Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Gareth J. Griffiths"'
Autor:
Gareth J. Griffiths
Publikováno v:
CHIMIA, Vol 51, Iss 6 (1997)
A novel preparation of 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde, a key intermediate for the synthesis of the angiotensin II antagonist Losartan potassium, via Vilsmeier chloroformylation of imidazolinone is described.
Externí odkaz:
https://doaj.org/article/76fa978ee58a4dc29b9e71870e3a02ff
Autor:
Gareth J. Griffiths, Dominic I. James, Beth Dyson, Immaculate M. Nalubowa, Apostolos Nakas, Paul Baas, Zsuzsanna Tabi, Min Zhang, Qianqian Sun, Daniel Faulkner, Nada Nusrat, Essa Y. Baitei, Joanna Dzialo, Alan Dawson, Charlotte Poile, Jake Spicer, Aleksandra Bzura, Jin-Li Luo, Hongji Yang, Cathy Richards, Dean A. Fennell
Publikováno v:
Cancer Research. 82:1613-1613
Mesothelioma is a rare, lethal cancer caused by asbestos. Despite recent advances molecularly stratified therapy is lacking, in part due to the challenge of targeting the preponderance of tumor suppressors. Recent efforts to select therapy from our g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98927596f10df3e62c11114ed5641ab2
https://doi.org/10.1158/1538-7445.am2022-1613
https://doi.org/10.1158/1538-7445.am2022-1613
Autor:
Immaculate Nalubowa, Subir Singh, Yuen Ngan Fan, Rachel Howard-Jones, Albert Bezman, Dominic I. James, Geoff Muckle, Gareth J. Griffiths
Publikováno v:
Molecular Cancer Therapeutics. 20:P119-P119
Female breast cancer (BC) became the most commonly diagnosed cancer globally in 2020. One of the hallmarks of BC is both intratumor and intertumor heterogeneity. Efforts have been made to categorize this heterogeneity based on the presence or absence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be44fbe20a8394ae4147d44d41c5d6c8
https://doi.org/10.1158/1535-7163.targ-21-p119
https://doi.org/10.1158/1535-7163.targ-21-p119
Autor:
Aleksander Warm, Gareth J. Griffiths
Publikováno v:
Organic Process Research & Development. 20:803-813
The rationalization of observations made during optimization of the zinc-mediated enantioselective addition of cyclopropylacetylene (2) to ketoaniline 8 in the presence of (1R,2S)-1-phenyl-2-(pyrrolidin-1-yl)propan-1-ol (3) to afford amino alcohol 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a7d14b715cb2ad91d993c943b83b246
https://doi.org/10.1021/acs.oprd.6b00058
https://doi.org/10.1021/acs.oprd.6b00058
Autor:
Jayesh Trivedi, Gareth J. Griffiths, Karina T. Wright, Jennifer J. Bara, Sally Roberts, Sarah Turner, Rod Benson
Publikováno v:
Experimental Cell Research. 333:93-104
Mesenchymal stem cells are universally regarded across many fields of medicine, as one of the most promising cell types for use in cell-based therapies. Although not yet fully understood, the therapeutic effects of these cells are largely attributed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e14bb269e10ff853bc7ff5f6378fe30c
https://doi.org/10.1016/j.yexcr.2014.12.019
https://doi.org/10.1016/j.yexcr.2014.12.019
Publikováno v:
SLAS Discovery. 15:576-582
Bone marrow mesenchymal stem cells (MSCs) promote nerve growth and functional recovery in animal models of spinal cord injury (SCI) to varying levels. The authors have tested high-content screening to examine the effects of MSC-conditioned medium (MS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67755980150aee4d862c3731d79f0df
https://doi.org/10.1177/1087057110367959
https://doi.org/10.1177/1087057110367959
Autor:
Gareth J. Griffiths, Jane Barraclough, Arkadiusz Welman, Christopher Cawthorne, Judith C. Williams, Ian J. Stratford, Caroline Dive, Nigel K Smith, Rachel L. Cowen
Publikováno v:
Journal of Cellular Biochemistry. 94:1148-1162
Validation of targets for cancer drug discovery requires robust experimental models. Systems based on inducible gene expression are well suited to this purpose but are difficult to establish in several epithelial cell types. Using the recently discov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b6d44940ffc16870bf6381f4a51123a
https://doi.org/10.1002/jcb.20342
https://doi.org/10.1002/jcb.20342
Autor:
Valerie G Brunton, Gareth J. Griffiths, Christopher Cawthorne, Natalie A Reeves, Michael J. Tilby, Margaret C. Frame, Martin J Greaves, Paul Workman, Caroline Dive, D. Graham Pearson, Chris J. Ottley, Mei Yee Koh
Publikováno v:
Journal of Biological Chemistry. 279:46113-46121
Tumor resistance to current drugs prevents curative treatment of human colon cancer. A pressing need for effective, tumor-specific chemotherapies exists. The non-receptor-tyrosine kinase c-Src is overexpressed in70% of human colon cancers and represe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5bcc029b9b1f0b30eabb2240792ddba
https://doi.org/10.1074/jbc.m408550200
https://doi.org/10.1074/jbc.m408550200
Publikováno v:
e-EROS Encyclopedia of Reagents for Organic Synthesis
(R = p-tolyl) [19158-51-1] C8H7NO2S (MW 181.23) InChI = 1S/C8H7NO2S/c1-7-2-4-8(5-3-7)12(10,11)6-9/h2-5H,1H3 InChIKey = JONIMGVUGJVFQD-UHFFFAOYSA-N (R = methyl) [24225-08-9] C2H3NO2S (MW 105.13) InChI = 1S/C2H3NO2S/c1-6(4,5)2-3/h1H3 InChIKey = QEIOAAJ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b4e626c75153730c57fd40a77c87f7d
https://doi.org/10.1002/047084289x.rt136m.pub2
https://doi.org/10.1002/047084289x.rt136m.pub2
Publikováno v:
Journal of Integrated OMICS. 4
Keratins form the intermediate filament (IF) component of the epithelial cytoskeleton. Depolymerisation of these filaments causes the cell to collapse and become more plastic. We have previously shown that short chain fatty acids may trigger depolyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2d6bd2bd465f62fe0b1703a036bd30d
https://doi.org/10.5584/jiomics.v4i1.159
https://doi.org/10.5584/jiomics.v4i1.159