Zobrazeno 1 - 10
of 224
pro vyhledávání: '"Gareth J. Sanger"'
Autor:
Nicholas Baidoo, Gareth J. Sanger
Publikováno v:
Experimental and Molecular Pathology, Vol 139, Iss , Pp 104923- (2024)
Background & aims: Older people experience a greater incidence of lower bowel disorders, including constipation. Causes can include factors associated with growing older, such as use of medications or disease, but compounded by degenerative changes w
Externí odkaz:
https://doaj.org/article/77c983507d7e48f49989a33a3b1f5f09
Publikováno v:
MethodsX, Vol 11, Iss , Pp 102416- (2023)
Collagen is the most abundant structural protein and extracellular matrix component in mammals. In the colon, collagen fibres reside in all the major sublayers; namely, the mucosa, submucosa, muscularis externa and the serosa. Methods to quantify col
Externí odkaz:
https://doaj.org/article/18ec1d50c7a446479f4ea1ede2f29516
Autor:
Marilisa Straface, Marie-Ange Kouassi, Raj Makwana, Ellie Crawley, Alexandra Palmer, Weigang Cai, Armen Gharibans, Miriam Adebibe, John Loy, Greg O’Grady, Paul LR Andrews, Gareth J. Sanger
Publikováno v:
Pharmacological Research, Vol 180, Iss , Pp 106247- (2022)
Electrical slow waves, generated by interstitial cells of Cajal (ICC), cause spontaneous contractions of human stomach. Software was developed to measure muscle tone and eleven different parameters defining these contractions in human stomach, displa
Externí odkaz:
https://doaj.org/article/6545b2f4a9034b76bc76a3087d12427a
Autor:
Gareth J. Sanger
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 2, Pp n/a-n/a (2022)
Abstract The gastrointestinal (GI) hormone motilin helps control human stomach movements during hunger and promotes hunger. Although widely present among mammals, it is generally accepted that in rodents the genes for motilin and/or its receptor have
Externí odkaz:
https://doaj.org/article/dc819d461e544936933a215f97be4bca
Publikováno v:
Current Research in Pharmacology and Drug Discovery, Vol 3, Iss , Pp 100138- (2022)
The rationale for using thalidomide (THD) as a treatment for nausea and vomiting during pregnancy in the late 1950s appears to have been based on its sedative or hypnotic properties. In contrast to contemporaneous studies on the anti-emetic activity
Externí odkaz:
https://doaj.org/article/f182818659954f80941417ac2bfc0d24
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
Background The effect of ageing on total collagen content of human colon has been poorly investigated. The aim of this study was to determine if ageing altered total collagen content and distribution in the human colon. Methods Macroscopically normal
Externí odkaz:
https://doaj.org/article/054de45902e145b88e9c87c9aae84d8e
Autor:
Alexandra Palmer, Sarah Epton, Ellie Crawley, Marilisa Straface, Luke Gammon, Meghan M. Edgar, Yichen Xu, Shezan Elahi, Joanne Chin-Aleong, Joanne E. Martin, Cleo L. Bishop, Charles H. Knowles, Gareth J. Sanger
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Human colonic neuromuscular functions decline among the elderly. The aim was to explore the involvement of senescence. A preliminary PCR study looked for age-dependent differences in expression of CDKN1A (encoding the senescence-related p21 protein)
Externí odkaz:
https://doaj.org/article/c1614b0af08f4e7a8d86d2f172e7060a
Autor:
John Broad, Nobuyuki Takahashi, Masaomi Tajimi, Masaki Sudo, Adam Góralczyk, Umesh Parampalli, Kesava Mannur, Toshinori Yamamoto, Gareth J. Sanger
Publikováno v:
Journal of Pharmacological Sciences, Vol 130, Iss 2, Pp 60-65 (2016)
The aim was to characterise RQ-00201894, a novel non-macrolide motilin agonist, using human recombinant receptors and then investigate its ability to facilitate cholinergic activity in human stomach. A reporter gene assay assessed motilin receptor fu
Externí odkaz:
https://doaj.org/article/f635d8a8c56549dfabfbcb812b73f3c9
Autor:
Gareth J. Sanger, Paul L. R. Andrews
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
The origins of the major classes of current anti-emetics are examined. Serendipity is a recurrent theme in discovery of their anti-emetic properties and repurposing from one indication to another is a continuing trend. Notably, the discoveries have o
Externí odkaz:
https://doaj.org/article/2a6d784ce1c24dcd9804c1a095c6d92a
Publikováno v:
Therapeutic Advances in Gastroenterology, Vol 3 (2010)
Functional gastrointestinal disorders, such as irritable bowel syndrome and functional dyspepsia, are complex conditions with multiple factors contributing to their pathophysiology. As a consequence they are difficult to treat and have posed signific
Externí odkaz:
https://doaj.org/article/e9bfadda049c4a51b7c28abe157f065a