Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients

Autor: Ridker, P. M., Revkin, J., Amarenco, P., Brunell, R., Civeira, F., Flather, M., Glynn, R. J., Gregoire, J., Jukema, J. W., Karpov, Y., Kastelein, J. J. P., Koenig, W., Lorenzatti, A., Manga, P., Masiukiewicz, U., Miller, M., Mosterd, A., Murin, J., Nicolau, J. C., Nissen, S., Ponikowski, P., Santos, R. D., Schwartz, P. F., Soran, H., White, H., Wright, R. S., Vrablik, M., Yunis, C., Shear, C. L., Tardif, Conde D, J. -C., Colquhoun, D, Missault, L, Grégoire, J, Gao, R, Urina, M, Solar, M, Jensen, Hk, Grobbee, D, Savolainen, M, Schiele, Fn, Montalescot, G, Edes, I, Blake, G, Lotan, C, Maggioni, A, Savonitto, S, Lee, Cw, Leiva Pons JL, Dan, Ga, Cortada, Jb, Mellbin, L, Kahan, T, Noble, S, Hwang, Jj, Sritara, P, Tökgozoğlu, L, Tarasenko, L, Borer, Js, Black, H, Carmena, R, Furie, Kl, Mcmurray, J, Neaton, J, Zannad, F, O’Neill, B, Welty, F, Mcnamara, R, Chun, H, Abbott, Jd, Jacoby, D, Mcpherson, C, Jadbabaie, F, Pinto, D, Mccullough, L, Silverman, Ie, Sansing, Lh, Dearborn-Tomazos, J, Foody, J, Schindler, J, Piazza, G, Chakrabarti, A, Pride, Y, Gelfand, E, Baultrukonis, D, Chaudhuri, S, Frederich, R, Johnson, M, Mridha, K, Powell, C, Wang, E, Wei, C, Anderson, P, Buonanno, M, Epsley, C, Evans, B, Frolova, M, Goetsch, M, Hessinger, D, Ikehara, E, Ivanac, K, Kizko, J, Le, K, McNally-Dufort, C, Morocco, T, Nadkarni, S, Nissen, T, Nye, R, Pak, R, Pence, D, Redifer, P, Schwartz, W, Sattler, C, Schade, R, Sullivan, B, Wegner, J, Alvarez, Ca, Budassi, N, Vogel, Dr, Avaca, H, Conde, Dg, Estol, Cc, Gelersztein, E, Glenny, Ja, Hershson, Ar, Bruno, Rl, Maffei, Le, Soler, Jm, Zaidman, Cj, Carnero, Gs, Colombo, Hr, Jure, Ho, Luquez, Ha, Ramos, Hr, Resk, Jh, Rusculleda, Mm, Ulla, Mr, Caccavo, A, Farias, Ef, Wenetz, Lm, Cabella, Pr, Cuadrado, Ja, Chahin, M, Mackinnon, Ij, Zarandon, Rb, Schmidberg, J, Fernandez, Aa, Montana, O, Codutti, Or, Gorosito, Vm, Maldonado, N, Sala, J, De La Fuente RA, Casabella, Te, Di Gennaro JP, Guerrero, Ra, Alvarez, Ms, Berli, M, Botta, Ce, Montenegro, Ee, Vico, Ml, Begg, A, Lehman, R, Gilfillan, Cp, D'Emden, M, Markovic, Tp, Sullivan, D, Aroney, C, Stranks, Sn, Crimmins, Ds, Arstall, M, Van Gaal, W, Davis, T, Aylward, Pe, Amerena, J, William, M, Proietto, J, Purnell, Pw, Singh, B, Arya, Kw, Dart, Am, Thompson, P, Davis, Sm, Carroll, Pa, De Looze, F, Jayasinghe, R, Bhindi, R, Buysschaert, I, Sarens, T, van de Borne, P, Scott, Bp, Roosen, J, Cools, F, Missault, Lh, Debroye, C, Schoors, Df, Hollanders, G, Schroe, Hh, De Sutter, J, Hermans, K, Carlier, M, van Landegem, P, Verwerft, J, Mulleners, T, Delforge, Md, Soufflet, V, Elegeert, I, Descamps, Os, Janssens, S, Lemmens, Rc, Desfontaines, P, Scheen, A, Heijmans, S, Capiau, L, Vervoort, G, Carlier, Sg, Faes, D, Alzand, B, Keuleers, S, De Wolf, L, Thoeng, J, De Bruyne, L, de Santos MO, Felicio, Js, Areas, Ca, Figueiredo, El, Michalaros, Yl, Neuenschwander, Fc, Reis, G, Saad, Ja, Kormann, Ap, Nascimento, Cv, Precoma, Db, Abib, E Jr, dos Santos FR, Mello, Yg, Saraiva, Jf, Rech, Rl, Cerci, R, Fortes, Ja, Rossi, Pr, de Lima, e Silva FA, Hissa, M, Silva, Rp, de Souza WK, Guimarães Filho FV, Mangili, Oc, de Oliveira Paiva MS, Tumelero, R, Abrantes, Ja, Caramori, Pr, Dutra, Op, Leaes, Pe, Manenti, Er, Polanczyk, Ca, Bandeira, e Farias FA, de Moraes Junior JB, Russo, La, Alves AR Jr, Dracoulakis, Md, Ritt, Le, Saporito, Wf, Herdy, Ah, Maia, Ln, Sternieri, Mv, Ayoub, Jc, Bianco, Ht, da Costa FA, Eliaschewitz, Fg, Fonseca, Fa, Nakandakare, Er, Bonansea, Tc, Castro, Nm, de Barros, e Silva PG, Smith, P, Botelho, Rv, Resende, Es, Barbieri, Ds, Hernandes, Me, Bajaj, H, Beaudry, P, Berlingieri, Jc, Salter, Tj, Ajala, B, Anderson, Tj, Nanji, A, Ross, S, Pandey, S, Desrosiers, D, Gaudet, D, Moran, G, Csanadi, Ma, St-Amour, E, Cusimano, S, Halperin, Fa, Babapulle, M, Vizel, S, Petrella, J, Spence, Jd, Gupta, N, Tellier, G, Bourgeois, R, Gregóire, Jc, Wesson, T, Zadra, R, Twum-Barima, Dy, Cha, Jy, Hartleib, Mc, Bergeron, J, Chouinard, G, Mcpherson, Tp, Searles, G, Peterson, Sr, Mukherjee, A, Lepage, S, Conway, Jr, Kouz, Sm, Dion, D, Pesant, Y, Cheung, Ss, Goldenberg, Rm, Aronson, R, Gupta, Ak, O’Mahoney, M, Pliamm, L, Teitelbaum, I, Hoag, Gn, Nadra, Ij, Yared, Z, Yao, Lc, Nguyen, T, Saunders, Kk, Potthoff, S, Varleta, P, Assef, V, Godoy, Jg, Olivares, C, Roman, O, Vejar, M, Montecinos, H, Pincetti, C, Li, Y, Wang, D, Li, J, Yang, X, Du, Y, Wang, G, Yang, P, Zhang, X, Xu, P, Zhao, Y, Chen, J, Li, S, Li, W, Zhang, L, Zhu, Y, Zhang, Y, Zhou, C, Wang, Y, Liu, F, Ma, Y, Ti, Z, Zeng, X, Zhou, Y, Cui, G, Li, D, Xue, L, Jiang, J, Lian, Y, He, Y, Mendoza, Ja, Bonfanti, Ja, Dada, Fa, Urina-Triana, Ma, Rodriguez, Wr, Sanchez, Ml, Lozno, Hy, Triana, Eh, Arambula, Rm, Rico-Carrillo, Ae, Gallo, Hj, Catano, Js, Jattin, Fg, Plazas, Ja, Gomez, Je, Botero-Lopez, R, Gomez, Ni, Munoz, Cf, Pelaez, Sv, Eraso, Am, Goyes, Ar, Elbl, L, Fiserova, N, Vesely, J, Wasserburger, B, Blaha, V, Vojacek, J, Maskova, P, Hutyra, M, Vrkoc, J, Hala, T, Vodnansky, P, Bocek, P, Cifkova, R, Bufka, V, Ceska, R, Machkova, M, Zidkova, E, Lukac, M, Mikusova, T, Kellnerova, I, Kuchar, L, Ferkl, R, Cech, V, Zemek, S, Monhart, Z, Davidsen, F, Joensen, A, Lihn, As, Rasmussen, Tk, Wiggers, H, Lindgren, Lm, Schmidt, U, Galatius, S, Sillesen, H, Bronnum Schou, J, Thomsen, Kk, Urhammer, S, Jeppensen, J, Schou, M, May, O, Steffensen, R, Nielsen, Wb, Nielesen, T, Jepsen, Jm, Rai, A, Sykulski, R, Andersen, Lt, Rickers, H, Frost, L, Lomholdt, J, Egstrup, K, Wermuth, S, Klausen, L, Lassus, J, Palomaki, A, Khari, J, Tatlisumak, T, Kekki, S, Vanttinen, E, Strandberg, A, Valtonen, M, Sia, Sm, Nerg, O, Puhakka, M, Strand, J, Timonen, M, Levola, J, Arstila, L, Taurio, J, Kantola, I, Suomi, J, Humaloja, K, Askonen, K, Schiele, F, Sibon, I, Zemour, G, Goube, P, Petit, C, Chati, Z, Range, G, Rabahi, F, Rihani, R, Bergerot, C, Roubille, F, Boye, A, Probst, V, Ferrari, E, Cayla, G, Thouvenot, E, Delarche, N, Couffinhal, T, Coisne, D, Paillard, F, Elbaz, M, Decoulx, E, Angoulvant, D, Agraou, B, Caudmont, S, Berrouschot, J, Lauer, B, Schoell, I, Trenk, D, Derwahl, Km, Khariouzov, A, Proepper, F, Stawowy, P, Da Stephan, U, Stoessel, J, Voehringer, Hf, Dorsel, T, Stellbrink, C, Rinke, A, Northroff, J, Bourhaial, H, Stratmann, M, Wetzel, T, Axthelm, C, Guenzel, A, Weigmann, I, Faghih, M, Hagemann, D, Schaefer, A, Weber, D, Luedemann, J, Contzen, C, Kornmann, Mo, Winkelmann, B, Simon, J, Felix, S, Brauer, C, Laufs, U, Schmidt, E, Marten, I, Licka, M, Heisters, J, Appel, Kf, Kleinecke-Pohl, U, Klein, C, von Hodenberg EF, Maus, O, Sigal, H, Taeschner, H, Schwimmbeck, P, Lemke, B, Perings, C, Illies, G, Pfuetzner, A, Salbach, P, Hengstenberg, C, Kohler, A, Mudra, H, Behnke, T, Baar, M, Jeserich, M, Scholz, G, Naudts, I, Voller, H, Herrmann, Hj, von Engelhardt CB, Gerke, S, Pohlmeier, L, Schaufele, T, Woehrle, J, Al-Zoebi, A, Horacek, T, Peterfai, E, Kemeny, V, Lakatos, F, Bod, E, Andrassy, P, Andreka, P, Balo, T, Davidovits, Z, Laszlo, Z, Nagy, K, Papp, A, Somogyi, A, Toldy-Schedel, E, Vertes, A, Voros, P, Paragh, G, Martyin, T, Hajdu, C, Deak, L, Farago, K, Nagy, A, Kirschner, R, Koszegi, Z, Zilahi, Z, Toth, K, Wittmann, I, Bajcsi, D, Reiber, I, Toth, L, Benczur, B, Nagy, L, Sydo, T, Lupkovics, G, Oroszlan, T, Crean, P, Mahon, Ng, Mcadam, B, Macneill, B, Katz, A, Tsalihin, D, Vazan, A, Eitan, A, Lewis, Bs, Gavish, D, Wainstein, J, Mosenzon, O, Mosseri, M, Vishlitzky, V, Atar, S, Nseir, Wb, 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Gillespie, E, Bybee, Ka, Moriarty, Pm, Savin, V, Agaiby, Jm, Melucci, Mb, Jantzi, Cm, Davidson, E, Smith, Wb, Treasure, Cb, Wakefield, Ph, Deck, K, Edris, Ma, Gilmore, Rm, Seep, Mk, Andersen, Jl, Detweiler, Ro, Rosenfeld, Jc, Strobl, Dj, Steinhoff, Jp, Adams, A, Estevez, R, Molin, Cj, Kim, Cy, Dy, J, Fox, Ke, Farris, Nr, Wayne, Jd, Whitney, Rt, Randhawa, Pm, Mego, Dm, Macdolnald, L, Caputo, Rp, Rigolosi, R, Vannatta, B, Pacheco, Tr, El-Shahawy, M, Gonzalez, Ej, Guice, Mj, Cherlin, Rs, Bays, He, Shoukfeh, M, Morris, Fh, Loy, J, Vora, Sk, Staab, Pk, Frisoli, A, Kimmel, Ma, Cohen, Aj, Green, Cb, Whitlock, L, Butuk, Dj, Mccartney, Mj, Ables, Lr, Acosta, R, Alvarez, Jg, Barrera, Cm, Benitez, O, Berenguer, Ra, Breton, Cf, Chiong, R, Delgado, Mi, Dufreny, A, Fialkow, Ja, Franczek, S, Frias, Jj, Iglesias, C, Landron-Garcia, L, Llerena, Sn, Martinez, Rf, Miranda, Aa, Morytko, Ja, Rodriguez, Ij, Sotolongo, R, Suarez-Sarmiento, A, Terrelonge, Ae, Vaca, Ce, Venereo, Jm, Verdeza, C, Zeno, Ml, 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Publikováno v: The New England Journal of Medicine, 376, 16, pp. 1527-1539
New England Journal of Medicine
New England Journal of Medicine, Massachusetts Medical Society, 2017, 376 (16), pp.1527-1539. ⟨10.1056/NEJMoa1701488⟩
New England Journal of Medicine, 376(16), 1527-1539. MASSACHUSETTS MEDICAL SOCIETY
New England Journal of Medicine, 376(16), 1527. Massachussetts Medical Society
The New England Journal of Medicine, 376, 1527-1539
Department of Medicine Publications
Ridker, P M, Revkin, J, Amarenco, P, Brunell, R, Curto, M, Civeira, F, Flather, M, Glynn, R J, Gregoire, J, Jukema, J W, Karpov, Y, Kastelein, J J P, Koenig, W, Lorenzatti, A, Manga, P, Masiukiewicz, U, Miller, M, Mosterd, A, Murin, J, Nicolau, J C, Nissen, S, Ponikowski, P, Santos, R D, Schwartz, P F, Soran, H, White, H, Wright, R S, Vrablik, M, Yunis, C, Shear, C L, Tardif, J-C, SPIRE Cardiovascular Outcome Investigators & Michael Jepsen, J 2017, ' Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients ', The New England Journal of Medicine, vol. 376, no. 16, pp. 1527-1539 . https://doi.org/10.1056/NEJMoa1701488
New England Journal of Medicine, 376(16), 1527-1539
Zaguán. Repositorio Digital de la Universidad de Zaragoza
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New England journal of medicine, 376(16), 1527-1539. Massachussetts Medical Society

Item does not contain fulltext BACKGROUND: Bococizumab is a humanized monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and reduces levels of low-density lipoprotein (LDL) cholesterol. We sought to evaluate the e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48145f0e532c28c7df2dafc05d62159
https://hdl.handle.net/2066/182257

Direito, técnica, imagem: os limites e os fundamentos do humano

Autor: Barrientos-Parra, JD, De Matos, MVAB, Borges, PCC, Vanderburg, WH, Souza, PV, Troude-Chastenet, P, Rampin, TTD, Silva, LP, Corona, RB, Penna, JB, Faleiros Júnior, RG, Leite, T de SC, Silva, JL, Barbosa, VR, Garcia, DK

Esta coletânea de artigos foi desenvolvida a partir de reflexões produzidas em diferentes edições do Seminário Brasileiro sobre o Pensamento de Jacques Ellul, filósofo e sociólogo francês que discutiu, em mais de 50 livros e centenas de artig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______900::74cbdacf5d333e95deb28d6e6f57bb41
https://bura.brunel.ac.uk/handle/2438/25734

Estrogen-Dependent Upregulation of Adcyap1r1 Expression in Nucleus Accumbens Is Associated With Genetic Predisposition of Sex-Specific QTL for Alcohol Consumption on Rat Chromosome 4.

Autor: Spence JP; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States., Reiter JL; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States., Qiu B; Comparative Medical Center, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China., Gu H; Comparative Medical Center, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China., Garcia DK; Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, TX, United States., Zhang L; Comparative Medical Center, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China., Graves T; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States., Williams KE; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States., Bice PJ; Department of Psychology, Southeast Missouri State University, Cape Girardeau, MO, United States., Zou Y; Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, TX, United States., Lai Z; Department of Psychology, Southeast Missouri State University, Cape Girardeau, MO, United States., Yong W; Comparative Medical Center, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China., Liang T; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States.

Publikováno v: Frontiers in genetics [Front Genet] 2018 Dec 04; Vol. 9, pp. 513. Date of Electronic Publication: 2018 Dec 04 (Print Publication: 2018).

IGFBP7 Deletion Promotes Hepatocellular Carcinoma.

Autor: Akiel M; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia., Guo C; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia., Li X; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia., Rajasekaran D; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia., Mendoza RG; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia., Robertson CL; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia., Jariwala N; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia., Yuan F; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia., Subler MA; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia., Windle J; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia., Garcia DK; Greehey Children's Cancer Research Institute, Virginia Commonwealth University, Richmond, Virginia., Lai Z; Greehey Children's Cancer Research Institute, Virginia Commonwealth University, Richmond, Virginia., Chen HH; Greehey Children's Cancer Research Institute, Virginia Commonwealth University, Richmond, Virginia., Chen Y; Greehey Children's Cancer Research Institute, Virginia Commonwealth University, Richmond, Virginia.; Department of Epidemiology and Biostatistics, University of Texas Health Science Center San Antonio, San Antonio, Texas., Giashuddin S; Department of Pathology, New York Presbyterian Health System at Weill Cornell Medical College, New York, New York., Fisher PB; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia.; VCUMassey Cancer Center, Virginia Commonwealth University, Richmond, Virginia.; VCU Institute of Molecular Medicine (VIMM), Virginia Commonwealth University, Richmond, Virginia., Wang XY; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia.; VCUMassey Cancer Center, Virginia Commonwealth University, Richmond, Virginia.; VCU Institute of Molecular Medicine (VIMM), Virginia Commonwealth University, Richmond, Virginia., Sarkar D; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia. devanand.sarkar@vcuhealth.org.; VCUMassey Cancer Center, Virginia Commonwealth University, Richmond, Virginia.; VCU Institute of Molecular Medicine (VIMM), Virginia Commonwealth University, Richmond, Virginia.

Publikováno v: Cancer research [Cancer Res] 2017 Aug 01; Vol. 77 (15), pp. 4014-4025. Date of Electronic Publication: 2017 Jun 15.

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