Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Gareth J Sullivan"'
Models and Techniques to Study Aortic Valve Calcification in Vitro, ex Vivo and in Vivo. An Overview
Autor:
Maria Bogdanova, Arsenii Zabirnyk, Anna Malashicheva, Daria Semenova, John-Peder Escobar Kvitting, Mari-Liis Kaljusto, Maria del Mar Perez, Anna Kostareva, Kåre-Olav Stensløkken, Gareth J Sullivan, Arkady Rutkovskiy, Jarle Vaage
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Aortic valve stenosis secondary to aortic valve calcification is the most common valve disease in the Western world. Calcification is a result of pathological proliferation and osteogenic differentiation of resident valve interstitial cells. To devel
Externí odkaz:
https://doaj.org/article/bee968d2f14e495b851a83949d91c8bb
Publikováno v:
Cell Reports, Vol 30, Iss 6, Pp 1682-1689.e3 (2020)
Summary: Human brain organoid systems offer unprecedented opportunities to investigate both neurodevelopmental and neurological disease. Single-cell-based transcriptomics or epigenomics have dissected the cellular and molecular heterogeneity in the b
Externí odkaz:
https://doaj.org/article/5503410fcf7c4ee49349961dce7adcaf
Autor:
Kun-Yong Kim, Yoshiaki Tanaka, Juan Su, Bilal Cakir, Yangfei Xiang, Benjamin Patterson, Junjun Ding, Yong-Wook Jung, Ji-Hyun Kim, Eriona Hysolli, Haelim Lee, Rana Dajani, Jonghwan Kim, Mei Zhong, Jeong-Heon Lee, David Skalnik, Jeong Mook Lim, Gareth J. Sullivan, Jianlong Wang, In-Hyun Park
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Uhrf1 is a known regulator of heterochromatin and DNA methylation in embryonic stem cells (ESCs). Here, the authors demonstrate that Uhrf1 acts together with the Set1/COMPASS complex regulator of active transcription to promote H3K4 methylation at bi
Externí odkaz:
https://doaj.org/article/de5d0fb025b047ba960f4909f2822905
Autor:
Giacomo Roman, Benedicte Stavik, Knut H. Lauritzen, Per Morten Sandset, Sean P. Harrison, Gareth J. Sullivan, Maria Eugenia Chollet
Publikováno v:
Frontiers in Physiology. 14
The bleeding phenotype of hereditary coagulation disorders is caused by the low or undetectable activity of the proteins involved in hemostasis, due to a broad spectrum of genetic alterations. Most of the affected coagulation factors are produced in
Publikováno v:
Stem Cell Reports, Vol 4, Iss 5, Pp 939-952 (2015)
The differentiation of pluripotent stem cells to hepatocytes is well established, yet current methods suffer from several drawbacks. These include a lack of definition and reproducibility, which in part stems from continued reliance on recombinant gr
Externí odkaz:
https://doaj.org/article/dfd2242b8b684930baa4ddd8d67a9fdc
Autor:
Xiaolin Lin, Wei Wang, Mingyi Yang, Nadirah Damseh, Mirta Mittelstedt Leal de Sousa, Fadi Jacob, Anna Lång, Elise Kristiansen, Marco Pannone, Miroslava Kissova, Runar Almaas, Anna Kuśnierczyk, Richard Siller, Maher Shahrour, Motee Al-Ashhab, Bassam Abu-Libdeh, Wannan Tang, Geir Slupphaug, Orly Elpeleg, Stig Ove Bøe, Lars Eide, Gareth J Sullivan, Johanne Egge Rinholm, Hongjun Song, Guo-li Ming, Barbara van Loon, Simon Edvardson, Jing Ye, Magnar Bjørås
We report a loss-of-function mutation in the TLDc domain of human Oxidation Resistance 1 (OXR1) gene, resulting in early-onset epilepsy, developmental delay, cognitive disabilities, and cerebellar atrophy. Patient lymphoblasts show impaired cell surv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80afcbf5e6d2745f37e96a8468e7e78f
https://doi.org/10.1101/2022.05.24.493324
https://doi.org/10.1101/2022.05.24.493324
Autor:
Armin Raznahan, Eric Courchesne, Andrea Parolin Jackowski, Kamen A. Tsvetanov, Cameron T. Ellis, R.C. Gur, Bin Bae J, Park Mtm, Pedro A. Valdes-Sosa, Simon N. Vandekar, Jacob W. Vogel, Juan Zhou, Machteld Marcelis, Kiho Im, Patricia Ellen Grant, Minhui Ouyang, Blesa Cabez M, Michael V. Lombardo, Sarah E. Morgan, James P. Boardman, Adamson C, Calhoun Vd, Delarue M, James H. Cole, Pichet Binette A, Roberto Toro, David H. Rowitch, Nynke A. Groenewold, Kevin M. Anderson, David T.W. Jones, Michael Schöll, Wang Ys, Aiden Corvin, R.E. Gur, Damien A. Fair, Gareth Ball, Herma Lina Schaare, Andrew Zalesky, Evdokia Anagnostou, Michael J. Meaney, Taki Y, Gareth J. Sullivan, Warrier, Petra E. Vértes, Chixiang Chen, Lisa T. Eyler, Wei Liao, Tomáš Paus, Jeremy A. Elman, Phillip McGuire, Hisham Ziauddeen, William S. Kremen, Etienne Vachon-Presseau, E.T. Bullmore, Christophe Tzourio, White, Hammill Cf, Mothersill D, Richard N. Henson, Jiang Qiu, Duncan E. Astle, Fabrice Crivello, Paul C. Fletcher, Chertavian C, Kim K, Jennifer Crosbie, Russell Schachar, Gabriel A. Devenyi, Manfred G. Kitzbichler, Tianye Jia, Trey Hedden, Sang Jae Lee, Ross D. Markello, Silke Kern, Ian M. Goodyer, Keith A. Johnson, Frauke Beyer, Bernard Mazoyer, A. Heinz, Sylvane Desrivières, Rosenberg, Gary Donohoe, Ong Mq, Alexander D. Edwards, Dan J. Stein, Nenad Medic, Zuo Xn, Travis T. Mallard, Peter Fonagy, Lindsay W. Victoria, Ingmar Skoog, Avram J. Holmes, Jason P. Lerch, Jed T. Elison, Jianfu Li, John H. Gilmore, Rosemary Holt, Caitlin K. Rollins, Carol E. Franz, Pedro Mario Pan, Saashi A Bedford, Yang N, Jonathan C Ipser, Richard A. I. Bethlehem, Tuulari Jj, Stolicyn A, Hua Huang, Bratislav Misic, Conor Liston, Ayub M, Lisa Ronan, Yeo Bt, Sophie Adler, Charles J. Lynch, Faith M. Gunning, Konrad Wagstyl, M. Mallar Chakravarty, John Suckling, Theodore D. Satterthwaite, Bharath Holla, Yap Seng Chong, Jinglei Lv, Jakob Seidlitz, Niall J Bourke, Xinlei Qian, Simon Baron-Cohen, Cynthia M. Ortinau, Deirel Paz Linares, Thyreau B, René S. Kahn, Aaron P. Schultz, Vanessa Cropley, Eric Westman, Mitchell Valdés-Sosa, Rik Ossenkoppele, André Zugman, Hasse Karlsson, Sylvia Villeneuve, Katja Heuer, Di Biase Ma, Margaret L. Westwater, Sofie L. Valk, David J. Sharp, Brigitte Landeau, Matthew Borzage, Kirsten A. Donald, Timothy Rittman, Richard Beare, Giovanni Abrahão Salum, Gunter Schumann, Ryuta Kawashima, Romero-Garcia R, John Blangero, Yun Hj, Russel T. Shinohara, Nicolas Crossley, Simon K. Warfield, Karen Pierce, George S. Alexopoulos, Katharine Dunlop, David C. Glahn, Francois Lalonde, Anqi Qiu, Lana Vasung, Gaël Chételat, Lídice Galán-García, Clifford R. Jack, Reisa A. Sperling, Anna Zettergren, Elizabeth Kelley, Arno Villringer, Andrea Mechelli, Benegal, Aaron Alexander-Bloch, Nicholas B. Turk-Browne, van Amelsvoort T, John D. Lewis, Heather C. Whalley, A. V. Witte, Zdenka Pausova, Joel T. Nigg, Heather J. Zar, Raymond J. Dolan, Christopher D. Smyser, Jay N. Giedd, Lena Palaniyappan, Ali Gholipour, Areces-Gonzalez A, Peter B. Jones, Jacqueline Hoare, Oskar Hansson, Linnea Karlsson, C Pantelis, Paly L, Bonnie Auyeung, Jorge Bosch-Bayard
Publikováno v:
Nature
Nature, 2022, 604 (7906), pp.525-533. ⟨10.1038/s41586-022-04554-y⟩
Nature 604(7906), 525-533 (2022). doi:10.1038/s41586-022-04554-y
Nature, 604(7906), 525-533. Nature Publishing Group
Neuroscience Institute Publications
2022, ' Brain charts for the human lifespan ', Nature . https://doi.org/10.1038/s41586-022-04554-y
3R-BRAIN, AIBL, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Repository Without Borders Investigators, CALM Team, Cam-CAN, CCNP, COBRE, cVEDA, ENIGMA Developmental Brain Age Working Group, Developing Human Connectome Project, FinnBrain, Harvard Aging Brain Study, IMAGEN, KNE96, Mayo Clinic Study of Aging, NSPN, POND, PREVENT-AD Research Group & VETSA 2022, ' Brain charts for the human lifespan ', Nature, vol. 604, no. 7906, pp. 525-533 . https://doi.org/10.1038/s41586-022-04554-y
Nature, 2022, 604 (7906), pp.525-533. ⟨10.1038/s41586-022-04554-y⟩
Nature
Nature, 604(7906), 525-533. Nature Publishing Group
Neuroscience Institute Publications
2022, ' Brain charts for the human lifespan ', Nature . https://doi.org/10.1038/s41586-022-04554-y
3R-BRAIN, AIBL, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Repository Without Borders Investigators, CALM Team, Cam-CAN, CCNP, COBRE, cVEDA, ENIGMA Developmental Brain Age Working Group, Developing Human Connectome Project, FinnBrain, Harvard Aging Brain Study, IMAGEN, KNE96, Mayo Clinic Study of Aging, NSPN, POND, PREVENT-AD Research Group & VETSA 2022, ' Brain charts for the human lifespan ', Nature, vol. 604, no. 7906, pp. 525-533 . https://doi.org/10.1038/s41586-022-04554-y
Over the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, no reference standards currently exist to quantify individual differences in neuroimaging metrics over time, in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8657baebf2a1bd5b6c7b712b1f04f933
https://www.repository.cam.ac.uk/handle/1810/336922
https://www.repository.cam.ac.uk/handle/1810/336922
Publikováno v:
Cell Reports, Vol 30, Iss 6, Pp 1682-1689.e3 (2020)
Cell reports
Cell reports
SUMMARY Human brain organoid systems offer unprecedented opportunities to investigate both neurodevelopmental and neurological disease. Single-cell-based transcriptomics or epigenomics have dissected the cellular and molecular heterogeneity in the br
Autor:
Kulbhushan Sharma, Nagham T. Asp, Sean Harrison, Richard Siller, Saphira F. Baumgarten, Swapnil Gupta, Maria E Chollet, Elisabeth Andersen, Gareth J. Sullivan, Anne Simonsen
Publikováno v:
Autophagy. 18(8)
Early events during development leading to exit from a pluripotent state and commitment toward a specific germ layer still need in depth understanding. Autophagy has been shown to play a crucial role in both development and differentiation. This stud
Autor:
Maria, Bogdanova, Arsenii, Zabirnyk, Anna, Malashicheva, Daria, Semenova, John-Peder Escobar, Kvitting, Mari-Liis, Kaljusto, Maria Del Mar, Perez, Anna, Kostareva, Kåre-Olav, Stensløkken, Gareth J, Sullivan, Arkady, Rutkovskiy, Jarle, Vaage
Publikováno v:
Frontiers in pharmacology. 13
Aortic valve stenosis secondary to aortic valve calcification is the most common valve disease in the Western world. Calcification is a result of pathological proliferation and osteogenic differentiation of resident valve interstitial cells. To devel