Zobrazeno 1 - 10
of 209
pro vyhledávání: '"Gareth E. Jones"'
Autor:
Elizabeth Foxall, Adela Staszowska, Liisa M. Hirvonen, Mirella Georgouli, Mariacristina Ciccioli, Alexander Rimmer, Lynn Williams, Yolanda Calle, Victoria Sanz-Moreno, Susan Cox, Gareth E. Jones, Claire M. Wells
Publikováno v:
Cell Reports, Vol 31, Iss 3, Pp - (2020)
Externí odkaz:
https://doaj.org/article/e702d4baec494db8b413ecc7b47d8217
Autor:
Elizabeth Foxall, Adela Staszowska, Liisa M. Hirvonen, Mirella Georgouli, Mariacristina Ciccioli, Alexander Rimmer, Lynn Williams, Yolanda Calle, Victoria Sanz Moreno, Susan Cox, Gareth E. Jones, Claire M. Wells
Publikováno v:
Cell Reports, Vol 29, Iss 11, Pp 3385-3393.e6 (2019)
Summary: p21-Activated kinase 4 (PAK4), a serine/threonine kinase, is purported to localize to podosomes: transient adhesive structures that degrade the extracellular matrix to facilitate rapid myeloid cell migration. We find that treatment of transf
Externí odkaz:
https://doaj.org/article/51905bc0d0354906a9d3051bff7beff3
Autor:
Cheng-han Yu, Nisha Bte Mohd Rafiq, Anitha Krishnasamy, Kevin L. Hartman, Gareth E. Jones, Alexander D. Bershadsky, Michael P. Sheetz
Publikováno v:
Cell Reports, Vol 5, Iss 5, Pp 1456-1468 (2013)
Matrix-activated integrins can form different adhesion structures. We report that nontransformed fibroblasts develop podosome-like adhesions when spread on fluid Arg-Gly-Asp peptide (RGD)-lipid surfaces, whereas they habitually form focal adhesions o
Externí odkaz:
https://doaj.org/article/a0299df790664630a4d5626619be626f
Autor:
Lee Macpherson, James Monypenny, Michael P. Blundell, Giles O. Cory, Jessica Tomé-García, Adrian J. Thrasher, Gareth E. Jones, Yolanda Calle
Publikováno v:
Haematologica, Vol 97, Iss 5 (2012)
Podosomes are actin-based adhesions involved in migration of cells that have to cross tissue boundaries such as myeloid cells. The Wiskott Aldrich Syndrome Protein regulates de novo actin polymerization during podosome formation and it is cleaved by
Externí odkaz:
https://doaj.org/article/68c85b1253c1426d99668ae80767330a
Autor:
Omar M. Aboumarzouk, Rami Hasan, Ali Tasleem, Martin Mariappan, Rachael Hutton, John Fitzpatrick, Laura Beatty, Gareth E. Jones, Tarik Amer
Publikováno v:
International Brazilian Journal of Urology, Vol 43, Iss 3, Pp 394-406
ABSTRACT Background Shock wave lithotripsy (SWL) is the first line treatment modality for a significant proportion of patients with upper urinary tracts stones. Simple analgesics, opioids and non-steroidal anti-inflammatory drugs (NSAIDs) are all sui
Externí odkaz:
https://doaj.org/article/266c725e1c384fbf8f3e9867514dc089
Publikováno v:
Journal of Addiction Medicine. 16:272-277
OBJECTIVES: There is a lack of evidence exploring experiences of using e-cigarettes for smoking cessation. The study's main aim was to explore participant experiences of e-cigarettes compared to nicotine replacement therapy (NRT) delivered through st
Autor:
Wing Chung Tang, Sai Wah Tsao, Gareth E Jones, Xiong Liu, Ming Han Tsai, Henri‐Jacques Delecluse, Wei Dai, Chanping You, Jun Zhang, Shaina Chor Mei Huang, Manton Man‐hon Leung, Tengfei Liu, Yick Pang Ching, Honglin Chen, Kwok Wai Lo, Xin Li, Chi Man Tsang
Publikováno v:
Tang, W C, Tsao, S W, Jones, G E, Liu, X, Tsai, M H, Delecluse, H J, Dai, W, You, C, Zhang, J, Huang, S C M, Leung, M M H, Liu, T, Ching, Y P, Chen, H, Lo, K W, Li, X & Tsang, C M 2023, ' Latent membrane protein 1 and macrophage-derived TNFα synergistically activate and mobilize invadopodia to drive invasion of nasopharyngeal carcinoma ', Journal of pathology, vol. 259, no. 2, pp. 163-179 . https://doi.org/10.1002/path.6036
Invadopodia are actin-rich membrane protrusions that digest the matrix barrier during cancer metastasis. Since the discovery of invadopodia, they were visualized as localized and dot-like structures in different types of cancer cells on top of a 2D m
Autor:
Pamela Swiatlowska, Brian Sit, Zhen Feng, Emilie Marhuenda, Ioannis Xanthis, Simona Zingaro, Matthew Ward, Xinmiao Zhou, Qingzhong Xiao, Cathy Shanahan, Gareth E. Jones, Cheng-han Yu, Thomas Iskratsch
Publikováno v:
Science Advances. 8
Vascular smooth muscle cells (VSMCs) play a central role in the progression of atherosclerosis, where they switch from a contractile to a synthetic phenotype. Because of their role as risk factors for atherosclerosis, we sought here to systematically
Publikováno v:
Journal of Clinical Urology. 13:15-18
Aims Percutaneous nephrolithotomy is known to have a significant risk of sepsis and traditionally the systemic inflammatory response score has been used to identify post-operative patients requiring higher levels of care. Recently, the quick Sepsis R
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88251 (2014)
Podosomes are highly dynamic actin-rich adhesive structures formed predominantly by cells of the monocytic lineage, which degrade the extracellular matrix. They consist of a core of F-actin and actin-regulating proteins, surrounded by a ring of adhes
Externí odkaz:
https://doaj.org/article/41059259c11f49c6b22d13baa8fc3c38