Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Gareth A. Palidwor"'
Autor:
Ali Karimnezhad, Gareth A. Palidwor, Kednapa Thavorn, David J. Stewart, Pearl A. Campbell, Bryan Lo, Theodore J. Perkins
Publikováno v:
BMC Medical Genomics, Vol 13, Iss 1, Pp 1-14 (2020)
Abstract Background Treating cancer depends in part on identifying the mutations driving each patient’s disease. Many clinical laboratories are adopting high-throughput sequencing for assaying patients’ tumours, applying targeted panels to formal
Externí odkaz:
https://doaj.org/article/6bfb6a896b2a4e2d9bc12e5eaa2a565c
Autor:
Ludivine Coudière Morrison, Jennifer A. Chan, Margaret Stromecki, Gareth A. Palidwor, Maria C. Vladoiu, Cynthia Hawkins, Jamie Zagozewski, Tamra E. Werbowetski-Ogilvie, Ghazaleh M. Shahriary, Janilyn Arsenio, Olivier Ayrault, Lakshmikirupa Sundaresan, Vijay Ramaswamy, Antoine Forget, Agnes Fresnoza, Christopher J. Porter, Michael D. Taylor, Olivier Saulnier
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.3627. ⟨10.1038/s41467-020-17357-4⟩
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications, 2020, 11 (1), pp.3627. ⟨10.1038/s41467-020-17357-4⟩
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.3627. ⟨10.1038/s41467-020-17357-4⟩
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications, 2020, 11 (1), pp.3627. ⟨10.1038/s41467-020-17357-4⟩
OTX2 is a potent oncogene that promotes tumor growth in Group 3 medulloblastoma. However, the mechanisms by which OTX2 represses neural differentiation are not well characterized. Here, we perform extensive multiomic analyses to identify an OTX2 regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459b190d3ef9954563e763e01f7f9b7e
https://www.hal.inserm.fr/inserm-02946666/document
https://www.hal.inserm.fr/inserm-02946666/document
Autor:
Theodore J. Perkins, Hang Yin, Michael A. Rudnicki, Christopher J. Porter, Duy Nguyen, Parameswaran Ramachandran, Gareth A. Palidwor, Vahab D. Soleimani
Publikováno v:
Nucleic Acids Research
Muscle-specific transcription factor MyoD orchestrates the myogenic gene expression program by binding to short DNA motifs called E-boxes within myogenic cis-regulatory elements (CREs). Genome-wide analyses of MyoD cistrome by chromatin immnunoprecip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643d969fffd55d90bebaefb14dede1dd
https://doi.org/10.1093/nar/gky388
https://doi.org/10.1093/nar/gky388
Autor:
Emma Bondy-Chorney, Jocelyn Côté, Francesca A. Barry, Janice Robertson, Alexandre Savard, Julia Keith, Lorne Zinman, Véronique Tremblay, John Woulfe, Maneka Chitiprolu, Jean-François Couture, Mathieu Lavallée-Adam, Chantal Jagow, Gareth A. Palidwor, Ekaterina Rogaeva, Geneviève Paris, Derrick Gibbings
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Nature Communications
Nature Communications
Mutations in proteins like FUS which cause Amyotrophic Lateral Sclerosis (ALS) result in the aberrant formation of stress granules while ALS-linked mutations in other proteins impede elimination of stress granules. Repeat expansions in C9ORF72, the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96179302945c215a9d7a6e5ada31a7e
https://doaj.org/article/bbf18a982cd84beb955aa489eecafe37
https://doaj.org/article/bbf18a982cd84beb955aa489eecafe37
Autor:
Gareth A Palidwor, Sergey Shcherbinin, Matthew R Huska, Tamas Rasko, Ulrich Stelzl, Anup Arumughan, Raphaele Foulle, Pablo Porras, Luis Sanchez-Pulido, Erich E Wanker, Miguel A Andrade-Navarro
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 3, p e1000304 (2009)
A growing number of solved protein structures display an elongated structural domain, denoted here as alpha-rod, composed of stacked pairs of anti-parallel alpha-helices. Alpha-rods are flexible and expose a large surface, which makes them suitable f
Externí odkaz:
https://doaj.org/article/e5001745c12f4778a1e58afef071e9d0
Autor:
Sarah Y. Kwon, F. Jeffrey Dilworth, Theodore J. Perkins, Hilmar Strickfaden, James Ellis, Carole Doré, Wing Y. Chang, William L. Stanford, Rita A. Kandel, Alton Etheridge, Gareth A. Palidwor, Zhigang Jin, Michael J. Hendzel, Ji-Hoon Cho, Akitsu Hotta, Zhaoyi Chen, Angela Raymond, Kai Wang, David J. Galas
Publikováno v:
Aging Cell
Summary Ideally, disease modeling using patient‐derived induced pluripotent stem cells (iPSCs) enables analysis of disease initiation and progression. This requires any pathological features of the patient cells used for reprogramming to be elimina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09c59ce1db67513cfcf5a1fc0c8b62bc
https://doi.org/10.1111/acel.12621
https://doi.org/10.1111/acel.12621
Autor:
Bryan Lo, Ali Karimnezhad, Kednapa Thavorn, Pearl A. Campbell, David J. Stewart, Gareth A. Palidwor, Theodore J. Perkins
Publikováno v:
BMC Medical Genomics
BMC Medical Genomics, Vol 13, Iss 1, Pp 1-14 (2020)
BMC Medical Genomics, Vol 13, Iss 1, Pp 1-14 (2020)
Background Treating cancer depends in part on identifying the mutations driving each patient’s disease. Many clinical laboratories are adopting high-throughput sequencing for assaying patients’ tumours, applying targeted panels to formalin-fixed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94666b5b2a5eb07fbbeed8fa60b4161e
https://doi.org/10.1101/2019.12.31.891952
https://doi.org/10.1101/2019.12.31.891952
Autor:
Ludivine Coudière Morrison, Jamie Zagozewski, Gareth A. Palidwor, Tamra E. Werbowetski-Ogilvie, Vijay Ramaswamy, Margaret Stromecki
Medulloblastoma (MB) is the most common malignant primary pediatric brain tumor. Of the four distinct molecular MB subgroups, Group 3 MB has the worst prognosis, is highly metastatic, and is poorly defined with regard to the pathways that contribute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32628321bacdf19bcff554a0bf4912d
https://europepmc.org/articles/PMC6217684/
https://europepmc.org/articles/PMC6217684/
Autor:
Hannah L. Battaion, Hani Jrade, Christopher Cafariello, Christopher J. Porter, Harinad B. Maganti, Safwat T. Khan, Caryn Ito, Janet L. Manias Rothberg, Robert F. Paulson, William L. Stanford, Gareth A. Palidwor, Theodore J. Perkins
Publikováno v:
Cell Discovery
Polycomb repressive complex 2 (PRC2) accessory proteins play substoichiometric, tissue-specific roles to recruit PRC2 to specific genomic loci or increase enzymatic activity, while PRC2 core proteins are required for complex stability and global leve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb65c17d415cc1310e2b7e21e0276dae
http://europepmc.org/articles/PMC5928144
http://europepmc.org/articles/PMC5928144
Autor:
Tamra E. Werbowetski-Ogilvie, Marc R. Del Bigio, Till Milde, Michael D. Taylor, Vijay Ramaswamy, Ravinder Kaur, Jamie Zagozewski, Gareth A. Palidwor, Margaret Stromecki, Matthias Wölfl, Ludivine Coudière Morrison, Patryk Skowron, Nazanin Tatari
Publikováno v:
Molecular Oncology
Molecular Oncology, Vol 12, Iss 4, Pp 495-513 (2018)
Molecular Oncology, Vol 12, Iss 4, Pp 495-513 (2018)
Medulloblastoma (MB) is the most common malignant primary pediatric brain cancer. Among the most aggressive subtypes, Group 3 and Group 4 originate from stem/progenitor cells, frequently metastasize, and often display the worst prognosis, yet we know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b15fa34f2e65dca94bb8aea53172e2
https://pubmed.ncbi.nlm.nih.gov/29377567
https://pubmed.ncbi.nlm.nih.gov/29377567