A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins

Autor: Dinesh C. Soares, Shaun Mackie, Sheila Christie, Elizabeth A. Blackburn, Gareth James Briggs, David J. Porteous, Jennifer E. Eykelenboom, Walter J. Muir, Nicholas J. Bradshaw, Elise L.V. Malavasi, M. P. Malloy, J. Kirsty Millar, Fumiaki Ogawa, Janice Bramham, Martin A. Wear, Paraskevi Makedonopoulou, Andrew M. McIntosh, Douglas Blackwood

Publikováno v: Human Molecular Genetics
Eykelenboom, J E, Briggs, G J, Bradshaw, N J, Soares, D C, Ogawa, F, Christie, S, Malavasi, E L V, Makedonopoulou, P, Mackie, S, Malloy, M P, Wear, M A, Blackburn, E A, Bramham, J, Mcintosh, A M, Blackwood, D H, Muir, W J, Porteous, D J & Millar, J K 2012, ' A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins ', Human Molecular Genetics, vol. 21, no. 15, pp. 3374-3386 . https://doi.org/10.1093/hmg/dds169

Disrupted-In-Schizophrenia 1 (DISC1) was identified as a risk factor for psychiatric illness through its disruption by a balanced chromosomal translocation, t(1;11)(q42.1;q14.3), that co-segregates with schizophrenia, bipolar disorder and depression.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf608bb1c71feccfc1a425af7044675
https://doi.org/10.1093/hmg/dds169