Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Gareth J. Howell"'
Autor:
Margherita Bertuzzi, Gareth J. Howell, Darren D. Thomson, Rachael Fortune-Grant, Anna Möslinger, Patrick Dancer, Norman Van Rhijn, Natasha Motsi, Alice Codling, Elaine M. Bignell
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109939- (2024)
Summary: Hundreds of spores of Aspergillus fumigatus (Af) are inhaled daily by human beings, representing a constant, possibly fatal, threat to respiratory health. The small size of Af spores suggests that interactions with alveolar epithelial cells
Externí odkaz:
https://doaj.org/article/ff7b9b1ee6e3455b85a6661245bccc68
Autor:
Freya R. Svedberg, Tracy Hussell, Christopher M. Evans, Peter C. Cook, Maryam Clausen, Sheila Brown, Maria Z Krauss, Gareth J. Howell, Richard K. Grencis, Danen Cunoosamy, Alasdair Ivens, Jens Madsen, Laura Campbell, Howard Clark, Andrew S. MacDonald, David J. Thornton, Catherine Sharpe, Tara E. Sutherland
Publikováno v:
Nat Immunol
Svedberg, F R, Brown, S L, Krauss, M Z, Campbell, L, Sharpe, C, Clausen, M, Howell, G J, Clark, H, Madsen, J, Evans, C M, Sutherland, T E, Ivens, A C, Thornton, D J, Grencis, R K, Hussell, T, Cunoosamy, D M, Cook, P C & MacDonald, A S 2019, ' The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation ', Nature Immunology, vol. 20, no. 5, pp. 571-580 . https://doi.org/10.1038/s41590-019-0352-y
Svedberg, F R, Brown, S L, Krauss, M Z, Campbell, L, Sharpe, C, Clausen, M, Howell, G J, Clark, H, Madsen, J, Evans, C M, Sutherland, T E, Ivens, A C, Thornton, D J, Grencis, R K, Hussell, T, Cunoosamy, D M, Cook, P C & MacDonald, A S 2019, ' The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation ', Nature Immunology, vol. 20, no. 5, pp. 571-580 . https://doi.org/10.1038/s41590-019-0352-y
Fine control of macrophage activation is needed to prevent inflammatory disease, particularly at barrier sites such as the lungs.However, the dominant mechanisms that regulate the activation of pulmonary macrophages during inflammation are poorly und
Autor:
Margherita, Bertuzzi, Gareth J, Howell
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2260
The respiratory epithelium is the initial point of host contact for inhaled particles, leading to orchestrated, but highly heterogeneous, responses. Human airway epithelial cells (AECs) play a crucial role in host defense by promoting uptake and kill
Autor:
Alexandra L. Ball, John P Stone, Nizar Yonan, William R. Critchley, James E. Fildes, Gareth J. Howell, Kavit Amin, Rebecca J. Edge
Publikováno v:
Transplant immunology. 64
Background Donor leukocytes are intrinsically involved in acute lung allograft rejection, via self-presentation of donor antigens to recipient leukocytes. Therapeutic modalities to remove donor leukocytes are currently unavailable. We evaluated if a
Autor:
Alexander F Bruns, Nadira Yuldasheva, Antony M Latham, Leyuan Bao, Caroline Pellet-Many, Paul Frankel, Sam L Stephen, Gareth J Howell, Stephen B Wheatcroft, Mark T Kearney, Ian C Zachary, Sreenivasan Ponnambalam
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48539 (2012)
Vascular endothelial growth factor A (VEGF-A) binds to the VEGFR2 receptor tyrosine kinase, regulating endothelial function, vascular physiology and angiogenesis. However, the mechanism underlying VEGFR2 turnover and degradation in this response is u
Externí odkaz:
https://doaj.org/article/ff0c1fd3df0a4c32abd57c81bdba2714
Autor:
Upasana Mandal, Jianxin Duan, Thembaninskosi Gaule, Darren C. Tomlinson, Eric Feyfant, David J. Hughes, Michael J. McPherson, Gareth J. Howell, Christian Tiede, Thomas A. Edwards, Katarzyna Z. Zajac, Anna A Tang, Chi H. Trinh, Natalie Penswick, Adrian Whitehouse
Publikováno v:
Science Signaling. 10
This work was funded in part by a Leeds Cancer Research UK (CRUK) Development Fund and The Wellcome Trust (ISSF) (DJH), The Wellcome Trust (089330), BBSRC (BB/K000306/1 and BB/M006557/1) (AW) and The University of Leeds through Biomedical Health Rese
Autor:
Rachel Wheat, Andrew Macdonald, Jennifer J. Wood, G. E. Blair, Neil Steven, Adrian Whitehouse, Laura M. Knight, Hussein K . Abdul-Sada, DA Griffiths, G Stakaityte, Gareth J. Howell, David J. Blackbourn
Publikováno v:
Journal of Virology
Merkel cell carcinoma (MCC) is an aggressive skin cancer of neuroendocrine origin with a high propensity for recurrence and metastasis. Merkel cell polyomavirus (MCPyV) causes the majority of MCC cases due to the expression of the MCPyV small and lar
Autor:
Matthew A. Hannah, Christine H. Foyer, Ambra de Simone, Guillaume Queval, Matome Eugene Makgopa, Gareth J. Howell, Juan Bai, Daniel Schnaubelt, Yingping Dong, Pedro Diaz-Vivancos
Publikováno v:
Plant, Cell & Environment. 38:266-279
Reduced glutathione (GSH) is considered to exert a strong influence on cellular redox homeostasis and to regulate gene expression, but these processes remain poorly characterized. Severe GSH depletion specifically inhibited root meristem development,
Autor:
Zoe G. Holloway, Antonio Velayos-Baeza, Gareth J. Howell, C Levecque, Sreenivasan Ponnambalam, Elizabeth Sztul, Anthony P. Monaco
Publikováno v:
Molecular Biology of the Cell
ATP7A mediates copper absorption and feeds cuproenzymes in the trans-Golgi network. To regulate copper homeostasis, ATP7A cycles between the TGN and plasma membrane. The roles of clathrin, adaptor complexes, lipid rafts, and Rab22a are assessed in an
Autor:
Gareth J. Howell, Stephen P. Muench, Michael A. Harrison, Sreenivasan Ponnambalam, Gina A. Smith, Clair Phillips
Publikováno v:
The Journal of Biological Chemistry
Plasma membrane vacuolar H(+)-ATPase (V-ATPase) activity of tumor cells is a major factor in control of cytoplasmic and extracellular pH and metastatic potential, but the isoforms involved and the factors governing plasma membrane recruitment remain