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pro vyhledávání: '"Garcia, Tanya P"'
In Huntington's disease research, a current goal is to understand how symptoms change prior to a clinical diagnosis. Statistically, this entails modeling symptom severity as a function of the covariate 'time until diagnosis', which is often heavily r
Externí odkaz:
http://arxiv.org/abs/2409.07795
While right-censored time-to-event outcomes have been studied for decades, handling time-to-event covariates, also known as right-censored covariates, is now of growing interest. So far, the literature has treated right-censored covariates as distinc
Externí odkaz:
http://arxiv.org/abs/2409.04684
Autor:
Ashner, Marissa C., Garcia, Tanya P.
Despite its drawbacks, the complete case analysis is commonly used in regression models with missing covariates. Understanding when implementing complete cases will lead to consistent parameter estimation is vital before use. Here, our aim is to demo
Externí odkaz:
http://arxiv.org/abs/2303.16119
To select outcomes for clinical trials testing experimental therapies for Huntington disease, a fatal neurodegenerative disorder, analysts model how potential outcomes change over time. Yet, subjects with Huntington disease are often observed at diff
Externí odkaz:
http://arxiv.org/abs/2303.01602
Autor:
Lotspeich, Sarah C., Garcia, Tanya P.
Modeling symptom progression to identify informative subjects for a new Huntington's disease clinical trial is problematic since time to diagnosis, a key covariate, can be heavily censored. Imputation is an appealing strategy where censored covariate
Externí odkaz:
http://arxiv.org/abs/2209.04716
Autor:
Holcomb, David A., Christensen, Ariel, Hoffman, Kelly, Lee, Allison, Blackwood, A. Denene, Clerkin, Thomas, Gallard-Góngora, Javier, Harris, Angela, Kotlarz, Nadine, Mitasova, Helena, Reckling, Stacie, de los Reyes, Francis L., III, Stewart, Jill R., Guidry, Virginia T., Noble, Rachel T., Serre, Marc L., Garcia, Tanya P., Engel, Lawrence S.
Publikováno v:
In Science of the Total Environment 15 November 2024 951
Publikováno v:
Biometrical Journal, vol. 64, pp. 858-862, 2022
Analysts are often confronted with censoring, wherein some variables are not observed at their true value, but rather at a value that is known to fall above or below that truth. While much attention has been given to the analysis of censored outcomes
Externí odkaz:
http://arxiv.org/abs/2109.11989
For Huntington disease, identification of brain regions related to motor impairment can be useful for developing interventions to alleviate the motor symptom, the major symptom of the disease. However, the effects from the brain regions to motor impa
Externí odkaz:
http://arxiv.org/abs/2007.06076
Autor:
Senn, MacKenzie K., Goodarzi, Mark O., Ramesh, Gautam, Allison, Matthew A., Graff, Mariaelisa, Young, Kristin L., Talavera, Gregory A., McClain, Amanda C., Garcia, Tanya P., Rotter, Jerome I., Wood, Alexis C.
Publikováno v:
In Nutrition, Metabolism and Cardiovascular Diseases December 2023 33(12):2428-2439
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