Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Gareth J Lycett"'
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 2, p e0011595 (2024)
Insecticide resistance is a serious threat to our ability to control mosquito vectors which transmit pathogens including malaria parasites and arboviruses. Understanding the underlying mechanisms is an essential first step in tackling the challenges
Externí odkaz:
https://doaj.org/article/52c5d4a0e1fc4c2ba57bddb4613cef1c
Autor:
Steven D Buckingham, Frederick A Partridge, Beth C Poulton, Benjamin S Miller, Rachel A McKendry, Gareth J Lycett, David B Sattelle
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 6, p e0008639 (2021)
Pyrethroid-impregnated nets have contributed significantly to halving the burden of malaria but resistance threatens their future efficacy and the pipeline of new insecticides is short. Here we report that an invertebrate automated phenotyping platfo
Externí odkaz:
https://doaj.org/article/646eab1af88341da972b15d8a84768ef
Autor:
Linda Grigoraki, Xavier Grau-Bové, Henrietta Carrington Yates, Gareth J Lycett, Hilary Ranson
Publikováno v:
eLife, Vol 9 (2020)
The surface of insects is coated in cuticular hydrocarbons (CHCs); variations in the composition of this layer affect a range of traits including adaptation to arid environments and defence against pathogens and toxins. In the African malaria vector,
Externí odkaz:
https://doaj.org/article/d321531903b54a369965d1fa37c47c75
Autor:
Frederick A. Partridge, Beth C. Poulton, Milly A. I. Lake, Rebecca A. Lees, Harry-Jack Mann, Gareth J. Lycett, David B. Sattelle
Publikováno v:
Molecules, Vol 26, Iss 20, p 6226 (2021)
Mosquito-borne viruses including dengue, Zika, and Chikungunya viruses, and parasites such as malaria and Onchocerca volvulus endanger health and economic security around the globe, and emerging mosquito-borne pathogens have pandemic potential. Howev
Externí odkaz:
https://doaj.org/article/340e9163f39e4e28ac0ad077f6287cf4
Autor:
Hanafy M. Ismail, Mark J. I. Paine, Rosemary Susan Lees, Adriana Adolfi, David Malone, Gareth J Lycett, Amalia Anthousi, Rhiannon A. E. Logan, Rachel Davies
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Fenazaquin, pyridaben, tolfenpyrad and fenpyroximate are Complex I inhibitors offering a new mode of action for insecticidal malaria vector control. However, extended exposure to pyrethroid based products such as long-lasting insecticidal nets (LLINs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbfac530e75072f19d68de4ad2f6381c
http://link.springer.com/article/10.1038/s41598-020-73267-x
http://link.springer.com/article/10.1038/s41598-020-73267-x
Autor:
Adriana Adolfi, Beth C Poulton, Hilary Ranson, Gareth J Lycett, Amalia Anthousi, Stephanie Macilwee
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Insecticide resistance in Anopheles gambiae mosquitoes can derail malaria control programs, and to overcome it, we need to discover the underlying molecular basis. Here, we characterize 3 genes most often associated with insecticide resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f015521c43000263f8995ff9d126ea82
http://europepmc.org/articles/PMC6926047
http://europepmc.org/articles/PMC6926047
Autor:
Hilary Ranson, John Vontas, Victoria A. Ingham, Amalia Anthousi, Gareth J Lycett, Nicholas J. Harding, Vassilis Douris, Marion Morris
Publikováno v:
Nature
Pyrethroid-impregnated bed nets have driven considerable reductions in malaria-associated morbidity and mortality in Africa since the beginning of the century1. The intense selection pressure exerted by bed nets has precipitated widespread and escala
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2e289e506341d193a06028bcc1375d2
http://europepmc.org/articles/PMC6974402
http://europepmc.org/articles/PMC6974402
Autor:
Harry-Jack Mann, Rebecca A. Lees, Frederick A. Partridge, Milly A.I. Lake, Gareth J Lycett, David B. Sattelle, Beth C Poulton
Publikováno v:
Molecules, Vol 26, Iss 6226, p 6226 (2021)
Molecules
Volume 26
Issue 20
Molecules
Volume 26
Issue 20
Mosquito-borne viruses including dengue, Zika and Chikungunya viruses as well as parasites such as malaria and Onchocerca volvulus endanger health and economic security around the globe and emerging mosquito-borne pathogens have pandemic potential. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa62ba602605070634b346fd4cccff95
https://www.mdpi.com/1420-3049/26/20/6226
https://www.mdpi.com/1420-3049/26/20/6226
Autor:
Hilary Ranson, Gareth J Lycett, Linda Grigoraki, Ruth Cowlishaw, Tony Nolan, Martin J. Donnelly
Publikováno v:
PLoS Genetics, Vol 17, Iss 7, p e1009556 (2021)
PLoS Genetics
PLoS Genetics
Insecticide resistance in Anopheles mosquitoes is a major obstacle in maintaining the momentum in reducing the malaria burden; mitigating strategies require improved understanding of the underlying mechanisms. Mutations in the target site of insectic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70b8d844a32b350fc4b0a7068f9e0f2
https://doaj.org/article/78b2aa5f95904443a63d71cfaab7ba77
https://doaj.org/article/78b2aa5f95904443a63d71cfaab7ba77
Autor:
Gareth J Lycett, Mary Kefi, Vassilis Douris, Vasileia Balabanidou, John Vontas, René Feyereisen
Publikováno v:
Kefi, M, Balabanidou, V, Douris, V, Lycett, G, Feyereisen, R & Vontas, J 2019, ' Two functionally distinct CYP4G genes of Anopheles gambiae contribute to cuticular hydrocarbon biosynthesis ', Insect Biochemistry and Molecular Biology, vol. 110, pp. 52-59 . https://doi.org/10.1016/j.ibmb.2019.04.018
Insect Biochemistry and Molecular Biology
Insect Biochemistry and Molecular Biology
Cuticular hydrocarbon (CHC)biosynthesis is a major pathway of insect physiology. In Drosophila melanogaster the cytochrome P450 CYP4G1 catalyses the insect-specific oxidative decarbonylation step, while in the malaria vector Anopheles gambiae, two CY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb34d47a9b68bc9c91a96f97812fe19e
https://doi.org/10.1016/j.ibmb.2019.04.018
https://doi.org/10.1016/j.ibmb.2019.04.018