GSK3 inhibition rescues growth and telomere dysfunction in dyskeratosis congenita iPSC-derived type II alveolar epithelial cells.

Autor: Fernandez RJ; Medical Scientist Training Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.; Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States., Gardner ZJG; Medical Scientist Training Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.; Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States., Slovik KJ; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, United States., Liberti DC; Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States., Estep KN; Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States., Yang W; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, United States.; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States., Chen Q; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States., Santini GT; Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States., Perez JV; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States., Root S; College of Arts and Sciences and Vagelos Scholars Program, University of Pennsylvania, Philadelphia, United States., Bhatia R; Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States., Tobias JW; Penn Genomic Analysis Core, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States., Babu A; Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, United States.; Penn-CHOP Lung Biology Institute, University of Pennsylvania, Philadelphia, United States., Morley MP; Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, United States.; Penn-CHOP Lung Biology Institute, University of Pennsylvania, Philadelphia, United States., Frank DB; Penn-CHOP Lung Biology Institute, University of Pennsylvania, Philadelphia, United States.; Division of Pediatric Cardiology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, United States., Morrisey EE; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, United States.; Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, United States.; Penn-CHOP Lung Biology Institute, University of Pennsylvania, Philadelphia, United States., Lengner CJ; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, United States.; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, United States., Johnson FB; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, United States.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.; Institute on Aging, University of Pennsylvania, Philadelphia, United States.

Publikováno v: ELife [Elife] 2022 May 13; Vol. 11. Date of Electronic Publication: 2022 May 13.