E2F1-induced autocrine IL-6 inflammatory loop mediates cancer-immune crosstalk that predicts T cell phenotype switching and therapeutic responsiveness.

Autor: Spitschak A; Institute of Experimental Gene Therapy and Cancer Research, Rostock University Medical Center, Rostock, Germany., Dhar P; Institute of Experimental Gene Therapy and Cancer Research, Rostock University Medical Center, Rostock, Germany., Singh KP; Department of Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany., Garduño RC; Institute of Experimental Gene Therapy and Cancer Research, Rostock University Medical Center, Rostock, Germany., Gupta SK; Department of Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany.; Department of Biomedical Engineering & Bioinformatics, Chhattisgarh Swami Vivekananda Technical University, Bhilai, Chhattisgarh, India., Vera J; Laboratory of Systems Tumor Immunology, Department of Dermatology, Uniklinikum Erlangen and Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Erlangen, Germany., Musella L; Laboratory of Systems Tumor Immunology, Department of Dermatology, Uniklinikum Erlangen and Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Erlangen, Germany., Murr N; Institute of Experimental Gene Therapy and Cancer Research, Rostock University Medical Center, Rostock, Germany., Stoll A; Institute of Experimental Gene Therapy and Cancer Research, Rostock University Medical Center, Rostock, Germany., Pützer BM; Institute of Experimental Gene Therapy and Cancer Research, Rostock University Medical Center, Rostock, Germany.; Department Life, Light & Matter, University of Rostock, Rostock, Germany.

Publikováno v: Frontiers in immunology [Front Immunol] 2024 Oct 31; Vol. 15, pp. 1470368. Date of Electronic Publication: 2024 Oct 31 (Print Publication: 2024).