Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Gareth E, Lim"'
Autor:
Tobias Boothe, Gareth E. Lim, Haoning Cen, Søs Skovsø, Micah Piske, Shu Nan Li, Ivan R. Nabi, Patrick Gilon, James D. Johnson
Publikováno v:
Molecular Metabolism, Vol 83, Iss , Pp 101935- (2024)
Externí odkaz:
https://doaj.org/article/8d13a52234dc4c16ac9fc7f22cbbd870
Autor:
Roderick C. Slieker, Louise A. Donnelly, Elina Akalestou, Livia Lopez-Noriega, Rana Melhem, Ayşim Güneş, Frederic Abou Azar, Alexander Efanov, Eleni Georgiadou, Hermine Muniangi-Muhitu, Mahsa Sheikh, Giuseppe N. Giordano, Mikael Åkerlund, Emma Ahlqvist, Ashfaq Ali, Karina Banasik, Søren Brunak, Marko Barovic, Gerard A. Bouland, Frédéric Burdet, Mickaël Canouil, Iulian Dragan, Petra J. M. Elders, Celine Fernandez, Andreas Festa, Hugo Fitipaldi, Phillippe Froguel, Valborg Gudmundsdottir, Vilmundur Gudnason, Mathias J. Gerl, Amber A. van der Heijden, Lori L. Jennings, Michael K. Hansen, Min Kim, Isabelle Leclerc, Christian Klose, Dmitry Kuznetsov, Dina Mansour Aly, Florence Mehl, Diana Marek, Olle Melander, Anne Niknejad, Filip Ottosson, Imre Pavo, Kevin Duffin, Samreen K. Syed, Janice L. Shaw, Over Cabrera, Timothy J. Pullen, Kai Simons, Michele Solimena, Tommi Suvitaival, Asger Wretlind, Peter Rossing, Valeriya Lyssenko, Cristina Legido Quigley, Leif Groop, Bernard Thorens, Paul W. Franks, Gareth E. Lim, Jennifer Estall, Mark Ibberson, Joline W. J. Beulens, Leen M ’t Hart, Ewan R. Pearson, Guy A. Rutter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing 2,973 individuals across three molecular classes, metabolites, lipids and proteins. Homocitrulline, isoleucine and 2-aminoadipic acid, eight triacyl
Externí odkaz:
https://doaj.org/article/8eb84b4a486246dfb262ac9be25f0911
Autor:
Yves Mugabo, Cheng Zhao, Ju Jing Tan, Anindya Ghosh, Scott A. Campbell, Evgenia Fadzeyeva, Frédéric Paré, Siew Siew Pan, Maria Galipeau, Julia Ast, Johannes Broichhagen, David J. Hodson, Erin E. Mulvihill, Sophie Petropoulos, Gareth E. Lim
Publikováno v:
JCI Insight, Vol 7, Iss 8 (2022)
While critical for neurotransmitter synthesis, 14-3-3 proteins are often assumed to have redundant functions due to their ubiquitous expression, but despite this assumption, various 14-3-3 isoforms have been implicated in regulating metabolism. We pr
Externí odkaz:
https://doaj.org/article/a212201235ad4383a3067ba2c4ddbc78
Autor:
Frederic Abou Azar, Gareth E. Lim
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The canonical Wnt signaling pathway is ubiquitous throughout the body and influences a diverse array of physiological processes. Following the initial discovery of the Wnt signaling pathway during wing development in Drosophila melanogaster, it is no
Externí odkaz:
https://doaj.org/article/4b908b682e304d758635039efcfe134e
Autor:
Kadidia Diallo, Sylvie Dussault, Christophe Noll, Angel F. Lopez, Alain Rivard, André C. Carpentier, Gareth E. Lim
Publikováno v:
Molecular Metabolism, Vol 41, Iss , Pp 101052- (2020)
Objective: Adaptive thermogenesis, which is partly mediated by sympathetic input on brown adipose tissue (BAT), is a mechanism of heat production that confers protection against prolonged cold exposure. Various endogenous stimuli, for example, norepi
Externí odkaz:
https://doaj.org/article/cbb61bedabbe455ba3b0501e1ff26d2b
Autor:
Nicole M. Templeman, Stephane Flibotte, Jenny H.L. Chik, Sunita Sinha, Gareth E. Lim, Leonard J. Foster, Corey Nislow, James D. Johnson
Publikováno v:
Cell Reports, Vol 20, Iss 2, Pp 451-463 (2017)
The causal relationships between insulin levels, insulin resistance, and longevity are not fully elucidated. Genetic downregulation of insulin/insulin-like growth factor 1 (Igf1) signaling components can extend invertebrate and mammalian lifespan, bu
Externí odkaz:
https://doaj.org/article/062c00d4b880412c8310ec0f73b55e48
Autor:
Tobias Boothe, Gareth E. Lim, Haoning Cen, Søs Skovsø, Micah Piske, Shu Nan Li, Ivan R. Nabi, Patrick Gilon, James D. Johnson
Publikováno v:
Molecular Metabolism, Vol 5, Iss 5, Pp 366-378 (2016)
Objective: The role and mechanisms of insulin receptor internalization remain incompletely understood. Previous trafficking studies of insulin receptors involved fluorescent protein tagging at their termini, manipulations that may be expected to resu
Externí odkaz:
https://doaj.org/article/508ffe3ef0674c3d8403ed3f3e2e81d3
Autor:
SABRI A. RIAL, AMAL ALKHOURY, GENEVIEVE LAVOIE, PHILIPPE ROUX, THOMAS M. DURCAN, AIDA MARTINEZ-SANCHEZ, GARETH E. LIM
Publikováno v:
Diabetes. 71
Aim: We previously discovered that 14-3-3-zeta (14-3-3ζ) was essential for adipocyte differentiation. Although 14-3-3ζ scaffold is not a transcription factor (TF) , it undergoes nuclear translocation during adipogenesis. Considering its diverse int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be37ed6b352704ff838da3ed5d8c76be
https://doi.org/10.2337/db22-1396-p
https://doi.org/10.2337/db22-1396-p
Autor:
Siyi He, Gareth E. Lim
Publikováno v:
Advanced Biology. 7:2200151
During the past decades, unprecedented progress in technologies has revolutionized traditional research methodologies. Among these, advances in high-throughput drug screening approaches have permitted the rapid identification of potential therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96980e8a91b4205baf6e7174f6293be5
https://doi.org/10.1002/adbi.202200151
https://doi.org/10.1002/adbi.202200151
Publikováno v:
Pharmacological Research. 139:199-206
Since their initial characterization as abundant brain proteins more than 5 decades ago, a resurgence into understanding the cellular functions of 14-3-3 proteins has emerged. While one of the earliest functions attributed to this eukaryotic scaffold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d47199613bf9346f4a3dc2a752243aee
https://doi.org/10.1016/j.phrs.2018.11.021
https://doi.org/10.1016/j.phrs.2018.11.021