Zobrazeno 1 - 10
of 360
pro vyhledávání: '"Gareth J. Thomas"'
Autor:
Philip J. Basford, Orestis L. Katsamenis, Richard P. Boardman, Stephanie K. Robinson, Peter M. Lackie, Elena Konstantinopoulou, J. Arjuna Ratnayaka, Anton Page, Gareth J. Thomas, Patricia M. Goggin, Ian Sinclair, Simon J. Cox, Philipp Schneider
Publikováno v:
Wellcome Open Research, Vol 8 (2023)
Background The University of Southampton, in collaboration with the University Hospital Southampton (UHS) NHS Foundation Trust and industrial partners, has been at the forefront of developing three-dimensional (3D) imaging workflows using X-ray micro
Externí odkaz:
https://doaj.org/article/b0eca1b24de04d559f74a9f42a48df65
Autor:
Christopher J. Hanley, Sara Waise, Matthew J. Ellis, Maria A. Lopez, Wai Y. Pun, Julian Taylor, Rachel Parker, Lucy M. Kimbley, Serena J. Chee, Emily C. Shaw, Jonathan West, Aiman Alzetani, Edwin Woo, Christian H. Ottensmeier, Matthew J. J. Rose-Zerilli, Gareth J. Thomas
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Fibroblast heterogeneity is a prominent but poorly understood feature of solid tumours. Here three major fibroblast subpopulations in non-small cell lung cancer are identified and characterised through single cell RNA-sequencing, multiplexed immunohi
Externí odkaz:
https://doaj.org/article/90c9737e349b4a0f860180335c1700ab
Autor:
Philip J. Basford, Orestis L. Katsamenis, Richard P. Boardman, Stephanie K. Robinson, Peter M. Lackie, Elena Konstantinopoulou, J. Arjuna Ratnayaka, Anton Page, Gareth J. Thomas, Patricia M. Goggin, Ian Sinclair, Simon J. Cox, Philipp Schneider
Publikováno v:
Wellcome Open Research, Vol 8 (2023)
Background: The University of Southampton, in collaboration with the University Hospital Southampton (UHS) NHS Foundation Trust and industrial partners, has been at the forefront of developing three-dimensional (3D) imaging workflows using X-ray micr
Externí odkaz:
https://doaj.org/article/19ceba3d86a1405fb292bd21883dfb12
Autor:
Ankur Chakravarthy, Ian Reddin, Stephen Henderson, Cindy Dong, Nerissa Kirkwood, Maxmilan Jeyakumar, Daniela Rothschild Rodriguez, Natalia Gonzalez Martinez, Jacqueline McDermott, Xiaoping Su, Nagayasau Egawa, Christina S. Fjeldbo, Vilde Eide Skingen, Heidi Lyng, Mari Kyllesø Halle, Camilla Krakstad, Afschin Soleiman, Susanne Sprung, Matt Lechner, Peter J. I. Ellis, Mark Wass, Martin Michaelis, Heidi Fiegl, Helga Salvesen, Gareth J. Thomas, John Doorbar, Kerry Chester, Andrew Feber, Tim R. Fenton
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Human papillomavirus (HPV) is a known cause of cervical cancer. Here, the authors perform a multi-omic analysis using published cervical squamous cell carcinoma cohorts from the USA, Europe, and SubSaharan Africa and identify two cervical squamous ce
Externí odkaz:
https://doaj.org/article/9a5c4607e718467ca9be497358a18ce0
Autor:
Simon Eschweiler, Alice Wang, Ciro Ramírez-Suástegui, Adrian von Witzleben, Yingcong Li, Serena J. Chee, Hayley Simon, Monalisa Mondal, Matthew Ellis, Gareth J. Thomas, Vivek Chandra, Christian H. Ottensmeier, Pandurangan Vijayanand
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112040- (2023)
Summary: Junctional adhesion molecule-like protein (JAML) serves as a co-stimulatory molecule in γδ T cells. While it has recently been described as a cancer immunotherapy target in mice, its potential to cause toxicity, specific mode of action wit
Externí odkaz:
https://doaj.org/article/327579dd01244769ba874a0df16d447c
Autor:
Rahul Sreekumar, Hajir Al‐Saihati, Muhammad Emaduddin, Karwan Moutasim, Massimiliano Mellone, Ashish Patel, Seval Kilic, Metin Cetin, Sule Erdemir, Marta Salgado Navio, Maria Antonette Lopez, Nathan Curtis, Tamer Yagci, John N. Primrose, Brendan D. Price, Geert Berx, Gareth J. Thomas, Eugene Tulchinsky, Alex Mirnezami, A. Emre Sayan
Publikováno v:
Molecular Oncology, Vol 15, Iss 8, Pp 2065-2083 (2021)
Resistance to adjuvant chemotherapy is a major clinical problem in the treatment of colorectal cancer (CRC). The aim of this study was to elucidate the role of an epithelial to mesenchymal transition (EMT)‐inducing protein, ZEB2, in chemoresistance
Externí odkaz:
https://doaj.org/article/48e36438327a4d3b9ecc9732d773fccf
Autor:
Rahul Bhome, Muhammad Emaduddin, Victoria James, Louise M. House, Stephen M. Thirdborough, Massimiliano Mellone, Joeri Tulkens, John N. Primrose, Gareth J. Thomas, Olivier De Wever, Alex H. Mirnezami, A. Emre Sayan
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 5, Pp n/a-n/a (2022)
Abstract Colorectal cancer (CRC) with a mesenchymal gene expression signature has the greatest propensity for distant metastasis and is characterised by the accumulation of cancer‐associated fibroblasts in the stroma. We investigated whether the ep
Externí odkaz:
https://doaj.org/article/f0842c0e9e5141979abad1b36106ae4d
Autor:
Johannes Doescher, Adrian von Witzleben, Konstantinos Boukas, Stephanie E. Weissinger, Gareth J. Thomas, Simon Laban, Jaya Thomas, Thomas K. Hoffmann, Christian H. Ottensmeier
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Chemoradiotherapy (CRT) is a standard treatment for advanced head and neck squamous cell carcinoma (HNSCC). Unfortunately, not all patients respond to this therapy and require further treatment, either salvage surgery or palliative therapy. The addit
Externí odkaz:
https://doaj.org/article/0f6a2dfd86bf46f089d4d00e59c62b60
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with evidence suggesting they represent a heterogeneous population. This study summarises the prognostic role of all proteins characterised in CAFs with
Externí odkaz:
https://doaj.org/article/e5c522e948c04a42ab5034d979c930e4
Autor:
Chuan Wang, Nur Syafinaz Zainal, San Jiun Chai, James Dickie, Chai Phei Gan, Natasha Zulaziz, Bryan Kit Weng Lye, Ruhcha V. Sutavani, Christian H. Ottensmeier, Emma V. King, Mannil Thomas Abraham, Siti Mazlipah binti Ismail, Shin Hin Lau, Thomas George Kallarakkal, Kein Seong Mun, Rosnah binti Zain, Zainal Ariff Abdul Rahman, Gareth J. Thomas, Sok Ching Cheong, Natalia Savelyeva, Kue Peng Lim
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
HPV-independent head and neck squamous cell carcinoma (HNSCC) is a common cancer globally. The overall response rate to anti-PD1 checkpoint inhibitors (CPIs) in HNSCC is ~16%. One major factor influencing the effectiveness of CPI is the level of tumo
Externí odkaz:
https://doaj.org/article/4e3b57700cad491b8b3126170d014e2b