Eukarion-134 Attenuates Endoplasmic Reticulum Stress-Induced Mitochondrial Dysfunction in Human Skeletal Muscle Cells

Autor: Anastasia Thoma, Max Lyon, Nasser Al-Shanti, Gareth A. Nye, Robert G. Cooper, Adam P. Lightfoot

Publikováno v: Antioxidants, Vol 9, Iss 8, p 710 (2020)

Maladaptive endoplasmic reticulum (ER) stress is associated with modified reactive oxygen species (ROS) generation and mitochondrial abnormalities; and is postulated as a potential mechanism involved in muscle weakness in myositis, an acquired autoim

Externí odkaz: https://doaj.org/article/627398d571bb41258e38a316a98df8a8

A massively multi-scale approach to characterising tissue architecture by synchrotron micro-CT applied to the human placenta

Autor: Michele C. Darrow, Oliver N. King, Igor L. Chernyavsky, Edward D. Johnstone, Yasuaki Tokudome, Gowsihan Poologasundarampillai, William M Tun, Helen Bischof, Paul Brownbill, Rohan M. Lewis, Gareth A. Nye, Mark Basham

Publikováno v: Journal of the Royal Society Interface

Multi-scale structural assessment of biological soft tissue is challenging but essential to gain insight into structure-function relationships of tissue/organ. Using the human placenta as an example, this study brings together sophisticated sample pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e556571cf96480c8d40d80d34b4e90
https://doi.org/10.1101/2020.12.07.411462

Quantifying the impact of tissue metabolism on solute transport in feto-placental microvascular networks

Autor: Alexander Erlich, Igor L. Chernyavsky, Paul Brownbill, Gareth A. Nye, Oliver E. Jensen

Publikováno v: Interface Focus
Erlich, A, Nye, G A, Brownbill, P, Jensen, O E & Chernyavsky, I L 2019, ' Quantifying the impact of tissue metabolism on solute transport in feto-placental microvascular networks ', Interface Focus . https://doi.org/10.1098/rsfs.2019.0021

The primary exchange units in the human placenta are terminal villi, in which fetal capillary networks are surrounded by a thin layer of villous tissue, separating fetal from maternal blood. To understand how the complex spatial structure of villi in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227cbf8bf1ebdb924c418f058bd82465
https://pubmed.ncbi.nlm.nih.gov/31485311

IFPA meeting 2017 workshop report: Clinical placentology, 3D structure-based modeling of placental function, placental bed, and treating placental dysfunction

Autor: Lawrence W. Chamley, David Elad, Henning Schneider, Ganesh Acharya, John D. Aplin, Lopa Leach, Gareth A. Nye, Rohan M. Lewis, Alys R. Clark, Terry K. Morgan, Carolyn Salafia, Alexander E. P. Heazell, Oliver E. Jensen, Jenny Myers, Judith N. Bulmer, Marcel Filoche, Edward D. Johnstone, Igor L. Chernyavsky, Graham J. Burton, Paul Brownbill, Sally Collins, Natalie J. Hannan, Perrie O'Tierney-Ginn, Mark Dilworth, Michelle L. Oyen, Elizabeth Cottrell

Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 2017 there were four themed workshops, all of which are summarized in this report. These workshops discussed new knowledge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeba68d5916dfae6b2b66d8e06b54053

SS-31 attenuates TNF-α induced cytokine release from C2C12 myotubes

Autor: Anne McArdle, Adam P. Lightfoot, Francis McArdle, Giorgos K. Sakellariou, Richard D. Griffiths, Malcolm J. Jackson, Gareth A. Nye

Publikováno v: Redox Biology

TNF-α is a key inflammatory mediator and is proposed to induce transcriptional responses via the mitochondrial generation of Reactive Oxygen Species (ROS). The aim of this study was to determine the effect of TNF-α on the production of myokines by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b31f178ec2c6d839acb2175240b3da
http://europepmc.org/articles/PMC4556772