Metformin directly suppresses atherosclerosis in normoglycaemic mice via haematopoietic adenosine monophosphate-activated protein kinase

Autor: David Carling, Dorian O. Haskard, Søren K. Moestrup, Justin C. Mason, L. Cave, Joseph J. Boyle, A. Seneviratne, Gareth Hyde

Publikováno v: Seneviratne, A, Cave, L, Hyde, G, Moestrup, S K, Carling, D, Mason, J C, Haskard, D O & Boyle, J J 2021, ' Metformin directly suppresses atherosclerosis in normoglycaemic mice via haematopoietic adenosine monophosphate-activated protein kinase ', Cardiovascular Research, vol. 117, no. 5, pp. 1295-1308 . https://doi.org/10.1093/cvr/cvaa171
Cardiovascular Research

Aims Atherosclerotic vascular disease has an inflammatory pathogenesis. Heme from intraplaque hemorrhage may drive a protective and pro-resolving macrophage M2-like phenotype, Mhem, via AMPK and ATF1. The anti-diabetic drug metformin may also activat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2da685d70a2d1fb7b288da50784ff2a
https://pure.au.dk/portal/da/publications/metformin-directly-suppresses-atherosclerosis-in-normoglycaemic-mice-via-haematopoietic-adenosine-monophosphateactivated-protein-kinase(85ce7ecf-04fc-41c3-957e-86935662d77a).html

PARP-14 combines with tristetraprolin in the selective posttranscriptional control of macrophage tissue factor expression

Autor: Kevin J. Woollard, Michael Laffan, Jun Cao, Dorian O. Haskard, Felicity N. E. Gavins, Yu Liu, Sung Hoon Cho, Gareth Hyde, Sheng Chun Yu, Andrew R. Clark, Francesco P. Marchese, M. Bilal Iqbal, Michael M. Johns, Mark Boothby, Nigel Mackman, Jonathan L.E. Dean, Perry J. Blackshear

Tissue factor (TF) (CD142) is a 47 kDa transmembrane cell surface glycoprotein that triggers the extrinsic coagulation cascade and links thrombosis with inflammation. Although macrophage TF expression is known to be regulated at the RNA level, very l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeaa84abdb1e28d47b1987ee3960a5c4
https://doi.org/10.1182/blood-2014-07-588046

A NOVEL IGG AUTOANTIBODY, LO9, REACTS SPECIFICALLY WITH ADHERENT LOW DENSITY LIPOPROTEIN (LDL), TARGETS LDL IN ATHEROSCLEROSIS IN VIVO AND STIMULATES MACROPHAGE TNFα RELEASE

Autor: Jason Johnson, Gareth Hyde, Joseph J. Boyle, Dorian O. Haskard, Chiari Kojima, Mikhail Caga-Anan, Chang Shang-Hung, Kevin J. Woollard, Oliver Gale-Grant, Ramzi Khamis, Michael M. Johns

Publikováno v: Journal of the American College of Cardiology. 67:2324

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e30cc64af72ef36908411644594aed84
https://doi.org/10.1016/s0735-1097(16)32325-7

Lineage tracing using matrilin-1 gene expression reveals that articular chondrocytes exist as the joint interzone forms

Autor: Sharon L. Dover, Attila Aszódi, Gillian A. Wallis, Raymond P. Boot-Handford, Gareth Hyde

Publikováno v: Developmental biology. 304(2)

We have developed a mouse in which the Cre recombinase gene has been targeted to exon 1 of the matrilin-1 gene (Matn1) to investigate the origins of articular chondrocytes and the development of the knee joint. Analysis of joints from offspring of Ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d63e96d51e13c6a6186be3e470ac450
https://pubmed.ncbi.nlm.nih.gov/17313942

223 A Novel Immunoglobulin G Autoantibody Against Low Density Lipoprotein (LDL) with Pathogenic Functions

Autor: Joseph J. Boyle, Ramzi Khamis, Michael M. Johns, Dorian O. Haskard, Kevin J. Woollard, Gareth Hyde, Shang-Hung Chang

Publikováno v: Heart. 100:A121.1-A121

Introduction IgG autoantibodies reacting with different forms of modified LDL are found in blood and have been associated with cardiovascular events related to atherosclerosis. However there is a controversy as to whether such antibodies are pathogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90a7041296690f618e6a6c7352a495f2
https://doi.org/10.1136/heartjnl-2014-306118.223