Extracellular vesicle-miRNAs as liquid biopsy biomarkers for disease identification and prognosis in metastatic colorectal cancer patients

Autor: Jose Luis Garcia Puche, Alba Rodríguez Martínez, José Exposito Hernandez, Diego Perez, Alba Ortigosa Palomo, Ma Jose Serrano, Agustín Robles Remacho, Francisco Gabriel Ortega Sánchez, Mayte Delgado Ureña, José Antonio Lorente Acosta

Publikováno v: Digibug. Repositorio Institucional de la Universidad de Granada
instname
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Scientific Reports

We would like to extend our gratitude to the all the patients and the healthy volunteers who participated in the study, as well as the University of Granada, Biomedicine PhD program. This work was supported by Roche Spain, the PhD grant from the Univ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db86fcd46135d757844ffe92a3c2990e
https://www.nature.com/articles/s41598-020-60212-1.pdf

Extracellular vesicle-miRNAs as liquid biopsy biomarkers for disease identification and prognosis in metastatic colorectal cancer patients.

Autor: de Miguel Pérez D; GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, Liquid biopsy and metastasis research group, PTS Granada, Avenida de la Ilustración 114, 18016, Granada, Spain.; Laboratory of Genetic Identification, Legal Medicine and Toxicology Department, Faculty of Medicine, University of Granada, Granada, Spain., Rodriguez Martínez A; GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, Liquid biopsy and metastasis research group, PTS Granada, Avenida de la Ilustración 114, 18016, Granada, Spain.; Laboratory of Genetic Identification, Legal Medicine and Toxicology Department, Faculty of Medicine, University of Granada, Granada, Spain., Ortigosa Palomo A; GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, Liquid biopsy and metastasis research group, PTS Granada, Avenida de la Ilustración 114, 18016, Granada, Spain., Delgado Ureña M; Integral Oncology Division, University Hospital Virgen de las Nieves, IBS Granada, Instituto de Investigación Biosanitaria de Granada, 18012, Granada, Spain., Garcia Puche JL; GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, Liquid biopsy and metastasis research group, PTS Granada, Avenida de la Ilustración 114, 18016, Granada, Spain.; Integral Oncology Division, University Hospital Virgen de las Nieves, IBS Granada, Instituto de Investigación Biosanitaria de Granada, 18012, Granada, Spain., Robles Remacho A; GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, Liquid biopsy and metastasis research group, PTS Granada, Avenida de la Ilustración 114, 18016, Granada, Spain., Exposito Hernandez J; Integral Oncology Division, University Hospital Virgen de las Nieves, IBS Granada, Instituto de Investigación Biosanitaria de Granada, 18012, Granada, Spain., Lorente Acosta JA; GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, Liquid biopsy and metastasis research group, PTS Granada, Avenida de la Ilustración 114, 18016, Granada, Spain.; Laboratory of Genetic Identification, Legal Medicine and Toxicology Department, Faculty of Medicine, University of Granada, Granada, Spain., Ortega Sánchez FG; Balearic Islands Health Research Institute (IdISBa), 07010, Palma de Mallorca, Spain. franciscogabriel.ortega@ssib.es.; Laboratory of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands. franciscogabriel.ortega@ssib.es., Serrano MJ; GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, Liquid biopsy and metastasis research group, PTS Granada, Avenida de la Ilustración 114, 18016, Granada, Spain. mjose.serrano@genyo.es.; Integral Oncology Division, University Hospital Virgen de las Nieves, IBS Granada, Instituto de Investigación Biosanitaria de Granada, 18012, Granada, Spain. mjose.serrano@genyo.es.

Publikováno v: Scientific reports [Sci Rep] 2020 Mar 04; Vol. 10 (1), pp. 3974. Date of Electronic Publication: 2020 Mar 04.

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Autor: Banuelos-Sanchez G; Department of Medicinal and Organic Chemistry, Faculty of Pharmacy, University of Granada, Campus de Cartuja, s/n 18071 Granada, Spain., Sanchez L; GENYO. Centro de Genómica e Investigación Oncológica: Pfizer-Universidad de Granada-Junta de Andalucía, Avenida de la Ilustración 114, PTS Granada, 18016 Granada, Spain., Benitez-Guijarro M; GENYO. Centro de Genómica e Investigación Oncológica: Pfizer-Universidad de Granada-Junta de Andalucía, Avenida de la Ilustración 114, PTS Granada, 18016 Granada, Spain., Sanchez-Carnerero V; GENYO. Centro de Genómica e Investigación Oncológica: Pfizer-Universidad de Granada-Junta de Andalucía, Avenida de la Ilustración 114, PTS Granada, 18016 Granada, Spain., Salvador-Palomeque C; GENYO. Centro de Genómica e Investigación Oncológica: Pfizer-Universidad de Granada-Junta de Andalucía, Avenida de la Ilustración 114, PTS Granada, 18016 Granada, Spain., Tristan-Ramos P; GENYO. Centro de Genómica e Investigación Oncológica: Pfizer-Universidad de Granada-Junta de Andalucía, Avenida de la Ilustración 114, PTS Granada, 18016 Granada, Spain; Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, Campus Universitario de Cartuja, 18071 Granada, Spain., Benkaddour-Boumzaouad M; GENYO. Centro de Genómica e Investigación Oncológica: Pfizer-Universidad de Granada-Junta de Andalucía, Avenida de la Ilustración 114, PTS Granada, 18016 Granada, Spain., Morell S; GENYO. Centro de Genómica e Investigación Oncológica: Pfizer-Universidad de Granada-Junta de Andalucía, Avenida de la Ilustración 114, PTS Granada, 18016 Granada, Spain., Garcia-Puche JL; GENYO. Centro de Genómica e Investigación Oncológica: Pfizer-Universidad de Granada-Junta de Andalucía, Avenida de la Ilustración 114, PTS Granada, 18016 Granada, Spain., Heras SR; GENYO. Centro de Genómica e Investigación Oncológica: Pfizer-Universidad de Granada-Junta de Andalucía, Avenida de la Ilustración 114, PTS Granada, 18016 Granada, Spain; Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, Campus Universitario de Cartuja, 18071 Granada, Spain., Franco-Montalban F; Department of Medicinal and Organic Chemistry, Faculty of Pharmacy, University of Granada, Campus de Cartuja, s/n 18071 Granada, Spain., Tamayo JA; Department of Medicinal and Organic Chemistry, Faculty of Pharmacy, University of Granada, Campus de Cartuja, s/n 18071 Granada, Spain. Electronic address: jtamayo@ugr.es., Garcia-Perez JL; GENYO. Centro de Genómica e Investigación Oncológica: Pfizer-Universidad de Granada-Junta de Andalucía, Avenida de la Ilustración 114, PTS Granada, 18016 Granada, Spain; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK. Electronic address: jose.garcia-perez@igmm.ed.ac.uk.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2019 Aug 15; Vol. 26 (8), pp. 1095-1109.e14. Date of Electronic Publication: 2019 May 30.

Dormant Circulating Tumor Cells in Prostate Cancer: Therapeutic, Clinical and Biological Implications.

Autor: Alvarez-Cubero MJ, Vázquez-Alonso F, Puche-Sanz I, Ortega FG, Martin-Prieto M, Garcia-Puche JL, Pascual-Geler M, Lorente JA, Cozar-Olmo JM, Serrano MJ; GENYO, Centre for Genomics and Oncological Research, Pfizer / University of Granada / Andalusian Regional Government, PTS Granada Av. de la Ilustración, 114 - 18016, GRANADA, Spain. mjose.serrano@genyo.es.

Publikováno v: Current drug targets [Curr Drug Targets] 2016; Vol. 17 (6), pp. 693-701.

Combined analysis of copy number alterations by single-nucleotide polymorphism array and MYC status in non-metastatic breast cancer patients: comparison according to the circulating tumor cell status.

Autor: Nadal R; Institut de Recerca Contra la Leucèmia Josep Carreras, Ctra. de Can Ruti, Camí de les Escoles s/n. Edifici IMPPC, 08916, Badalona, Barcelona, Spain, rnadal2286@gmail.com., Salido M, Nonell L, Rodríguez-Rivera M, Puigdecanet E, Garcia-Puche JL, Macià M, Corominas JM, Serrano MJ, Lorente JA, Solé F

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