Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Gareth J, Browne"'
Autor:
Alba Matas-Céspedes, Jean-Martin Lapointe, Matthew J. Elder, Gareth J. Browne, Simon J. Dovedi, Lolke de Haan, Shaun Maguire, Richard Stebbings
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionHumanized mice are emerging as valuable models to experimentally evaluate the impact of different immunotherapeutics on the human immune system. These immunodeficient mice are engrafted with human cells or tissues, that then mimic the hum
Externí odkaz:
https://doaj.org/article/11c5d1d250e84b188c37cec9021c84c8
Autor:
Carolina T. Orozco, Manuela Bersellini, Lorraine M. Irving, Wesley W. Howard, David Hargreaves, Paul W. A. Devine, Elise Siouve, Gareth J. Browne, Nicholas J. Bond, Jonathan J. Phillips, Peter Ravn, Sophie E. Jackson
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Although monoclonal antibodies have greatly improved cancer therapy, they can trigger side effects due to on-target, off-tumor toxicity. Over the past decade, strategies have emerged to successfully mask the antigen-binding site of antibodies, such t
Externí odkaz:
https://doaj.org/article/e42dd39c733d4c65b3014906af62224e
Autor:
Yariv Mazor, Robert W. Wilkinson, Daniel J. Freeman, Ikbel Achour, William Dall'Acqua, Aleksandra D. Toloczko, Thomas V. Murray, Frances Neal, Gareth J. Browne, Godfrey J. Rainey, Michelle Morrow, Asis Palazon, Yanli Wu, James Dodgson, Michael G. Overstreet, Yaya Wang, Kathy Mulgrew, Stacy Kentner, Xiaofang Jin, Arthur Lewis, Kapil Vashisht, Shelby D. Gainer, Deepa S. Subramaniam, Ben Tran, Seock-Ah Im, Bo Wang, Sumati Hasani, Des C. Jones, James Hair, Anna Hansen, Lorraine Irving, Suzanne I. Sitnikova, Chunning Yang, Matthew J. Elder, Simon J. Dovedi
Supplementary Materials and Methods, and Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238b4ab5c831dd6063dffdf564c8ad3c
https://doi.org/10.1158/2159-8290.22540037
https://doi.org/10.1158/2159-8290.22540037
Autor:
Yariv Mazor, Robert W. Wilkinson, Daniel J. Freeman, Ikbel Achour, William Dall'Acqua, Aleksandra D. Toloczko, Thomas V. Murray, Frances Neal, Gareth J. Browne, Godfrey J. Rainey, Michelle Morrow, Asis Palazon, Yanli Wu, James Dodgson, Michael G. Overstreet, Yaya Wang, Kathy Mulgrew, Stacy Kentner, Xiaofang Jin, Arthur Lewis, Kapil Vashisht, Shelby D. Gainer, Deepa S. Subramaniam, Ben Tran, Seock-Ah Im, Bo Wang, Sumati Hasani, Des C. Jones, James Hair, Anna Hansen, Lorraine Irving, Suzanne I. Sitnikova, Chunning Yang, Matthew J. Elder, Simon J. Dovedi
The clinical benefit of PD-1 blockade can be improved by combination with CTLA4 inhibition but is commensurate with significant immune-related adverse events suboptimally limiting the doses of anti-CTLA4 mAb that can be used. MEDI5752 is a monovalent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca7eaed273b219faf1bb63ec9cf8694
https://doi.org/10.1158/2159-8290.c.6549263
https://doi.org/10.1158/2159-8290.c.6549263
Autor:
Bo Wang, Frances Neal, Arthur Lewis, Kapil Vashisht, Deepa S. Subramaniam, Des C. Jones, Sumati Hasani, Daniel J. Freeman, Chunning Yang, Lorraine Irving, Michael G. Overstreet, Gareth J. Browne, Suzanne I. Sitnikova, James Hair, Robert W. Wilkinson, Yaya Wang, Ben Tran, Ikbel Achour, James Dodgson, Shelby D. Gainer, Xiaofang Jin, Seock-Ah Im, William F Dall'Acqua, Yariv Mazor, Godfrey Rainey, Asis Palazon, Anna Hansen, Yanli Wu, Matthew J. Elder, Stacy Kentner, Aleksandra D. Toloczko, Michelle Morrow, Murray Thomas Vincent, Simon J. Dovedi, Kathy Mulgrew
Publikováno v:
Cancer Discovery. 11:1100-1117
The clinical benefit of PD-1 blockade can be improved by combination with CTLA4 inhibition but is commensurate with significant immune-related adverse events suboptimally limiting the doses of anti-CTLA4 mAb that can be used. MEDI5752 is a monovalent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca36b45e55f3b372d826ed6a15c12039
https://doi.org/10.1158/2159-8290.cd-20-1445
https://doi.org/10.1158/2159-8290.cd-20-1445
Autor:
Simon J, Dovedi, Matthew J, Elder, Chunning, Yang, Suzanne I, Sitnikova, Lorraine, Irving, Anna, Hansen, James, Hair, Des C, Jones, Sumati, Hasani, Bo, Wang, Seock-Ah, Im, Ben, Tran, Deepa S, Subramaniam, Shelby D, Gainer, Kapil, Vashisht, Arthur, Lewis, Xiaofang, Jin, Stacy, Kentner, Kathy, Mulgrew, Yaya, Wang, Michael G, Overstreet, James, Dodgson, Yanli, Wu, Asis, Palazon, Michelle, Morrow, Godfrey J, Rainey, Gareth J, Browne, Frances, Neal, Thomas V, Murray, Aleksandra D, Toloczko, William, Dall'Acqua, Ikbel, Achour, Daniel J, Freeman, Robert W, Wilkinson, Yariv, Mazor
Publikováno v:
Cancer discovery. 11(5)
The clinical benefit of PD-1 blockade can be improved by combination with CTLA4 inhibition but is commensurate with significant immune-related adverse events suboptimally limiting the doses of anti-CTLA4 mAb that can be used. MEDI5752 is a monovalent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9cee0afaa71445587217670a975d51b1
https://pubmed.ncbi.nlm.nih.gov/33947716
https://pubmed.ncbi.nlm.nih.gov/33947716
Autor:
Anne-Pierre Morel, George W Hinkal, Clémence Thomas, Frédérique Fauvet, Stéphanie Courtois-Cox, Anne Wierinckx, Mojgan Devouassoux-Shisheboran, Isabelle Treilleux, Agnès Tissier, Baptiste Gras, Julie Pourchet, Isabelle Puisieux, Gareth J Browne, Douglas B Spicer, Joël Lachuer, Stéphane Ansieau, Alain Puisieux
Publikováno v:
PLoS Genetics, Vol 8, Iss 5, p e1002723 (2012)
The epithelial-mesenchymal transition (EMT) is an embryonic transdifferentiation process consisting of conversion of polarized epithelial cells to motile mesenchymal ones. EMT-inducing transcription factors are aberrantly expressed in multiple tumor
Externí odkaz:
https://doaj.org/article/cea742889eda4b7e8c8e6148940ce073
Autor:
Andrew R. Bottrill, Eva S. Jordan, Sally A. Prigent, Martin Dickens, Joanna Hay, Gareth J. Browne
Publikováno v:
Journal of Molecular Signaling; Vol 12 (2017); 3
Journal of Molecular Signaling
Journal of Molecular Signaling
Myocyte Stress Protein 1 (MS1) is a muscle-specific, stress-responsive, regulator of gene expression. It was originally identified in embryonic mouse heart which showed increased expression in a rat model of left ventricular hypertrophy. To determine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7bf3bd99245564173f6d8558aed8118
https://www.jmolecularsignaling.com/jms/article/view/1750-2187-12-3
https://www.jmolecularsignaling.com/jms/article/view/1750-2187-12-3
Autor:
Joël Lachuer, Gina Tse, Gerald Saldanha, Anne Wierinckx, Stéphane Ansieau, Peter E. Hutchinson, Eftychios Papadogeorgakis, Eugene Tulchinsky, Alain Puisieux, J.E. Osborne, Louise Hill, Julie Caramel, Geoffrey Richard, Gareth J. Browne, J. Howard Pringle
Publikováno v:
Cancer Cell. 24:466-480
SummaryAberrant expression of embryonic epithelial-mesenchymal transition-inducing transcription factors (EMT-TFs) in epithelial cells triggers EMT, neoplastic transformation, stemness, and metastatic dissemination. We found that regulation and funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c91d4e1fb45822df04cd56299deb73ba
https://doi.org/10.1016/j.ccr.2013.08.018
https://doi.org/10.1016/j.ccr.2013.08.018
Publikováno v:
Journal of Biological Chemistry. 280:18717-18727
Amino acids positively regulate signaling through the mammalian target of rapamycin (mTOR). Recent work demonstrated the importance of the tuberous sclerosis protein TSC2 for regulation of mTOR by insulin. TSC2 contains a GTPase-activator domain that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9949f27c791aa39953646ed21885eb46
https://doi.org/10.1074/jbc.m414499200
https://doi.org/10.1074/jbc.m414499200