Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Gareth Maher‐Edwards"'
Autor:
Lina Keutzer, Huifang You, Ali Farnoud, Joakim Nyberg, Sebastian G. Wicha, Gareth Maher-Edwards, Georgios Vlasakakis, Gita Khalili Moghaddam, Elin M. Svensson, Michael P. Menden, Ulrika S. H. Simonsson, on behalf of the UNITE4TB Consortium
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1530 (2022)
Pharmacometrics (PM) and machine learning (ML) are both valuable for drug development to characterize pharmacokinetics (PK) and pharmacodynamics (PD). Pharmacokinetic/pharmacodynamic (PKPD) analysis using PM provides mechanistic insight into biologic
Externí odkaz:
https://doaj.org/article/25a790d93aeb473e9a0152c76324f8f0
Autor:
Eric L. Nuermberger, Maria Santos Martínez-Martínez, Olalla Sanz, Beatriz Urones, Jorge Esquivias, Heena Soni, Rokeya Tasneen, Sandeep Tyagi, Si-Yang Li, Paul J. Converse, Helena I. Boshoff, Gregory T. Robertson, Gurdyal S. Besra, Katherine A. Abrahams, Anna M. Upton, Khisimuzi Mdluli, Gary W. Boyle, Sam Turner, Nader Fotouhi, Nicholas C. Cammack, Juan Miguel Siles, Marta Alonso, Jaime Escribano, Joel Lelievre, Joaquin Rullas-Trincado, Esther Pérez-Herrán, Robert H. Bates, Gareth Maher-Edwards, David Barros, Lluís Ballell, Elena Jiménez
Publikováno v:
Antimicrobial Agents and Chemotherapy. 66
As a result of a high-throughput compound screening campaign using Mycobacterium tuberculosis -infected macrophages, a new drug candidate for the treatment of tuberculosis has been identified. GSK2556286 inhibits growth within human macrophages (50%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a0efb69d85ba133e740da0ce522724b
https://doi.org/10.1128/aac.00132-22
https://doi.org/10.1128/aac.00132-22
Publikováno v:
Alzheimer's & Dementia : Translational Research & Clinical Interventions
Background The lipoprotein-associated phospholipase A 2 inhibitor (Lp-PLA 2 ), rilapladib (SB659032), is being evaluated as a potential treatment to slow the progression of Alzheimer's disease (AD). Methods One hundred twenty-four subjects with possi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d39f9f8900a00f0a541ebd90218675
Autor:
Carly Barnett, Alexander Kurz, Gareth Maher-Edwards, Diane Boswell, Michael Gold, Beth Safirstein, Juan Paul Schronen, Carolyn Watson, John A. Ascher, Manuel Fernandez, John T. Davies, Orazio Zanetti, Marina Zvartau-Hind
Publikováno v:
Alzheimer's & Dementia : Translational Research & Clinical Interventions
Background Two previous studies of SB742457, a 5-hydroxytryptamine (5-HT 6 ) receptor antagonist, suggested the efficacy of improvements in cognition and global outcome in Alzheimer's disease (AD). Methods Two randomized, placebo-controlled trials in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20efebd3530e4592d4f181315eff4299
https://doi.org/10.1016/j.trci.2015.04.001
https://doi.org/10.1016/j.trci.2015.04.001
Autor:
Gareth Maher-Edwards, Gemma Jacobs, Jo Hunter, Michael Gold, Pauline Williams, Jackie Hunter, Ruth Dixon, Gillian Hopton
Publikováno v:
International Journal of Geriatric Psychiatry. 26:536-544
Objective To estimate the treatment effects of SB-742457 and donepezil in Alzheimer disease (AD) in a contemporary clinical trial. Method Randomized, controlled, parallel-group, exploratory study with a 4-week, single-blind, placebo run-in phase and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c27ad945a72b91f1b2667d29f896230
https://doi.org/10.1002/gps.2562
https://doi.org/10.1002/gps.2562
Autor:
M. Zvartau-Hind, A.J. Hunter, M. Gold, P. Williams, Gareth Maher-Edwards, G. Hopton, G. Jacobs, M. Davy
Publikováno v:
Current Alzheimer Research. 7:374-385
Background: This randomized, double-blind, placebo-controlled study investigated the efficacy and tolerability of the 5-HT6 receptor antagonist, SB-742457, in subjects with mild-to-moderate probable Alzheimers disease (AD). Methods: Participating sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe0dbfe330c8dee57b95630e2541195
https://doi.org/10.2174/156720510791383831
https://doi.org/10.2174/156720510791383831
Autor:
Robert Lai, Chanchal Bains, Steven J. Barrett, Gareth Maher-Edwards, John G. Weil, Janette P. Laroche, David J. Webb, David A. Hosford, Michael C. Irizarry
Publikováno v:
Journal of Alzheimer's Disease. 14:301-311
One limitation of several recent 24 week Alzheimer's disease (AD) clinical trials was the lack of cognitive decline detected by the AD Assessment Scale-cognitive subscale (ADAS-cog) in the placebo groups, possibly obscuring true medication effects. D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5313ccc230412cfd337e770014f84a
https://doi.org/10.3233/jad-2008-14304
https://doi.org/10.3233/jad-2008-14304
Publikováno v:
Alzheimer's & Dementia. 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a67978ac1517574246e8de34de3ed623
https://doi.org/10.1016/j.jalz.2014.04.506
https://doi.org/10.1016/j.jalz.2014.04.506
Autor:
Gareth Maher‐Edwards, Marina Zvartau‐Hind, John Davies, Kurz Alexander, Juan Schronen, Diane Boswell, John Ascher, Michael Gold
Publikováno v:
Alzheimer's & Dementia. 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7eb25789391eaa4fd44791982df9584f
https://doi.org/10.1016/j.jalz.2011.05.2236
https://doi.org/10.1016/j.jalz.2011.05.2236
Autor:
Gareth Maher-Edwards, Carly Donovan, Marina Zvartau-Hind, John A. Ascher, Carolyn Watson, Orazio Zanetti, Manuel Fernández, Beth Safirstein, Michael Gold, John T. Davies
Publikováno v:
Alzheimer's & Dementia. 7
that critically regulate As transport at the BBB and that may be influenced by vascular challenges.Methods: Transverse aortic coarctation (TAC) was performed inmice to induce chronic hypertension. RAGE activationwas analyzed at different time points
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d14d87a903bb1c81517a7f01951c400a
https://doi.org/10.1016/j.jalz.2011.09.022
https://doi.org/10.1016/j.jalz.2011.09.022