hayot, Carmen V. Melendez-Vasquez, Mateusz Urbanski, Gareth R. John, Chester W. Brown
Publikováno v:
Development. 145
Development was made aware by a reader of potential duplication of data in [Fig. 3][1] and [Fig. S3][2] of Development (2014) 141, [2414-2428][3] ([doi:10.1242/dev.106492][4]). The journal contacted the authors who said that some of the bands in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c10e7aaf89cfa89ac381b4246077455
https://doi.org/10.1242/dev.168708
https://doi.org/10.1242/dev.168708
Autor:
Edward D. Crandall, Michael V. Sofroniew, Yuko Hara, John N. Mariani, Anthony Therattil, Sam Horng, Candice Chapouly, Azeb Tadesse Argaw, Sarah Moyon, Alexandra Gordon, Karla Kim, Per Flodby, Setsu Sawai, Zea Borok, Gareth R. John
Publikováno v:
Journal of Clinical Investigation
Journal of Clinical Investigation, 2017, 127 (8), pp.3136-3151. ⟨10.1172/JCI91301⟩
The Journal of clinical investigation, vol 127, iss 8
Journal of Clinical Investigation, 2017, 127 (8), pp.3136-3151. ⟨10.1172/JCI91301⟩
The Journal of clinical investigation, vol 127, iss 8
Lesions and neurologic disability in inflammatory CNS diseases such as multiple sclerosis (MS) result from the translocation of leukocytes and humoral factors from the vasculature, first across the endothelial blood-brain barrier (BBB) and then acros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f109541dc5d12f7fc1d671bf21f26b27
https://amu.hal.science/hal-04146376
https://amu.hal.science/hal-04146376
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170477 (2017)
PLoS ONE
PLoS ONE
Proper regulation of the coordinated transcriptional program that drives oligodendrocyte (OL) differentiation is essential for central nervous system myelin formation and repair. Nuclear import, mediated in part by a group of karyopherin alpha (Kpna)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd973bb3b3a56dd2a87eba1e725b373
http://europepmc.org/articles/PMC5249183?pdf=render
http://europepmc.org/articles/PMC5249183?pdf=render
Autor:
Tomasz Rusielewicz, Cedric S. Raine, Evangelos Damanakis, Jennifer Nam, Gareth R. John, Carmen V. Melendez-Vasquez
Publikováno v:
Glia
The oligodendrocyte (OL), the myelinating cell of the central nervous system, undergoes dramatic changes in the organization of its cytoskeleton as it differentiates from a precursor (oligodendrocyte precursor cells) to a myelin-forming cell. These c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2166cf2a8f85df74e386b6f980d6e0b0
https://doi.org/10.1002/glia.22627
https://doi.org/10.1002/glia.22627
Autor:
Catherine Lubetzki, Michael Wegner, Dipankar Dutta, Gareth R. John, Jimmy L. Huynh, Ben Emery, Dan Ma, Jun Zhu, Fan Zhang, Rebecca Lawrence, Patrizia Casaccia, Sarah Moyon, Guoping Fan, Seungyeul Yoo, Jeffrey L. Dupree, Robin J.M. Franklin
Publikováno v:
Moyon, S; Huynh, JL; Dutta, D; Zhang, F; Ma, D; Yoo, S; et al.(2016). Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage. CELL REPORTS, 15(4), 748-760. doi: 10.1016/j.celrep.2016.03.060. UCLA: Retrieved from: http://www.escholarship.org/uc/item/5pw591n7
Cell Reports, Vol 15, Iss 4, Pp 748-760 (2016)
Cell Reports
Cell Reports, Elsevier Inc, 2016, 15, pp.1-13. ⟨10.1016/j.celrep.2016.03.060⟩
Cell reports, vol 15, iss 4
Cell Reports, 2016, 15, pp.1-13. ⟨10.1016/j.celrep.2016.03.060⟩
Cell Reports, Vol 15, Iss 4, Pp 748-760 (2016)
Cell Reports
Cell Reports, Elsevier Inc, 2016, 15, pp.1-13. ⟨10.1016/j.celrep.2016.03.060⟩
Cell reports, vol 15, iss 4
Cell Reports, 2016, 15, pp.1-13. ⟨10.1016/j.celrep.2016.03.060⟩
International audience; Oligodendrocytes derive from progenitors (OPCs) through the interplay of epigenomic and transcriptional events. By integrating high-resolution methylomics, RNA-sequencing, and multiple transgenic lines, this study defines the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0359b9cbfc43f26c5f7bd8c8139e3d09
https://publications.aston.ac.uk/id/eprint/32480/1/Functional_Characterization_of_DNA_Methylation_in.pdf
https://publications.aston.ac.uk/id/eprint/32480/1/Functional_Characterization_of_DNA_Methylation_in.pdf
Autor:
Linnea Asp, Dipankar Dutta, John N. Mariani, Jeremy Seto, Sean Mahase, Michael V. Sofroniew, Kristina Navrazhina, Trinh Pham, Napoleone Ferrara, Jingya Zhang, Azeb Tadesse Argaw, Gareth R. John, Elisabeth G. Kramer
Publikováno v:
Journal of Clinical Investigation. 122:2454-2468
In inflammatory CNS conditions such as multiple sclerosis (MS), current options to treat clinical relapse are limited, and more selective agents are needed. Disruption of the blood-brain barrier (BBB) is an early feature of lesion formation that corr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd6eef7264b81b7c593d8da3f93422d
https://doi.org/10.1172/jci60842
https://doi.org/10.1172/jci60842
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 70:1138-1150
Central nervous system hypomyelination is a feature common to a number of transgenic (Tg) mouse lines that express a variety of unrelated exogenous (i.e. non-central nervous system) transgenes. In this report, we document hypomyelination structurally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4c9b2bd7eb6c2fef0f2f8ec294d3f6
https://doi.org/10.1097/nen.0b013e31823b188b
https://doi.org/10.1097/nen.0b013e31823b188b