Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Gareth L, Ackland"'
Autor:
Aaron James, David Bruce, Nicholas Tetlow, Amour B.U. Patel, Ethel Black, Nicole Whitehead, Anna Ratcliff, Alice Jamie Humphreys, Neil MacDonald, Gayle McDonnell, Ravishankar Raobaikady, Jeeveththaa Thirugnanasambanthar, Jeuela I. Ravindran, Gary Minto, Tom E.F. Abbott, Shaman Jhanji, Don Milliken, Gareth L. Ackland
Publikováno v:
BJA Open, Vol 8, Iss , Pp 100238- (2023)
Background: Impaired vagal function in older individuals, quantified by the ‘gold standard’ delayed heart rate recovery after maximal exercise (HRRexercise), is an independent predictor of cardiorespiratory capacity and mortality (particularly wh
Externí odkaz:
https://doaj.org/article/a0cdd07f6b0f40118d88c1fea47dbc50
Autor:
Olga Kopach, Sergyi Sylantyev, Lucie Bard, Piotr Michaluk, Janosch P. Heller, Ana Gutierrez del Arroyo, Gareth L. Ackland, Alexander V. Gourine, Dmitri A. Rusakov
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107236- (2023)
Summary: Neutrophils are white blood cells that are critical to acute inflammatory and adaptive immune responses. Their swarming-pattern behavior is controlled by multiple cellular cascades involving calcium-dependent release of various signaling mol
Externí odkaz:
https://doaj.org/article/e29399bbfa284d4aac50d5a7106fd7e9
Autor:
Sophie L. M. Walker, Chand Muthoo, Jenifer Sanchez, Ana Gutierrez Del Arroyo, Gareth L. Ackland
Publikováno v:
Intensive Care Medicine Experimental, Vol 10, Iss 1, Pp 1-20 (2022)
Take-home message Sex differences in sepsis are underexplored, even though female sex appears to be cardioprotective in early sepsis. In early normovolaemic polymicrobial sepsis, hyperdynamic response occurs in males, whereas myocardial stress/injury
Externí odkaz:
https://doaj.org/article/63be37f961f54a658011efacee195293
Autor:
Valerie Lan-Pak-Kee, Gareth L. Ackland, Timothy C. Egan, Tom EF. Abbott, Fatima Elsheikh, Stephen Barrett, Mevan Gooneratne, Shaun Montagu May, Matthew Mitchard, Timothy O'Neill, Jennifer Overend, Ching-Ling Pang, Archchana Radhakrishnan, Toby Reynolds, Mehul Vadher, Parvesh Verma, Matthew Wikner, Andrew Wood
Publikováno v:
BJA Open, Vol 4, Iss , Pp 100111- (2022)
Background: Early intraoperative hypotension is associated with acute kidney and myocardial injury in patients undergoing noncardiac surgery. Precise arterial blood pressure measurement before and during the induction of general anaesthesia may avert
Externí odkaz:
https://doaj.org/article/a3658c11a988405386c6e6b4098a29e5
Publikováno v:
BJA Open, Vol 2, Iss , Pp 100017- (2022)
Background: Established or acquired loss of parasympathetic vagal tone is associated with complications, including pain, after noncardiac surgery. We describe a study protocol designed to test the hypothesis that transcutaneous auricular nerve stimul
Externí odkaz:
https://doaj.org/article/6b53139851f94dc8b9e66e4cbd6e1e01
Autor:
Lindsea C. Booth, Song T. Yao, Alla Korsak, David G.S. Farmer, Sally G. Hood, Daniel McCormick, Quinn Boesley, Angela A. Connelly, Stuart J. McDougall, Willian S. Korim, Sarah-Jane Guild, Svetlana Mastitskaya, Phuong Le, Anja G. Teschemacher, Sergey Kasparov, Gareth L. Ackland, Simon C. Malpas, Robin M. McAllen, Andrew M. Allen, Clive N. May, Alexander V. Gourine
Publikováno v:
Brain Stimulation, Vol 14, Iss 1, Pp 88-96 (2021)
Background: Electrical stimulation applied to individual organs, peripheral nerves, or specific brain regions has been used to treat a range of medical conditions. In cardiovascular disease, autonomic dysfunction contributes to the disease progressio
Externí odkaz:
https://doaj.org/article/03a4bef93ac24e2d8772b644715a7a34
Autor:
Shaun M. May, Eric Chiang, Anna Reyes, Gladys Martir, Amour Patel, Shamir Karmali, Sanjiv Patel, Simeon West, Ana Gutierrez del Arroyo, Alexander V. Gourine, Gareth L. Ackland
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 16, Iss , Pp 100299- (2021)
Experimental animal studies on the mechanisms of remote ischaemic conditioning (RIC)-induced cardioprotection against ischaemia/reperfusion injury demonstrate involvement of both neuronal and humoral pathways. Autonomic parasympathetic (vagal) pathwa
Externí odkaz:
https://doaj.org/article/75333d07cbf14780a443e165a528e261
Autor:
Ana Gutierrez del Arroyo, Anna Hadjihambi, Jenifer Sanchez, Egor Turovsky, Vitaly Kasymov, David Cain, Tom D. Nightingale, Simon Lambden, Seth G.N. Grant, Alexander V. Gourine, Gareth L. Ackland
Publikováno v:
EBioMedicine, Vol 47, Iss , Pp 457-469 (2019)
Background: Neutrophil depletion improves neurologic outcomes in experimental sepsis/brain injury. We hypothesized that neutrophils may exacerbate neuronal injury through the release of neurotoxic quantities of the neurotransmitter glutamate. Methods
Externí odkaz:
https://doaj.org/article/0aaa2e17d6344966b236b4d45e768b8f
Autor:
Adam D. Farmer, Adam Strzelczyk, Alessandra Finisguerra, Alexander V. Gourine, Alireza Gharabaghi, Alkomiet Hasan, Andreas M. Burger, Andrés M. Jaramillo, Ann Mertens, Arshad Majid, Bart Verkuil, Bashar W. Badran, Carlos Ventura-Bort, Charly Gaul, Christian Beste, Christopher M. Warren, Daniel S. Quintana, Dorothea Hämmerer, Elena Freri, Eleni Frangos, Eleonora Tobaldini, Eugenijus Kaniusas, Felix Rosenow, Fioravante Capone, Fivos Panetsos, Gareth L. Ackland, Gaurav Kaithwas, Georgia H. O'Leary, Hannah Genheimer, Heidi I. L. Jacobs, Ilse Van Diest, Jean Schoenen, Jessica Redgrave, Jiliang Fang, Jim Deuchars, Jozsef C. Széles, Julian F. Thayer, Kaushik More, Kristl Vonck, Laura Steenbergen, Lauro C. Vianna, Lisa M. McTeague, Mareike Ludwig, Maria G. Veldhuizen, Marijke De Couck, Marina Casazza, Marius Keute, Marom Bikson, Marta Andreatta, Martina D'Agostini, Mathias Weymar, Matthew Betts, Matthias Prigge, Michael Kaess, Michael Roden, Michelle Thai, Nathaniel M. Schuster, Nicola Montano, Niels Hansen, Nils B. Kroemer, Peijing Rong, Rico Fischer, Robert H. Howland, Roberta Sclocco, Roberta Sellaro, Ronald G. Garcia, Sebastian Bauer, Sofiya Gancheva, Stavros Stavrakis, Stefan Kampusch, Susan A. Deuchars, Sven Wehner, Sylvain Laborde, Taras Usichenko, Thomas Polak, Tino Zaehle, Uirassu Borges, Vanessa Teckentrup, Vera K. Jandackova, Vitaly Napadow, Julian Koenig
Publikováno v:
Frontiers in Human Neuroscience, Vol 14 (2021)
Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation (tVNS) across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular bra
Externí odkaz:
https://doaj.org/article/559b65cb001b4e368330a755e0899b33
Publikováno v:
Intensive Care Medicine Experimental, Vol 5, Iss 1, Pp 1-15 (2017)
Abstract Background Heart rate variability (HRV) has been used to assess cardiac autonomic activity in critically ill patients, driven by translational and biomarker research agendas. Several clinical and technical factors can interfere with the meas
Externí odkaz:
https://doaj.org/article/816840080e78439083e6eb104a81844d