Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Gareth J. Miles"'
Autor:
Constantinos Demetriou, Naila Abid, Michael Butterworth, Larissa Lezina, Pavandeep Sandhu, Lynne Howells, Ian R. Powley, James H. Pringle, Zahirah Sidat, Omar Qassid, Dave Purnell, Monika Kaushik, Kaitlin Duckworth, Helen Hartshorn, Anne Thomas, Jacqui A. Shaw, Marion MacFarlane, Catrin Pritchard, Gareth J. Miles
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Breast Cancer is the most common cancer among women globally. Despite significant improvements in overall survival, many tumours are refractory to therapy and so novel approaches are required to improve patient outcomes. We have evaluated pa
Externí odkaz:
https://doaj.org/article/e0e42b354faf4f46a4b07334d5c51938
Autor:
Xiao-Ming Sun, Gareth J Miles, Ian R Powley, Andrew Craxton, Sarah Galavotti, Tatyana Chernova, Alan Dawson, Apostolos Nakas, Anne E Willis, Kelvin Cain, Marion MacFarlane
Malignant pleural mesothelioma (MPM) is an aggressive malignancy linked to asbestos exposure and highly resistant to chemotherapy, potentially due to upregulated expression of the pro-survival proteins, BCL2/BCL-XL/MCL-1. Using clinically-relevant mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98277997b6932d4c9836a4416bc5604c
https://doi.org/10.1101/2023.03.31.534530
https://doi.org/10.1101/2023.03.31.534530
Autor:
Marion MacFarlane, Lynne M. Howells, Catrin Pritchard, Gareth J Miles, J. Howard Pringle, Ian R. Powley, Seid Mohammed, Tim Hammonds
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology
Patient Derived Explants (PDEs) represent the direct culture of fragments of freshly-resected tumour tissue under conditions that retain the original architecture of the tumour. PDEs have advantages over other preclinical cancer models as platforms f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412330c3baae21d9acb9e88e4a22b0de
https://doi.org/10.1038/s41374-020-00511-3
https://doi.org/10.1038/s41374-020-00511-3
Autor:
Marion MacFarlane, Gareth J Miles, Esther L. Moss, Ian R. Powley, Catrin Pritchard, Roger Hew, J. Howard Pringle, Anna Collins
Publikováno v:
Gynecologic Oncology. 160:557-567
Objective To undertake a pilot study to develop a novel Patient-Derived-Explant (PDE) model system for use in endometrial cancer (EC) that is capable of monitoring differential drug responses in a pre-clinical setting. Methods Fresh tumour was obtain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::988388ad592bd3b18878a741966ca307
https://doi.org/10.1016/j.ygyno.2020.11.033
https://doi.org/10.1016/j.ygyno.2020.11.033
Autor:
Marion MacFarlane, Catherine A. Kettleborough, Catrin Pritchard, Meeta Patel, Lynne M. Howells, Justin S. Bryans, Tim Hammonds, Howard Pringle, Ian R. Powley, Anne Thomas, Gareth J Miles
Publikováno v:
British Journal of Cancer
Preclinical models that can accurately predict outcomes in the clinic are much sought after in the field of cancer drug discovery and development. Existing models such as organoids and patient-derived xenografts have many advantages, but they suffer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b649246742dcd33f3cf3bc3d72e81e1f
https://doi.org/10.1038/s41416-019-0672-6
https://doi.org/10.1038/s41416-019-0672-6
Autor:
Gareth J Miles, Marion MacFarlane, Anna Collins, Joanna P. Wood, Catrin Pritchard, Esther L. Moss
Publikováno v:
Gynecologic Oncology. 156:251-259
The majority of endometrial cancers are detected early with a favourable prognosis. However, for patients with advanced disease, chemotherapy response rates and overall survival remains poor. The endometrial cancer population is typically elderly wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62daabeabe66aa2856719adb15af6e0f
https://doi.org/10.1016/j.ygyno.2019.11.020
https://doi.org/10.1016/j.ygyno.2019.11.020
Autor:
Sam Khan, Gareth J Miles, Constantinos Demetriou, Zahirah Sidat, Nalini Foreman, Kevin West, Ankur Karmokar, Lynne Howells, Catrin Pritchard, Anne L Thomas, Karen Brown
Publikováno v:
Mutagenesis. 37(5-6)
Colorectal cancer (CRC) is the second leading cause of cancer death in the UK. Novel therapeutic prevention strategies to inhibit the development and progression of CRC would be invaluable. Potential contenders include low toxicity agents such as die
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d837383c4c1828c38bedcb0c263e034c
https://pubmed.ncbi.nlm.nih.gov/36426854
https://pubmed.ncbi.nlm.nih.gov/36426854
Autor:
Catrin Pritchard, Lynne M. Howells, Meeta Patel, Howard Pringle, Michael Butterworth, Ian R. Powley, James Cooper, Constantinos Demetriou, Marion MacFarlane, Giuditta Viticchiè, Gareth J Miles, Naila Abid
Publikováno v:
Journal of Visualized Experiments.
An understanding of drug resistance and the development of novel strategies to sensitize highly resistant cancers rely on the availability of suitable preclinical models that can accurately predict patient responses. One of the disadvantages of exist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c66d5e261266960f14acf066e5ba17
https://doi.org/10.3791/62130-v
https://doi.org/10.3791/62130-v
Autor:
Janella de Jesus, Catia Costa, Ellie Karekla, Calum J. Greenhalgh, Catrin Pritchard, Melanie J. Bailey, Marion MacFarlane, J. Howard Pringle, Amy J. Managh, Gareth J. Miles, Ian R. Powley
Publikováno v:
Analytical chemistry. 92(14)
The use of a low aerosol dispersion ablation chamber within a laser ablation inductively coupled plasma mass spectrometer (LA-ICP-MS) setup allows for high-resolution, high-speed imaging of the distribution of elements within a sample. Here we show h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2ae09de803ee2b56cb7f368384909a
https://pubmed.ncbi.nlm.nih.gov/32545955
https://pubmed.ncbi.nlm.nih.gov/32545955
Publikováno v:
Poster exhibition Day 2.
Introduction/Background Adjuvant chemotherapy confers a modest advantage in progression free and overall survival in endometrial cancer (EC). Response rates to primary chemotherapy regimens are reported as low as 17–36%1. Pre-clinical models that b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8adc7580b4753ece957779e9bee4e5e2
https://doi.org/10.1136/ijgc-2019-esgo.231
https://doi.org/10.1136/ijgc-2019-esgo.231