Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Gard Nelson"'
Autor:
Shiho Tanaka, Gard Nelson, C. Anders Olson, Oleksandr Buzko, Wendy Higashide, Annie Shin, Marcos Gonzalez, Justin Taft, Roosheel Patel, Sofija Buta, Ashley Richardson, Dusan Bogunovic, Patricia Spilman, Kayvan Niazi, Shahrooz Rabizadeh, Patrick Soon-Shiong
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The SARS-CoV-2 variants replacing the first wave strain pose an increased threat by their potential ability to escape pre-existing humoral protection. An angiotensin converting enzyme 2 (ACE2) decoy that competes with endogenous ACE2 for bin
Externí odkaz:
https://doaj.org/article/4c4a182a1df54a5cb62090f68bebf693
Autor:
Marcos Gonzalez, Kayvan Niazi, Oleksandr Buzko, Wendy Higashide, Ashley Richardson, Shiho Tanaka, Gard Nelson, Shahrooz Rabizadeh, Sofija Buta, Justin Taft, Roosheel S. Patel, Annie Shin, Patrick Soon-Shiong, C. Anders Olson, Patricia Spilman, Dusan Bogunovic
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
The SARS-CoV-2 variants replacing the first wave strain pose an increased threat by their potential ability to escape pre-existing humoral protection. An angiotensin converting enzyme 2 (ACE2) decoy that competes with endogenous ACE2 for binding of t
Autor:
Kayvan Niazi, Patricia Spilman, Shiho Tanaka, Roosheel S. Patel, A. Olson, Annie Shin, Patrick Soon-Shiong, Gard Nelson, Shahrooz Rabizadeh, Justin Taft, Sofija Buta, Dusan Bogunovic, Oleksandr Buzko, Wendy Higashide, Gonzales M, Marta Martín-Fernández
The highly-transmissible SARS-CoV-2 variants now replacing the first wave strain pose an increased threat to human health by their ability, in some instances, to escape existing humoral protection conferred by previous infection, neutralizing antibod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e834be30a6b65de498c547442d95c478
https://doi.org/10.1101/2021.03.09.434641
https://doi.org/10.1101/2021.03.09.434641
Autor:
Oleksandr Buzko, Gard Nelson, Shahrooz Rabizadeh, Patrick Soon-Shiong, Patricia Spilman, Kayvan Niazi
Rapidly spreading SARS-CoV-2 variants present not only an increased threat to human health due to the confirmed greater transmissibility of several of these new strains but, due to conformational changes induced by the mutations, may render first-wav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::359bfb29d460db116b8914b45f6f81cc
https://doi.org/10.1101/2021.01.13.426558
https://doi.org/10.1101/2021.01.13.426558
Autor:
Gard Nelson, Aaron Bassett, Oleksandr Buzko, Patricia Spilman, Shahrooz Rabizadeh, Kayvan Niazi, Patrick Soon-Shiong
The Receptor Binding Domain (RBD) of the SARS-CoV-2 surface spike (S) protein interacts with host angiotensin converting enzyme 2 (ACE2) to gain entry to host cells and initiate infection1–3. Detailed, accurate understanding of key interactions bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77ac4226906f8d37b58176169dff035d
https://doi.org/10.1101/2020.12.11.422055
https://doi.org/10.1101/2020.12.11.422055
Autor:
Ross C. Walker, Daniel J. Mermelstein, J. Andrew McCammon, Charles Y. Lin, Gard Nelson, Rachael Kretsch
Publikováno v:
Journal of Computational Chemistry. 39:1354-1358
Alchemical free energy (AFE) calculations based on molecular dynamics (MD) simulations are key tools in both improving our understanding of a wide variety of biological processes and accelerating the design and optimization of therapeutics for numero
Autor:
Gard Nelson, Daniel J. Mermelstein, Ross C. Walker, Charles Y. Lin, Rachael Kretsch, J. Andrew McCammon
Publikováno v:
Journal of computational chemistry, vol 39, iss 19
Alchemical free energy calculations (AFE) based on molecular dynamics (MD) simulations are key tools in both improving our understanding of a wide variety of biological processes and accelerating the design and optimization of therapeutics for numero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1045cffd7b802fb49cd409819d2c9c
https://doi.org/10.1101/247692
https://doi.org/10.1101/247692
Publikováno v:
Journal of Chemical Theory and Computation
Accurately calculating a weak acid’s pKa from simulations remains a challenging task. We report a multiscale theoretical approach to calculate the free energy profile for acid ionization, resulting in accurate absolute pKa values in addition to ins
Publikováno v:
Journal of Chemical Theory and Computation. 14:1169-1169
Autor:
Paul B. Savage, Jason Nielsen, Xin-Zhong Lai, Yanshu Feng, Yang Li, Gard Nelson, Matthew R. Linford, Carl Genberg
Publikováno v:
ACS Symposium Series ISBN: 9780841274303
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96fb03f753578d089030cf1d28f5aa29
https://doi.org/10.1021/bk-2008-0984.ch005
https://doi.org/10.1021/bk-2008-0984.ch005