Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Gareth D Fenn"'
Publikováno v:
Acta Crystallographica. Section F, Structural Biology Communications
A 1.47 Å resolution crystal structure of human inositol monophosphatase bound to the inhibitor ebselen is presented. In the structure, ebselen forms a selenosulfide bond to Cys141 and ebselen-mediated contacts between two dimers give a tetramer with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876bc2bbd358c03443c35c6b3e1da589
http://europepmc.org/articles/PMC7531247
http://europepmc.org/articles/PMC7531247
Publikováno v:
Molecular Genetics and Metabolism. 138:107098
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50b2ceb1a1a448d8f2263a6ad2489625
https://doi.org/10.1016/j.ymgme.2022.107098
https://doi.org/10.1016/j.ymgme.2022.107098
Publikováno v:
Molecular Genetics and Metabolism. 138:107097
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d607a7b8adaf3f709643a677daf7f9c
https://doi.org/10.1016/j.ymgme.2022.107097
https://doi.org/10.1016/j.ymgme.2022.107097
Inositol monophosphatase (IMPase) is inhibited by lithium, the most efficacious treatment for bipolar disorder. Several therapies have been approved, or are going through clinical trials, aimed at the replacement of lithium in the treatment of bipola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd395b58c40d33473bceae5140b2b4a
https://orca.cardiff.ac.uk/id/eprint/134752/3/uf5002.pdf
https://orca.cardiff.ac.uk/id/eprint/134752/3/uf5002.pdf
Autor:
Cerys Bladen, Emyr Lloyd-Evans, Helen Waller-Evans, Kim Wager, Jordan Copner, Emily Maguire, Gareth D Fenn, Johanna Smith, Sophie R Cook
Publikováno v:
Histochemistry and Cell Biology
Lysosomal storage diseases are the most common cause of neurodegeneration in children. They are characterised at the cellular level by the accumulation of storage material within lysosomes. There are very limited therapeutic options, and the search f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e6f4873d7be395f607dcc45d9794976
https://pubmed.ncbi.nlm.nih.gov/33079236
https://pubmed.ncbi.nlm.nih.gov/33079236