Polymer-Supported Tetrafluorophenol:  A New Activated Resin for Chemical Library Synthesis

Autor: Salvino, J. M., Kumar, N. V., Orton, E., Airey, J., Kiesow, T., Crawford, K., Mathew, R., Krolikowski, P., Drew, M., Engers, D., Krolikowski, D., Herpin, T., Gardyan, M., McGeehan, G., Labaudiniere, R.

Publikováno v: Journal of Combinatorial Chemistry; November 2000, Vol. 2 Issue: 6 p691-697, 7p

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Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma.

Autor: Harrison BA; Department of Medicinal Chemistry, Lexicon Pharmaceuticals , 350 Carter Road, Princeton, New Jersey 08540, United States., Almstead ZY; Department of Medicinal Chemistry, Lexicon Pharmaceuticals , 350 Carter Road, Princeton, New Jersey 08540, United States., Burgoon H; Department of Medicinal Chemistry, Lexicon Pharmaceuticals , 350 Carter Road, Princeton, New Jersey 08540, United States., Gardyan M; Department of Medicinal Chemistry, Lexicon Pharmaceuticals , 350 Carter Road, Princeton, New Jersey 08540, United States., Goodwin NC; Department of Medicinal Chemistry, Lexicon Pharmaceuticals , 350 Carter Road, Princeton, New Jersey 08540, United States., Healy J; Department of Medicinal Chemistry, Lexicon Pharmaceuticals , 350 Carter Road, Princeton, New Jersey 08540, United States., Liu Y; Department of Medicinal Chemistry, Lexicon Pharmaceuticals , 350 Carter Road, Princeton, New Jersey 08540, United States., Mabon R; Department of Medicinal Chemistry, Lexicon Pharmaceuticals , 350 Carter Road, Princeton, New Jersey 08540, United States., Marinelli B; Department of Medicinal Chemistry, Lexicon Pharmaceuticals , 350 Carter Road, Princeton, New Jersey 08540, United States., Samala L; Department of Medicinal Chemistry, Lexicon Pharmaceuticals , 350 Carter Road, Princeton, New Jersey 08540, United States., Zhang Y; Department of Medicinal Chemistry, Lexicon Pharmaceuticals , 350 Carter Road, Princeton, New Jersey 08540, United States., Stouch TR; Department of Medicinal Chemistry, Lexicon Pharmaceuticals , 350 Carter Road, Princeton, New Jersey 08540, United States., Whitlock NA; Department of Pharmaceutical Discovery, Department of Drug Metabolism, Pharmacokinetics, and Toxicology and Department of Ophthalmology, Lexicon Pharmaceuticals , 8800 Technology Forest Place, The Woodlands, Texas 77381, United States., Gopinathan S; Department of Pharmaceutical Discovery, Department of Drug Metabolism, Pharmacokinetics, and Toxicology and Department of Ophthalmology, Lexicon Pharmaceuticals , 8800 Technology Forest Place, The Woodlands, Texas 77381, United States., McKnight B; Department of Pharmaceutical Discovery, Department of Drug Metabolism, Pharmacokinetics, and Toxicology and Department of Ophthalmology, Lexicon Pharmaceuticals , 8800 Technology Forest Place, The Woodlands, Texas 77381, United States., Wang S; Department of Pharmaceutical Discovery, Department of Drug Metabolism, Pharmacokinetics, and Toxicology and Department of Ophthalmology, Lexicon Pharmaceuticals , 8800 Technology Forest Place, The Woodlands, Texas 77381, United States., Patel N; Department of Pharmaceutical Discovery, Department of Drug Metabolism, Pharmacokinetics, and Toxicology and Department of Ophthalmology, Lexicon Pharmaceuticals , 8800 Technology Forest Place, The Woodlands, Texas 77381, United States., Wilson AG; Department of Pharmaceutical Discovery, Department of Drug Metabolism, Pharmacokinetics, and Toxicology and Department of Ophthalmology, Lexicon Pharmaceuticals , 8800 Technology Forest Place, The Woodlands, Texas 77381, United States., Hamman BD; Department of Pharmaceutical Discovery, Department of Drug Metabolism, Pharmacokinetics, and Toxicology and Department of Ophthalmology, Lexicon Pharmaceuticals , 8800 Technology Forest Place, The Woodlands, Texas 77381, United States., Rice DS; Department of Pharmaceutical Discovery, Department of Drug Metabolism, Pharmacokinetics, and Toxicology and Department of Ophthalmology, Lexicon Pharmaceuticals , 8800 Technology Forest Place, The Woodlands, Texas 77381, United States., Rawlins DB; Department of Medicinal Chemistry, Lexicon Pharmaceuticals , 350 Carter Road, Princeton, New Jersey 08540, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2014 Nov 24; Vol. 6 (1), pp. 84-8. Date of Electronic Publication: 2014 Nov 24 (Print Publication: 2015).