Evolution of SARS-CoV-2 spike trimers towards optimized heparan sulfate cross-linking and inter-chain mobility.

Autor: Froese J; Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Waldeyerstrasse 15, D-48149, Münster, Germany., Mandalari M; Istituto di Ricerche Chimiche e Biochimiche 'G. Ronzoni', Via Giuseppe Colombo 81, Milano, 20133, Italy.; Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, Milano, 20133, Italy., Civera M; Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, Milano, 20133, Italy., Elli S; Istituto di Ricerche Chimiche e Biochimiche 'G. Ronzoni', Via Giuseppe Colombo 81, Milano, 20133, Italy., Pagani I; Viral Pathogenesis and Biosafety Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Vicenzi E; Viral Pathogenesis and Biosafety Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Garcia-Monge I; School of Biomedical Sciences, Faculty of Biological Sciences, School of Physics and Astronomy, Faculty of Engineering and Physical Sciences, Astbury Centre for Structural Molecular Biology, and Bragg Centre for Materials Research, University of Leeds, Leeds, LS2 9JT, UK., Di Iorio D; Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Waldeyerstrasse 15, D-48149, Münster, Germany., Frank S; Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Waldeyerstrasse 15, D-48149, Münster, Germany., Bisio A; Istituto di Ricerche Chimiche e Biochimiche 'G. Ronzoni', Via Giuseppe Colombo 81, Milano, 20133, Italy., Lenhart D; Bene PharmaChem GmbH and Co.KG, Geretsried, Germany., Gruber R; Bene PharmaChem GmbH and Co.KG, Geretsried, Germany., Yates EA; Department of Biochemistry, Systems and Cell Biology, Institute of Molecular, Integrative and Systems Biology, University of Liverpool, Liverpool, L69 7ZB, UK., Richter RP; School of Biomedical Sciences, Faculty of Biological Sciences, School of Physics and Astronomy, Faculty of Engineering and Physical Sciences, Astbury Centre for Structural Molecular Biology, and Bragg Centre for Materials Research, University of Leeds, Leeds, LS2 9JT, UK., Guerrini M; Istituto di Ricerche Chimiche e Biochimiche 'G. Ronzoni', Via Giuseppe Colombo 81, Milano, 20133, Italy., Wegner SV; Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Waldeyerstrasse 15, D-48149, Münster, Germany., Grobe K; Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Waldeyerstrasse 15, D-48149, Münster, Germany. kgrobe@uni-muenster.de.

Publikováno v: Scientific reports [Sci Rep] 2024 Dec 31; Vol. 14 (1), pp. 32174. Date of Electronic Publication: 2024 Dec 31.