Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Gardner, Charles J."'
Autor:
David Stefany, Ali Ardati, Harris Keith John, Aguiar Joacy C, Roy J. Vaz, Ashfaq Parkar, Lim Sungtaek, Yi Li, Tim Gillespy, Gardner Charles J, Lan Mu, Robert Marcus, Cao Bin, Isabelle Morize, Dragan A. Cirovic
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:66-75
A Comparative Molecular Similarity Indices Analysis (CoMSIA) was performed for 2,6-substituted-4-monosubstituted aminopyrimidine antagonists of prostaglandin D(2) receptor (DP). Both two-component (Q(2) = 0.63, R(2) = 0.82, SEE = 0.47 pIC(50)) and th
Autor:
Yong Mi Choi-Sledeski, Karen Brown, Robert J. Leadley, Gregory B. Poli, Vincent Mikol, Spada Alfred P, Yong Gong, Robert E. Kearney, Phillip Moxey, Charles J Kasiewski, Ross G. Bentley, Sébastien Maignan, Dennis Collussi, Pauls Henry W, Sam S. Rebello, Davis Roderick S, Valeria Chu, Gardner Charles J, Michael Becker, Jean-Pierre Guilloteau, Guyan Liang, Suzanne R Morgan
Publikováno v:
Journal of Medicinal Chemistry. 46:681-684
The discovery and SAR of ketopiperazino methylazaindole factor Xa inhibitors are described. Structure-activity data suggesting that this class of inhibitors does not bind in the canonical mode were confirmed by an X-ray crystal structure showing the
Autor:
Sebastian Maignan, Suzanne R Morgan, Robert J. Leadley, Valeria Chu, Gardner Charles J, Spada Alfred P, Pauls Henry W, Ross G. Bentley, Christopher T Dunwiddie, Klein Scott I, Jean-Pierre Guilloteau, Mark Czekaj, Karen Brown, Daniel L Cheney, Dennis J Colussi, Christopher L Heran, Kevin R. Guertin, Allison L Zulli, Yong Gong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1671-1674
Further optimization of the beta-aminoester class of factor Xa (fXa) inhibitors is described culminating in the identification of 9c (FXV673), a potent and selective factor Xa inhibitor with excellent in vivo anticoagulant activity. An X-ray structur
Autor:
Mu, Lan, Aguiar, Joacy, Ardati, Ali, Cao, Bin, Gardner, Charles J., Gillespy, Tim, Harris, Keith, Lim, Sungtaek, Marcus, Robert, Morize, Isabelle, Parkar, Ashfaq, Stefany, David, Li, Yi, Vaz, Roy J., Cirovic, Dragan A.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 January 2011 21(1):66-75
Autor:
Daniel L Cheney, Pauls Henry W, Christopher T Dunwiddie, Gardner Charles J, Kevin R. Guertin, Spada Alfred P, Allison L Zulli, Robert J. Leadley, Klein Scott I, Karen Brown, Valeria Chu, Dennis J Colussi, Mark Czekaj
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(12)
A systematic modification of the C(3) side-chain of the beta-aminoester class of factor Xa inhibitors and a survey of P(4) variations is described. These changes have resulted in the identification of sub-nanomolar inhibitors with improved selectivit
Autor:
Valeria Chu, Jack D. Newman, Scott I. Klein, Bruce F. Molino, Zaverio M. Ruggeri, John A. Barrett, Gardner Charles J, Mark Czekaj
Publikováno v:
Peptides 1990 ISBN: 9789072199089
Peptides 1990
Peptides 1990
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c67446f6fd084af179d33ed526ce261
https://doi.org/10.1007/978-94-011-3034-9_157
https://doi.org/10.1007/978-94-011-3034-9_157
Autor:
Guertin, Kevin R. kevin.guertin@roche.com, Gardner, Charles J.1, Klein, Scott I.1, Zulli, Allison L.1, Czekaj, Mark1, Gong, Yong1, Spada, Alfred P.1, Cheney, Daniel L.1, Maignan, Sebastian1, Guilloteau, Jean-Pierre1, Brown, Karen D.1, Colussi, Dennis J.1, Chu, Valeria1, Heran, Christopher L.1, Morgan, Suzanne R.1, Bentley, Ross G.1, Dunwiddie, Christopher T.1, Leadley, Robert J.1, Pauls, Henry W. henry.pauls@aventis.com
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. Jun2002, Vol. 12 Issue 12, p1671. 4p.
Publikováno v:
Transfusion Science. 13:ii
Autor:
Czekaj, Mark, Klein, Scott I, Guertin, Kevin R, Gardner, Charles J, Zulli, Allison L, Pauls, Henry W, Spada, Alfred P, Cheney, Daniel L, Brown, Karen D, Colussi, Dennis J, Chu, Valeria, Leadley, Robert J, Dunwiddie, Christopher T
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2002 12(12):1667-1670
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