Genetic drivers of human plasma metabolites that determine mortality in heart failure patients with reduced ejection fraction.

Autor: Revathi Venkateswaran V; Center for Individualized and Genomic Medicine Research, Henry Ford Hospital, Detroit, MI, United States., She R; Department of Public Health Science, Henry Ford Health, Detroit, MI, United States., Gui H; Center for Individualized and Genomic Medicine Research, Henry Ford Hospital, Detroit, MI, United States., Luzum JA; Center for Individualized and Genomic Medicine Research, Henry Ford Hospital, Detroit, MI, United States.; Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI, United States., Bryson TD; Center for Individualized and Genomic Medicine Research, Henry Ford Hospital, Detroit, MI, United States., Malouf ZE; Cardiovascular Division, Department of Medicine, Henry Ford Hospital, Detroit, MI, United States., Williams LK; Center for Individualized and Genomic Medicine Research, Henry Ford Hospital, Detroit, MI, United States., Sabbah HN; Cardiovascular Division, Department of Medicine, Henry Ford Hospital, Detroit, MI, United States., Gardell SJ; Translational Research Institute, Advent Health, Orlando, FL, United States., Lanfear DE; Center for Individualized and Genomic Medicine Research, Henry Ford Hospital, Detroit, MI, United States.; Cardiovascular Division, Department of Medicine, Henry Ford Hospital, Detroit, MI, United States.

Publikováno v: Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2024 Jul 09; Vol. 11, pp. 1409340. Date of Electronic Publication: 2024 Jul 09 (Print Publication: 2024).

Comprehensive interrogation of human skeletal muscle reveals a dissociation between insulin resistance and mitochondrial capacity.

Autor: Whytock KL; Translational Research Institute, AdventHealth, Orlando, Florida, United States., Pino MF; Translational Research Institute, AdventHealth, Orlando, Florida, United States., Sun Y; Icahn School of Medicine at Mount Sinai, New York City, New York, United States., Yu G; Translational Research Institute, AdventHealth, Orlando, Florida, United States., De Carvalho FG; Translational Research Institute, AdventHealth, Orlando, Florida, United States., Yeo RX; Translational Research Institute, AdventHealth, Orlando, Florida, United States., Vega RB; Translational Research Institute, AdventHealth, Orlando, Florida, United States., Parmar G; Department of Biochemistry Microbiology and Immunology, Faculty of Medicine, Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada., Divoux A; Translational Research Institute, AdventHealth, Orlando, Florida, United States., Kapoor N; Translational Research Institute, AdventHealth, Orlando, Florida, United States., Yi F; Translational Research Institute, AdventHealth, Orlando, Florida, United States., Cornnell H; Translational Research Institute, AdventHealth, Orlando, Florida, United States., Patten DA; Department of Biochemistry Microbiology and Immunology, Faculty of Medicine, Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada., Harper ME; Department of Biochemistry Microbiology and Immunology, Faculty of Medicine, Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada., Gardell SJ; Translational Research Institute, AdventHealth, Orlando, Florida, United States., Smith SR; Translational Research Institute, AdventHealth, Orlando, Florida, United States., Walsh MJ; Icahn School of Medicine at Mount Sinai, New York City, New York, United States., Sparks LM; Translational Research Institute, AdventHealth, Orlando, Florida, United States.

Publikováno v: American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2023 Oct 01; Vol. 325 (4), pp. E291-E302. Date of Electronic Publication: 2023 Aug 16.

Metabolic dysregulation impairs lymphocyte function during severe SARS-CoV-2 infection.

Autor: Gurshaney S; Cancer Division, Burnett School of Biomedical Science, College of Medicine, University of Central Florida, Orlando, FL, 32827, USA., Morales-Alvarez A; Cancer Division, Burnett School of Biomedical Science, College of Medicine, University of Central Florida, Orlando, FL, 32827, USA., Ezhakunnel K; Cancer Division, Burnett School of Biomedical Science, College of Medicine, University of Central Florida, Orlando, FL, 32827, USA., Manalo A; Cancer Division, Burnett School of Biomedical Science, College of Medicine, University of Central Florida, Orlando, FL, 32827, USA., Huynh TH; Cancer Division, Burnett School of Biomedical Science, College of Medicine, University of Central Florida, Orlando, FL, 32827, USA., Abe JI; Department of Cardiology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Unit 1451, Houston, TX, 77030, USA., Le NT; Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX, 77030, USA., Weiskopf D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA, 92037, USA., Sette A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA, 92037, USA.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA, 92037, USA., Lupu DS; AdventHealth Cancer Institute, AdventHealth Research Institute, Orlando, FL, 32804, USA., Gardell SJ; Translational Research Institute, AdventHealth Research Institute, Orlando, FL, 32804, USA., Nguyen H; Cancer Division, Burnett School of Biomedical Science, College of Medicine, University of Central Florida, Orlando, FL, 32827, USA. hung.nguyen@ucf.edu.

Publikováno v: Communications biology [Commun Biol] 2023 Apr 07; Vol. 6 (1), pp. 374. Date of Electronic Publication: 2023 Apr 07.

The TAS1R2 sweet taste receptor regulates skeletal muscle mass and fitness.

Autor: Serrano J; Biological Chemistry & Pharmacology, College of Medicine, The Ohio State University, Columbus, OH, USA., Boyd J; Biological Chemistry & Pharmacology, College of Medicine, The Ohio State University, Columbus, OH, USA., Mason C; Biological Chemistry & Pharmacology, College of Medicine, The Ohio State University, Columbus, OH, USA., Smith KR; Biological Chemistry & Pharmacology, College of Medicine, The Ohio State University, Columbus, OH, USA., Karolyi K; Biological Chemistry & Pharmacology, College of Medicine, The Ohio State University, Columbus, OH, USA., Kondo S; Biological Chemistry & Pharmacology, College of Medicine, The Ohio State University, Columbus, OH, USA., Brown IS; Biological Chemistry & Pharmacology, College of Medicine, The Ohio State University, Columbus, OH, USA., Maurya SK; Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, USA., Meshram NN; Biological Chemistry & Pharmacology, College of Medicine, The Ohio State University, Columbus, OH, USA., Serna V; Biological Chemistry & Pharmacology, College of Medicine, The Ohio State University, Columbus, OH, USA., Gilger J; Biological Chemistry & Pharmacology, College of Medicine, The Ohio State University, Columbus, OH, USA., Branch DA; Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, USA., Gardell SJ; Translational Research Institute, Advent Health, Orlando, FL, USA., Baskin KK; Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, USA., Ayala JE; Molecular Physiology & Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA., Pratley RE; Translational Research Institute, Advent Health, Orlando, FL, USA., Goodpaster BH; Translational Research Institute, Advent Health, Orlando, FL, USA., Coen PM; Translational Research Institute, Advent Health, Orlando, FL, USA., Kyriazis GA; Biological Chemistry & Pharmacology, College of Medicine, The Ohio State University, Columbus, OH, USA.

Publikováno v: Research square [Res Sq] 2023 Feb 09. Date of Electronic Publication: 2023 Feb 09.

Discovery of 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea as a potent NAMPT (nicotinamide phosphoribosyltransferase) activator with attenuated CYP inhibition.

Autor: Akiu M; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. Electronic address: akiu.mayuko.bs@daiichisankyo.co.jp., Tsuji T; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan., Sogawa Y; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan., Terayama K; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan., Yokoyama M; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan., Tanaka J; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan., Asano D; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan., Sakurai K; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan., Sergienko E; Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA., Sessions EH; Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA., Gardell SJ; Translational Research Institute, AdventHealth, Orlando, FL 32804, USA., Pinkerton AB; Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA., Nakamura T; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 Jul 01; Vol. 43, pp. 128048. Date of Electronic Publication: 2021 Apr 19.