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Self-assembly and intracellular delivery of DNA by a truncated fragment derived from the Trojan peptide Penetratin

Autor: Mello, Lucas R., Hamley, Ian W., Castelletto, Valeria, Garcia, Bianca B. M., Lourenço, Thiago C., Vassiliades, Sandra V., Alves, Wendel A., Han, Sang W., Silva, Emerson R.

Penetratin is a short Trojan peptide that attracts great interest in biomedical research for its capacity to translocate biological membranes. Herein, we study in detail both self-assembly and intracellular delivery of DNA by the heptamer KIWFQNR, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::725c54627cc82a3ae52b48dd940b0a27
https://centaur.reading.ac.uk/91719/1/article_KIW-R1clean.pdf

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Amyloid-like Self-Assembly of a Hydrophobic Cell-Penetrating Peptide and Its Use as a Carrier for Nucleic Acids.

Autor: de Mello LR; Departamento de Biofísica, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil., Porosk L; Institute of Technology, University of Tartu, Tartu 50411, Estonia., Lourenço TC; Departamento de Biofísica, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil., Garcia BBM; Departamento de Biofísica, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil., Costa CAR; Laboratório Nacional de Nanotecnologia (LNNano), Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), Campinas 13083-861, Brazil., Han SW; Departamento de Biofísica, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil., de Souza JS; Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André 09210580, Brazil., Langel Ü; Institute of Technology, University of Tartu, Tartu 50411, Estonia.; Department of Biochemistry and Biophysics, Stockholm University, Stockholm SE-10691, Sweden., da Silva ER; Departamento de Biofísica, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil.

Publikováno v: ACS applied bio materials [ACS Appl Bio Mater] 2021 Aug 16; Vol. 4 (8), pp. 6404-6416. Date of Electronic Publication: 2021 Aug 04.