Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus.

Autor: Christopher G Bell, Sarah Finer, Cecilia M Lindgren, Gareth A Wilson, Vardhman K Rakyan, Andrew E Teschendorff, Pelin Akan, Elia Stupka, Thomas A Down, Inga Prokopenko, Ian M Morison, Jonathan Mill, Ruth Pidsley, International Type 2 Diabetes 1q Consortium, Panos Deloukas, Timothy M Frayling, Andrew T Hattersley, Mark I McCarthy, Stephan Beck, Graham A Hitman

Publikováno v: PLoS ONE, Vol 5, Iss 11, p e14040 (2010)

Recent multi-dimensional approaches to the study of complex disease have revealed powerful insights into how genetic and epigenetic factors may underlie their aetiopathogenesis. We examined genotype-epigenotype interactions in the context of Type 2 D

Externí odkaz: https://doaj.org/article/4d81a664453744d2912ef928bbd7afd7

Supplementary Table S3 from Tracking the Genomic Evolution of Esophageal Adenocarcinoma through Neoadjuvant Chemotherapy

Autor: Charles Swanton, George B. Hanna, Daniel Hochhauser, Nik Matthews, Sharmin Begum, Jennifer Biggs, Benjamin Phillimore, Andrew Rowan, Stuart Horswell, Richard Mitter, Max Salm, Nima Abbassi-Ghadi, Sacheen Kumar, Nicholas McGranahan, Thomas B.K. Watkins, Nicolai J. Birkbak, Gareth A. Wilson, Nirupa Murugaesu

Detailed information of candidate driver mutations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e05f8ab74581e5899ecc3038c9ab6a01
https://doi.org/10.1158/2159-8290.22531584

Data from CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma

Autor: John D. Kelly, Asif Muneer, Tyson V. Sharp, Tim Fenton, Stephan Beck, Tom Powles, Gareth A. Wilson, Charles Jameson, Alex Freeman, Simon Rodney, Wei Shen Tan, Peter R. Malone, Raj Nigam, Muhammad Saqib, Manit Arya, Kunal Shah, Patricia de Winter, Ankur Chakravarthy, Daniel C. Worth, Andrew Feber

Other than an association with HPV infection, little is known about the genetic alterations determining the development of penile cancer. Although penile cancer is rare in the developed world, it presents a significant burden in developing countries.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::216f52586a881f6887a26d4372aad33a
https://doi.org/10.1158/0008-5472.c.6508209.v1

Supplementary Table 1 and Supplementary Figures 1 through 6 from CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma

Autor: John D. Kelly, Asif Muneer, Tyson V. Sharp, Tim Fenton, Stephan Beck, Tom Powles, Gareth A. Wilson, Charles Jameson, Alex Freeman, Simon Rodney, Wei Shen Tan, Peter R. Malone, Raj Nigam, Muhammad Saqib, Manit Arya, Kunal Shah, Patricia de Winter, Ankur Chakravarthy, Daniel C. Worth, Andrew Feber

Supplementary Table 1. A)Patient details for Fresh Frozen test cohort, B) Patient details for validation cohort. Supplementary Figure 1. APOBEC mutation fraction of across multiple cancer types. Supplementary Figure 2. DNA methylation. Supplementary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699ead6d2c936e199f3310310b0271a9
https://doi.org/10.1158/0008-5472.22411374

Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse

Autor: Saba Ferdous, Charles Swanton, Francesca Chemi, Chang Sik Kim, Selvaraju Veeriah, Ged Brady, Sakshi Gulati, Deborah J. Burt, Mariam Jamal-Hanjani, Fiona H Blackhall, Daniel Slane-Tan, Nicholas McGranahan, Jackie Pierce, Marek Dynowski, Crispin J. Miller, Barbara Mesquita, Dominic G. Rothwell, Cong Zhou, David Allan Moore, Simon P. Pearce, Fabio Gomes, Philip A.J. Crosbie, Jonathan Tugwood, Nicolai Juul Birkbak, R. Shah, Gareth A. Wilson, Christopher Abbosh, Sophia Ward, Maise Al Bakir, Allan Hackshaw, Crispin T. Hiley, Caroline Dive, Dhruva Biswas, Yvonne Summers

Publikováno v: Chemi, F, Rothwell, D G, McGranahan, N, Gulati, S, Abbosh, C, Pearce, S P, Zhou, C, Wilson, G A, Jamal-Hanjani, M, Birkbak, N, Pierce, J, Kim, C S, Ferdous, S, Burt, D J, Slane-Tan, D, Gomes, F, Moore, D, Shah, R, Al Bakir, M, Hiley, C, Veeriah, S, Summers, Y, Crosbie, P, Ward, S, Mesquita, B, Dynowski, M, Biswas, D, Tugwood, J, Blackhall, F, Miller, C, Hackshaw, A, Brady, G, Swanton, C, Dive, C & TRACERx Consortium 2019, ' Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse ', Nature Medicine, vol. 25, no. 10, pp. 1534-1539 . https://doi.org/10.1038/s41591-019-0593-1
TRACERx Consortium 2019, ' Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse ', Nature Medicine, vol. 25, no. 10, pp. 1534-1539 . https://doi.org/10.1038/s41591-019-0593-1

Approximately 50% of patients with early-stage non-small-cell lung cancer (NSCLC) who undergo surgery with curative intent will relapse within 5 years1,2. Detection of circulating tumor cells (CTCs) at the time of surgery may represent a tool to iden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d6ddd0b6c3e7f59bde65bfbe961685
https://doi.org/10.1038/s41591-019-0593-1