Zobrazeno 1 - 10
of 359
pro vyhledávání: '"Gareth J Thomas"'
Autor:
Gareth J Thomas, Saul N Faust, Christopher Kipps, Hang Phan, Florina Borca, Sarah Williams, Tom Wilkinson, Hannah Burke, Anna Freeman, Ahilanandan Dushianthan, Michael Celinski, James Batchelor, Natasha Sheard, Paul Fitzpatrick, Dónal Landers
Publikováno v:
BMJ Open, Vol 11, Iss 1 (2021)
Introduction The COVID-19 pandemic caused by SARS-CoV-2 places immense worldwide demand on healthcare services. Earlier identification of patients at risk of severe disease may allow intervention with experimental targeted treatments, mitigating the
Externí odkaz:
https://doaj.org/article/912650ad59864fc49299b66d495a79db
Autor:
Liku B Tezera, Magdalena K Bielecka, Paul Ogongo, Naomi F Walker, Matthew Ellis, Diana J Garay-Baquero, Kristian Thomas, Michaela T Reichmann, David A Johnston, Katalin Andrea Wilkinson, Mohamed Ahmed, Sanjay Jogai, Suwan N Jayasinghe, Robert J Wilkinson, Salah Mansour, Gareth J Thomas, Christian H Ottensmeier, Alasdair Leslie, Paul T Elkington
Publikováno v:
eLife, Vol 9 (2020)
Previously, we developed a 3-dimensional cell culture model of human tuberculosis (TB) and demonstrated its potential to interrogate the host-pathogen interaction (Tezera et al., 2017a). Here, we use the model to investigate mechanisms whereby immune
Externí odkaz:
https://doaj.org/article/26d53fc70a4d49198d9cbc54c4787117
Autor:
Zoé Vincent-Mistiaen, Ahmed Elbediwy, Hannah Vanyai, Jennifer Cotton, Gordon Stamp, Emma Nye, Bradley Spencer-Dene, Gareth J Thomas, Junhao Mao, Barry Thompson
Publikováno v:
eLife, Vol 7 (2018)
Squamous cell carcinoma (SCC) can progress to malignant metastatic cancer, including an aggressive subtype known as spindle cell carcinoma (spSCC). spSCC formation involves epithelial-to-mesenchymal transition (EMT), yet the molecular basis of this e
Externí odkaz:
https://doaj.org/article/6de980c2e1784fdbabf6b0279c684b74
Autor:
Alison Caldwell, Rachel Coleby, Cesar Tovar, Maximilian R Stammnitz, Young Mi Kwon, Rachel S Owen, Marios Tringides, Elizabeth P Murchison, Karsten Skjødt, Gareth J Thomas, Jim Kaufman, Tim Elliott, Gregory M Woods, Hannah VT Siddle
Publikováno v:
eLife, Vol 7 (2018)
Devil Facial Tumour 2 (DFT2) is a recently discovered contagious cancer circulating in the Tasmanian devil (Sarcophilus harrisii), a species which already harbours a more widespread contagious cancer, Devil Facial Tumour 1 (DFT1). Here we show that i
Externí odkaz:
https://doaj.org/article/c663c7cb985647848f8b82ddf986bf32
Autor:
Heide Kogelberg, Enrique Miranda, Jerome Burnet, David Ellison, Berend Tolner, Julie Foster, Carmen Picón, Gareth J Thomas, Tim Meyer, John F Marshall, Stephen J Mather, Kerry Chester
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73260 (2013)
The αvβ6 integrin is up-regulated in cancer and wound healing but it is not generally expressed in healthy adult tissue. There is increasing evidence that it has a role in cancer progression and will be a useful target for antibody-directed cancer
Externí odkaz:
https://doaj.org/article/0c61c724ed5c43909ee33c38c74ecb35
Autor:
Sandeep K Nadendla, Allon Hazan, Matt Ward, Lisa J Harper, Karwan Moutasim, Lucia S Bianchi, Mahmoud Naase, Lucy Ghali, Gareth J Thomas, David M Prowse, Michael P Philpott, Graham W Neill
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20271 (2011)
The GLI (GLI1/GLI2) transcription factors have been implicated in the development and progression of prostate cancer although our understanding of how they actually contribute to the biology of these common tumours is limited. We observed that GLI re
Externí odkaz:
https://doaj.org/article/365ae24beb2e41ba800a69cc8387d6b0
Autor:
Gabriela D'Amico, Stephen D Robinson, Mitchel Germain, Louise E Reynolds, Gareth J Thomas, George Elia, Garry Saunders, Marcus Fruttiger, Victor Tybulewicz, Georgia Mavria, Kairbaan M Hodivala-Dilke
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9766 (2010)
Endothelial cell migration is an essential aspect of tumor angiogenesis. Rac1 activity is needed for cell migration in vitro implying a requirement for this molecule in angiogenesis in vivo. However, a precise role for Rac1 in tumor angiogenesis has
Externí odkaz:
https://doaj.org/article/41b0c7cc9f614c6dbf5291476797a248
Autor:
Philip J. Basford, Orestis L. Katsamenis, Richard P. Boardman, Stephanie K. Robinson, Peter M. Lackie, Elena Konstantinopoulou, J. Arjuna Ratnayaka, Anton Page, Gareth J. Thomas, Patricia M. Goggin, Ian Sinclair, Simon J. Cox, Philipp Schneider
Publikováno v:
Wellcome Open Research, Vol 8 (2023)
Background The University of Southampton, in collaboration with the University Hospital Southampton (UHS) NHS Foundation Trust and industrial partners, has been at the forefront of developing three-dimensional (3D) imaging workflows using X-ray micro
Externí odkaz:
https://doaj.org/article/b0eca1b24de04d559f74a9f42a48df65
Autor:
Christopher J. Hanley, Sara Waise, Matthew J. Ellis, Maria A. Lopez, Wai Y. Pun, Julian Taylor, Rachel Parker, Lucy M. Kimbley, Serena J. Chee, Emily C. Shaw, Jonathan West, Aiman Alzetani, Edwin Woo, Christian H. Ottensmeier, Matthew J. J. Rose-Zerilli, Gareth J. Thomas
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Fibroblast heterogeneity is a prominent but poorly understood feature of solid tumours. Here three major fibroblast subpopulations in non-small cell lung cancer are identified and characterised through single cell RNA-sequencing, multiplexed immunohi
Externí odkaz:
https://doaj.org/article/90c9737e349b4a0f860180335c1700ab
Autor:
Ankur Chakravarthy, Ian Reddin, Stephen Henderson, Cindy Dong, Nerissa Kirkwood, Maxmilan Jeyakumar, Daniela Rothschild Rodriguez, Natalia Gonzalez Martinez, Jacqueline McDermott, Xiaoping Su, Nagayasau Egawa, Christina S. Fjeldbo, Vilde Eide Skingen, Heidi Lyng, Mari Kyllesø Halle, Camilla Krakstad, Afschin Soleiman, Susanne Sprung, Matt Lechner, Peter J. I. Ellis, Mark Wass, Martin Michaelis, Heidi Fiegl, Helga Salvesen, Gareth J. Thomas, John Doorbar, Kerry Chester, Andrew Feber, Tim R. Fenton
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Human papillomavirus (HPV) is a known cause of cervical cancer. Here, the authors perform a multi-omic analysis using published cervical squamous cell carcinoma cohorts from the USA, Europe, and SubSaharan Africa and identify two cervical squamous ce
Externí odkaz:
https://doaj.org/article/9a5c4607e718467ca9be497358a18ce0