Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Garegin A, Papoian"'
Autor:
Haiqing Zhao, Hao Wu, Alex Guseman, Dulith Abeykoon, Christina M Camara, Yamini Dalal, David Fushman, Garegin A Papoian
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 1, p e1011721 (2024)
Histones compact and store DNA in both Eukarya and Archaea, forming heterodimers in Eukarya and homodimers in Archaea. Despite this, the folding mechanism of histones across species remains unclear. Our study addresses this gap by investigating 11 ty
Externí odkaz:
https://doaj.org/article/911e2e3354f440d1907297889510cd1f
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Stress fibers are actomyosin bundles that regulate cellular mechanosensation and force transduction. Interacting with the extracellular matrix through focal adhesion complexes, stress fibers are highly dynamic structures regulated by myosin
Externí odkaz:
https://doaj.org/article/aa75a1f7baee4b748defd3d9029c65a4
Autor:
Qin Ni, Kaustubh Wagh, Aashli Pathni, Haoran Ni, Vishavdeep Vashisht, Arpita Upadhyaya, Garegin A Papoian
Publikováno v:
eLife, Vol 11 (2022)
In most eukaryotic cells, actin filaments assemble into a shell-like actin cortex under the plasma membrane, controlling cellular morphology, mechanics, and signaling. The actin cortex is highly polymorphic, adopting diverse forms such as the ring-li
Externí odkaz:
https://doaj.org/article/545608be2de84536ba0c939a1640cd5f
Autor:
Maria-Veronica Ciocanel, Aravind Chandrasekaran, Carli Mager, Qin Ni, Garegin A Papoian, Adriana Dawes
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 4, p e1010026 (2022)
Cortical actin networks are highly dynamic and play critical roles in shaping the mechanical properties of cells. The actin cytoskeleton undergoes significant reorganization in many different contexts, including during directed cell migration and ove
Externí odkaz:
https://doaj.org/article/5ce4f0f8050a4b25b01a945d41e4f846
Autor:
Xiaona Li, Qin Ni, Xiuxiu He, Jun Kong, Soon-Mi Lim, Garegin A Papoian, Jerome P Trzeciakowski, Andreea Trache, Yi Jiang
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 6, p e1007693 (2020)
Understanding cellular remodeling in response to mechanical stimuli is a critical step in elucidating mechanical activation of biochemical signaling pathways. Experimental evidence indicates that external stress-induced subcellular adaptation is acco
Externí odkaz:
https://doaj.org/article/925214784ef44ba496c305d032eba865
Autor:
Minh Bui, Mary Pitman, Arthur Nuccio, Serene Roque, Paul Gregory Donlin-Asp, Aleksandra Nita-Lazar, Garegin A. Papoian, Yamini Dalal
Publikováno v:
Epigenetics & Chromatin, Vol 10, Iss 1, Pp 1-21 (2017)
Abstract Background Posttranslational modifications of core histones are correlated with changes in transcriptional status, chromatin fiber folding, and nucleosome dynamics. However, within the centromere-specific histone H3 variant CENP-A, few modif
Externí odkaz:
https://doaj.org/article/1da0f65eaf224c009ca633fd23deaf2f
Theoretical and computational validation of the Kuhn barrier friction mechanism in unfolded proteins
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract A long time ago, Kuhn predicted that long polymers should approach a limit where their global motion is controlled by solvent friction alone, with ruggedness of their energy landscapes having no consequences for their dynamics. In contrast,
Externí odkaz:
https://doaj.org/article/f3a3e22f75774b28b052c2e346b47321
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 7, p e1007156 (2019)
Bundled actin structures play a key role in maintaining cellular shape, in aiding force transmission to and from extracellular substrates, and in affecting cellular motility. Recent studies have also brought to light new details on stress generation,
Externí odkaz:
https://doaj.org/article/cbb9b310f1884486a25b6afe8bd11a78
Publikováno v:
Scientific Reports. 13
Stress fibers are actomyosin bundles that regulate cellular mechanosensation and force transduction. Interacting with the extracellular matrix through focal adhesion complexes, stress fibers are highly dynamic structures regulated by myosin motors an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ea5e813920cf0c2a3b7ba5c8adc518e
https://doi.org/10.1038/s41598-023-35675-7
https://doi.org/10.1038/s41598-023-35675-7
Autor:
Haiqing Zhao, Hao Wu, Alex Guseman, Dulith Abeykoon, Christina M. Camara, Yamini Dalal, David Fushman, Garegin A. Papoian
Histones are the dominant proteins to compact and store DNA in both Eukarya and Archaea. For a long time, histones are observed to exist in the unit of dimers but diverge into different formats such as heterodimers in Eukarya or homodimers in Archaea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c7cfccafb252ed49f404953da1f2413
https://doi.org/10.1101/2022.10.15.512373
https://doi.org/10.1101/2022.10.15.512373
