Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Gareth M. Thomas"'
Autor:
Nicolas H. Piguel, Shaun S. Sanders, Francesca I. De Simone, Maria D. Martin-de-Saavedra, Emmarose McCoig, Leonardo E. Dionisio, Katharine R. Smith, Gareth M. Thomas, Peter Penzes
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionAnkG, encoded by the ANK3 gene, is a multifunctional scaffold protein with complex isoform expression: the 480 and 270 kDa isoforms have roles at the axon initial segment and node of Ranvier, whereas the 190 kDa isoform (AnkG-190) has an
Externí odkaz:
https://doaj.org/article/52a343df27d8423883a4ff7c95f0ced1
Autor:
Feng Li, Tsz Y. Lo, Leann Miles, Qin Wang, Harun N. Noristani, Dan Li, Jingwen Niu, Shannon Trombley, Jessica I. Goldshteyn, Chuxi Wang, Shuchao Wang, Jingyun Qiu, Katarzyna Pogoda, Kalpana Mandal, Megan Brewster, Panteleimon Rompolas, Ye He, Paul A. Janmey, Gareth M. Thomas, Shuxin Li, Yuanquan Song
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
The Atr-Check1 pathway is involved in cell cycle and the DNA damage response. Here, the authors show that the Atr-Check1 pathway can inhibit axon regeneration in response to Piezo-mediated mechanosensation, affecting functional recovery.
Externí odkaz:
https://doaj.org/article/005c24fb0ae4423db9855a4fda43b7ac
Autor:
Rebeca Mejias, Juan J. Rodriguez-Gotor, Minae Niwa, Irina N. Krasnova, Abby Adamczyk, Mei Han, Gareth M. Thomas, Zheng-Xiong Xi, Richard L. Huganir, Mikhail V. Pletnikov, Akira Sawa, Jean-Lud Cadet, Tao Wang
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Novelty-seeking behaviors and impulsivity are personality traits associated with several psychiatric illnesses including attention deficits hyperactivity disorders. The underlying neural mechanisms remain poorly understood. We produced and c
Externí odkaz:
https://doaj.org/article/dabac57c5e004138824d4951af477f0a
Publikováno v:
People, Place and Policy Online, Vol 14, Iss 2, Pp 157-172 (2020)
Externí odkaz:
https://doaj.org/article/baf58d16e27b4891a87738239475b125
Autor:
Jingwen Niu, Shaun S. Sanders, Hey-Kyeong Jeong, Sabrina M. Holland, Yue Sun, Kaitlin M. Collura, Luiselys M. Hernandez, Haoliang Huang, Michael R. Hayden, George M. Smith, Yang Hu, Yishi Jin, Gareth M. Thomas
Publikováno v:
Cell Reports, Vol 33, Iss 7, Pp 108365- (2020)
Summary: After optic nerve crush (ONC), the cell bodies and distal axons of most retinal ganglion cells (RGCs) degenerate. RGC somal and distal axon degenerations were previously thought to be controlled by two parallel pathways, involving activation
Externí odkaz:
https://doaj.org/article/465db966de9646949ceb4c790e1a07a5
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
The mechanistic target of rapamycin (mTOR) Complex 1 (mTORC1) controls growth and proliferation of non-neuronal cells, while during neuronal development mTORC1 responds to glutamate and neurotrophins to promote neuronal migration and dendritic arbori
Externí odkaz:
https://doaj.org/article/c1d7c744e91149d6beac6b8bd178ce79
Autor:
Shaun S Sanders, Luiselys M Hernandez, Heun Soh, Santi Karnam, Randall S Walikonis, Anastasios V Tzingounis, Gareth M Thomas
Publikováno v:
eLife, Vol 9 (2020)
The palmitoyl acyltransferase (PAT) ZDHHC14 is highly expressed in the hippocampus and is the only PAT predicted to bind Type-I PDZ domain-containing proteins. However, ZDHHC14’s neuronal roles are unknown. Here, we identify the PDZ domain-containi
Externí odkaz:
https://doaj.org/article/3bf2d48f0eda4e9999d27548f27e9678
Autor:
Seung C. Ahn, Gareth M. Thomas
Publikováno v:
Empirical Economics.
Autor:
Audrey Montersino, Kaitlin M. Collura, Shaun S. Sanders, Sabrina M. Holland, Jingwen Niu, Gareth M. Thomas
Publikováno v:
J Biol Chem
Palmitoylation, the modification of proteins with the lipid palmitate, is a key regulator of protein targeting and trafficking. However, knowledge of the roles of specific palmitoyl acyltransferases (PATs), which catalyze palmitoylation, is incomplet
Palmitoylation couples the kinases DLK and JNK3 to facilitate prodegenerative axon-to-soma signaling
Autor:
Jingwen Niu, Sabrina M. Holland, Andrea Ketschek, Kaitlin M. Collura, Natasha L. Hesketh, Takashi Hayashi, Gianluca Gallo, Gareth M. Thomas
Publikováno v:
Science signaling. 15(727)
Dual leucine-zipper kinase (DLK; a MAP3K) mediates neuronal responses to diverse injuries and insults through the c-Jun N-terminal kinase (JNK) family of mitogen-activated protein kinases (MAPKs). Here, we identified two ways through which DLK is cou