Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Gareth John Thomas"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2759-2762
The cyclohexane analogues 3 and 4 of the piperidine carboxamide 1 have been synthesized. The trans isomer 3 is more potent than the hydroxyethylamine 1 versus HIV-1 proteinase, while the cis isomer 4 is less potent.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eaf569eb04454f3c9deac054afc03e95
https://doi.org/10.1016/s0960-894x(01)80590-4
https://doi.org/10.1016/s0960-894x(01)80590-4
Autor:
Colin C. F. Blake, Hans R. Hartmann, Michael J. Broadhurst, Elizabeth Keech, David J. Bushnell, Gareth John Thomas, Cedric H. Hassall, Nigel Adams, Alan R. Stratton
Publikováno v:
ChemInform. 22
A number of 4-demethoxyanthracyclines having hydroxylalkyl functions at the 9-position have previously been synthesized and shown to have potent antitumor activity. A series of carbamate derivatives of these (hydroxyalkyl)anthracyclines have now been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17b528e30e7498387419522dad27a9bc
https://doi.org/10.1002/chin.199108332
https://doi.org/10.1002/chin.199108332
Autor:
David J. Bushnell, Hans R. Hartmann, Elizabeth Keech, Michael J. Broadhurst, Nigel Adams, Gareth John Thomas, Colin C. F. Blake, Alan R. Stratton, Cedric H. Hassall
Publikováno v:
ChemInform. 22
A versatile and efficient synthetic route to 4-demethoxyanthracyclinones has been utilized in the preparation of a number of aglycons having 9-alkyl, 9-(hydroxylalkyl), or 9-carbamoyl substituents. Silver trifluoromethanesulfonate catalyzed coupling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d72253667830faa4509363f3eeea134e
https://doi.org/10.1002/chin.199108331
https://doi.org/10.1002/chin.199108331
Autor:
Hans R. Hartmann, Michael J. Broadhurst, Alan R. Stratton, Elizabeth Keech, David J. Bushnell, Colin C. F. Blake, Nigel Adams, Gareth John Thomas, Cedric H. Hassall
Publikováno v:
Journal of Medicinal Chemistry. 33:2375-2379
A versatile and efficient synthetic route to 4-demethoxyanthracyclinones has been utilized in the preparation of a number of aglycons having 9-alkyl, 9-(hydroxylalkyl), or 9-carbamoyl substituents. Silver trifluoromethanesulfonate catalyzed coupling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52ef961ea830ba70a46e005daa4d0f9
https://doi.org/10.1021/jm00171a010
https://doi.org/10.1021/jm00171a010
Autor:
Kevin E. B. Parkes, David J. Bushnell, Philippe Wong Kai-In, Andrew C. Freeman, Julie E Cansfield, JH Merrett, Ian R Johns, Stephen J. Dunsdon, Stewart J. Baker, Joseph Armstrong Martin, Mark Holland, Heather Simmonite, Andrea Walmsley, Robert Wilson Lambert, Gareth John Thomas, Elizabeth Keech, Richard A. Hopkins
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(13)
A series of carboxamide derivatives of 5′-amino-2′,5′-dideoxy-5-ethyluridine has been prepared as inhibitors of HSV-TK (herpes simplex virus thymidine kinase). The most potent compounds were derived from xanthene, thioxanthene and dihydroanthra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55d79c544bf1e8d1e9a72ae0699f3ca
https://pubmed.ncbi.nlm.nih.gov/11425530
https://pubmed.ncbi.nlm.nih.gov/11425530
Publisher Summary This chapter focuses on inhibitors of HIV Proteinase. X-ray crystallographic structures of HIV proteinase complexed with a diverse range of inhibitors have now been published. Despite large differences in the structures of the bound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b366557821abdeb8b11fa25a0dadd7b
https://doi.org/10.1016/s0079-6468(08)70455-7
https://doi.org/10.1016/s0079-6468(08)70455-7
Autor:
Gareth John Thomas, Alan R. Stratton, Elizabeth Keech, David J. Bushnell, Nigel Adams, Colin C. F. Blake, Hans R. Hartmann, Cedric H. Hassall, Michael J. Broadhurst
Publikováno v:
Journal of medicinal chemistry. 33(9)
A number of 4-demethoxyanthracyclines having hydroxylalkyl functions at the 9-position have previously been synthesized and shown to have potent antitumor activity. A series of carbamate derivatives of these (hydroxyalkyl)anthracyclines have now been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a568f7300a9d2917e991fa34547f2a34
https://pubmed.ncbi.nlm.nih.gov/2391682
https://pubmed.ncbi.nlm.nih.gov/2391682
Autor:
Michael John Hall, Gareth John Thomas, Edgar P. Heimer, Ian B. Duncan, Robert W. Lambert, Joseph A. Martin
Publikováno v:
Journal of Medicinal Chemistry. 32:367-374
Phosphonoacetic acid (PAA, 1) was coupled with various acyclonucleosides, 2'-deoxyuridines, cytidines, and arabinosyluracils, with 2,4,6-triisopropylbenzenesulfonyl chloride (TPS) or dicyclohexylcarbodiimide (DCCI) as condensing agents, to give a ran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d7546ea3b7380ce720776e7526eff2
https://doi.org/10.1021/jm00122a014
https://doi.org/10.1021/jm00122a014
Publikováno v:
Tetrahedron. 40:4649-4656
Optically active 4-demethoxyanthracyclinoiies (39a-g) bearing a variety of substituents at the 9position have been synthesised by an analogous route to that previously employed by us for (+)-4-demethoxydaunomycinone (5). These novel anthracyclinones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae3684d4fec36d4f43253635eae2af92
https://doi.org/10.1016/s0040-4020(01)91526-1
https://doi.org/10.1016/s0040-4020(01)91526-1
Publikováno v:
Tetrahedron Letters. 25:6059-6062
The properties of 13(S)-dihydro-4-demethoxydaunorubicin, rather than the 13(R)-isomer, correspond to those of the microbial and mammalian reduction product of 4-demethoxydauno-rubicin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bce630bd4483c606a07a98bd6c48a6f
https://doi.org/10.1016/s0040-4039(01)81761-5
https://doi.org/10.1016/s0040-4039(01)81761-5