Chromatin alterations in the aging lung change progenitor cell activity

Autor: Carla F. Kim, Ho Sui Sj, Rowbotham Sp, Yoon J, Rodrick T. Bronson, Moye A, Fahey C, Wong I, Garcia de Alba Rivas C, Patrizia Pessina, Chongsaritsinsuk J, Jie Li

The lung contains multiple progenitor cell types that respond to damage, but how their responses are choreographed and why they decline with age is poorly understood. We report that histone H3 lysine 9 di-methylation (K9me2), mediated by histone meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c7652c0bd2c0336a61a2e45c73e1fb1
https://doi.org/10.1101/2021.07.15.452072

Human Airway and Alveolar Organoids from BAL Fluid.

Autor: Liu MY; Stem Cell Program, Division of Hematology/Oncology, and.; Division of Pulmonary and Critical Care Medicine and.; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin., Chen B; Stem Cell Program, Division of Hematology/Oncology, and., Borji M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Garcia de Alba Rivas C; Stem Cell Program, Division of Hematology/Oncology, and., Dost AFM; Stem Cell Program, Division of Hematology/Oncology, and.; Hubrecht Institute for Developmental Biology and Stem Cell Research, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, the Netherlands., Moye AL; Stem Cell Program, Division of Hematology/Oncology, and., Movval Abdulla N; Division of Pulmonary and Critical Care Medicine and., Paschini M; Stem Cell Program, Division of Hematology/Oncology, and., Rollins SD; Division of Pulmonary Medicine, Boston Children's Hospital, Boston, Massachusetts.; Department of Medicine and., Wang R; Division of Pulmonary Medicine, Boston Children's Hospital, Boston, Massachusetts.; Department of Medicine and., Schnapp LM; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin., Khalil HA; Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts., Wu CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Medicine and., Sharma NS; Division of Pulmonary and Critical Care Medicine and.; Division of Pulmonary and Critical Care, Veterans Affairs Medical Center, West Roxbury, Boston, Massachusetts; and., Kim CF; Stem Cell Program, Division of Hematology/Oncology, and.; Division of Pulmonary Medicine, Boston Children's Hospital, Boston, Massachusetts.; Department of Genetics, Harvard Medical School, Boston, Massachusetts.; Harvard Stem Cell Institute, Cambridge, Massachusetts.

Publikováno v: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2024 Jun 15; Vol. 209 (12), pp. 1501-1504.