Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Gareth Hall"'
Autor:
Kayleigh Walker, Roberta Baravalle, Rachel Holyfield, Jacqueline Kalms, Helena Wright, Chitra Seewooruthun, Frederick W. Muskett, Anthony Scott-Tucker, Andy Merritt, Alistair Henry, Alastair D. G. Lawson, Gareth Hall, Christine Prosser, Mark D. Carr
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Interleukin-13 (IL-13) is a cytokine involved in T-cell immune responses and is a well validated therapeutic target for the treatment of asthma, along with other allergic and inflammatory diseases. IL-13 signals through a ternary signalling complex f
Externí odkaz:
https://doaj.org/article/ed60b6efb669458b96fb34943581aadf
Autor:
Georgia Bullen, Jacob D. Galson, Gareth Hall, Pedro Villar, Lien Moreels, Line Ledsgaard, Giada Mattiuzzo, Emma M. Bentley, Edward W. Masters, David Tang, Sophie Millett, Danielle Tongue, Richard Brown, Ioannis Diamantopoulos, Kothai Parthiban, Claire Tebbutt, Rachael Leah, Krishna Chaitanya, Sandra Ergueta-Carballo, Deividas Pazeraitis, Sachin B. Surade, Omodele Ashiru, Lucia Crippa, Richard Cowan, Matthew W. Bowler, Jamie I. Campbell, Wing-Yiu Jason Lee, Mark D. Carr, David Matthews, Paul Pfeffer, Simon E. Hufton, Kovilen Sawmynaden, Jane Osbourn, John McCafferty, Aneesh Karatt-Vellatt
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Passive immunization using monoclonal antibodies will play a vital role in the fight against COVID-19. The recent emergence of viral variants with reduced sensitivity to some current antibodies and vaccines highlights the importance of broad cross-re
Externí odkaz:
https://doaj.org/article/ecdc7cf013814d728091e23cf673cdda
Autor:
Richard Cowan, Caroline Bouter, Nicola Beindorff, Yvonne Bouter, Preeti Bakrania, Gareth Hall, Thomas A. Bayer, David A. Matthews, Mark D. Carr, Jemma Price, Elizabeth A. Love, Chido Mpamhanga, Sarah L. Davies
Publikováno v:
Molecular Psychiatry. 27:840-848
One of the hallmarks of Alzheimer's disease (AD) are deposits of amyloid-beta (Aβ) protein in amyloid plaques in the brain. The Aβ peptide exists in several forms, including full-length Aβ1-42 and Aβ1-40 - and the N-truncated species, pyroglutama
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2698c41a9cf2ba8b0f2737d30f8bc9fd
https://doi.org/10.1038/s41380-021-01385-7
https://doi.org/10.1038/s41380-021-01385-7
Autor:
Andrew J. Wilkinson, Nicola Ooi, Jonathan Finlayson, Victoria E. Lee, David Lyth, Kathryn S. Maskew, Rebecca Newman, David Orr, Keith Ansell, Kristian Birchall, Peter Canning, Peter Coombs, Lucia Fusani, Ed McIver, João Pisco, Philip M. Ireland, Christopher Jenkins, Isobel H. Norville, Stephanie J. Southern, Richard Cowan, Gareth Hall, Catherine Kettleborough, Victoria J. Savage, Ian R. Cooper
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 90:129331
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0647f8f8b8849a569bc3eb43aedcddae
https://doi.org/10.1016/j.bmcl.2023.129331
https://doi.org/10.1016/j.bmcl.2023.129331
Autor:
Richard Cowan, Martina Trokter, Arkadiusz Oleksy, Marina Fedorova, Kovilen Sawmynaden, Thomas Worzfeld, Stefan Offermanns, David Matthews, Mark D. Carr, Gareth Hall
Publikováno v:
Journal of Biological Chemistry. 299:104740
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b88f2b49df4104c8ae5374cbd3cf1b71
https://doi.org/10.1016/j.jbc.2023.104740
https://doi.org/10.1016/j.jbc.2023.104740
Autor:
Tara Kang-Pettinger, Kayleigh Walker, Richard Brown, Richard Cowan, Helena Wright, Roberta Baravalle, Lorna C. Waters, Frederick W. Muskett, Matthew W. Bowler, Kovilen Sawmynaden, Peter J. Coombs, Mark D. Carr, Gareth Hall
Publikováno v:
Journal of Biological Chemistry. 299:102769
Programmed death-ligand 1 (PD-L1) is a key immune regulatory protein that interacts with programmed cell death protein 1 (PD-1), leading to T-cell suppression. Whilst this interaction is key in self-tolerance, cancer cells evade the immune system by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d2423a9d75186022993ce5b2c1159c
https://doi.org/10.1016/j.jbc.2022.102769
https://doi.org/10.1016/j.jbc.2022.102769
Autor:
M. G. Gorman, Federica Coppari, N. E. Palmer, N. Bhandarkar, D. K. Bradley, Sabrina Nagel, C. Krauland, N. Masters, Laura Robin Benedetti, Shahab Khan, C. Heinbockel, Gregory Kemp, Gareth Hall, Jon Eggert, Kalpani Werellapatha, Amy Lazicki, Andrew Krygier
Publikováno v:
2021 IEEE International Conference on Plasma Science (ICOPS).
We investigate the feasibility of producing x-ray sources over timescales relevant to support time-resolved x-ray diffraction (XRDt) measurements during laser-driven dynamic compression experiments at the National Ignition Facility (NIF) [1] . XRDt p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::819d1fc1737d35cb09609ddc19f717df
https://doi.org/10.1109/icops36761.2021.9588386
https://doi.org/10.1109/icops36761.2021.9588386
Autor:
Ingrid Dreveny, Chan Li, Keith R. McCrae, Jonas Emsley, Kayleigh M. Voos, Renhao Li, Monika Pathak, Gareth Hall
Publikováno v:
Journal of Thrombosis and Haemostasis
'Journal of Thrombosis and Haemostasis ', vol: 17, pages: 759-770 (2019)
'Journal of Thrombosis and Haemostasis ', vol: 17, pages: 759-770 (2019)
Essentials Zymogen PK is activated to PKa and cleaves substrates kininogen and FXII contributing to bradykinin generation. Monomeric PKa and dimeric homologue FXI utilize the N-terminal apple domains to recruit substrates. A high-resolution 1.3 Å st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c0c038bd4f3d7a5a51f6eb1ff6680c
https://doi.org/10.1111/jth.14418
https://doi.org/10.1111/jth.14418
Autor:
Gareth Hall, Arianne Carvalhedo Reis
Publikováno v:
Bulletin of Latin American Research. 38:317-332
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e38a84fb6db5b204eb26a988df656afc
https://doi.org/10.1111/blar.12921
https://doi.org/10.1111/blar.12921
Autor:
Christopher W Holmes, Nigel J. Brunskill, Ruth C. Barber, Martin D. Tobin, Gareth Hall, Rebecca C. Allsopp, Caroline M. Cowley, Claire Blackmore, Anna Hansell, Jacqui Shaw, Philip N. Baker
Publikováno v:
SSRN Electronic Journal.
Background: Little is known about how asymptomatic testing as a method to control transmission of COVID-19 can be implemented, and the prevalence of asymptomatic infection within university populations. This study is the first to report prevalence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69095d178898b3c9175b6c69908d4845
https://doi.org/10.2139/ssrn.3945447
https://doi.org/10.2139/ssrn.3945447