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of 36
pro vyhledávání: '"García Martín, Juan Antonio"'
Autor:
Catalán, Pablo, García-Martín, Juan Antonio, Aguirre, Jacobo, Cuesta, José A., Manrubia, Susanna
All possible phenotypes are not equally accessible to evolving populations. In fact, only phenotypes of large size, i.e. those resulting from many different genotypes, are found in populations of sequences, presumably because they are easier to disco
Externí odkaz:
http://arxiv.org/abs/2304.05311
Autor:
Manrubia, Susanna, Cuesta, José A., Aguirre, Jacobo, Ahnert, Sebastian E., Altenberg, Lee, Cano, Alejandro V., Catalán, Pablo, Diaz-Uriarte, Ramon, Elena, Santiago F., García-Martín, Juan Antonio, Hogeweg, Paulien, Khatri, Bhavin S., Krug, Joachim, Louis, Ard A., Martin, Nora S., Payne, Joshua L., Tarnowski, Matthew J., Weiß, Marcel
Publikováno v:
Physics of Life Reviews 38, 55-106 (2021)
Understanding how genotypes map onto phenotypes, fitness, and eventually organisms is arguably the next major missing piece in a fully predictive theory of evolution. We refer to this generally as the problem of the genotype-phenotype map. Though we
Externí odkaz:
http://arxiv.org/abs/2002.00363
Akademický článek
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Publikováno v:
Europhysics Letters 123, 28001 (2018)
The evolutionary dynamics of molecular populations are strongly dependent on the structure of genotype spaces. The map between genotype and phenotype determines how easily genotype spaces can be navigated and the accessibility of evolutionary innovat
Externí odkaz:
http://arxiv.org/abs/1806.03885
Autor:
Torres-Vázquez, Beatriz, de Lucas, Ana María, García-Crespo, Carlos, García-Martín, Juan Antonio, Fragoso, Adrián, Fernández-Algar, María, Perales, Celia, Domingo, Esteban, Moreno, Miguel, Briones, Carlos
Publikováno v:
In Journal of Molecular Biology 15 April 2022 434(7)
Autor:
Garcia-Martin, Juan Antonio, Dotu, Ivan, Fernandez-Chamorro, Javier, Lozano, Gloria, Ramajo, Jorge, Martinez-Salas, Encarnacion, Clote, Peter
Motivation: RNA thermometers (RNATs) are cis-regulatory ele- ments that change secondary structure upon temperature shift. Often involved in the regulation of heat shock, cold shock and virulence genes, RNATs constitute an interesting potential resou
Externí odkaz:
http://arxiv.org/abs/1605.04468
Autor:
Manrubia, Susanna, Cuesta, José A., Aguirre, Jacobo, Ahnert, Sebastian E., Altenberg, Lee, Cano, Alejandro V., Catalán, Pablo, Diaz-Uriarte, Ramon, Elena, Santiago F., García-Martín, Juan Antonio, Hogeweg, Paulien, Khatri, Bhavin S., Krug, Joachim, Louis, Ard A., Martin, Nora S., Payne, Joshua L., Tarnowski, Matthew J., Weiß, Marcel
Publikováno v:
In Physics of Life Reviews September 2021 38:55-106
Conformational entropy for atomic-level, three dimensional biomolecules is known experimentally to play an important role in protein-ligand discrimination, yet reliable computation of entropy remains a difficult problem. Here we describe the first tw
Externí odkaz:
http://arxiv.org/abs/1508.05499
Several algorithms for RNA inverse folding have been used to design synthetic riboswitches, ribozymes and thermoswitches, whose activity has been experimentally validated. The RNAiFold software is unique among approaches for inverse folding in that (
Externí odkaz:
http://arxiv.org/abs/1505.04210
Autor:
Dotu, Ivan, Garcia-Martin, Juan Antonio, Slinger, Betty L., Mechery, Vinodh, Meyer, Michelle M., Clote, Peter
Publikováno v:
Nucl. Acids Res. (2014) 42 (18): 11752-11762
Nanotechnology and synthetic biology currently constitute one of the most innovative, interdisciplinary fields of research, poised to radically transform society in the 21st century. This paper concerns the synthetic design of ribonucleic acid molecu
Externí odkaz:
http://arxiv.org/abs/1408.2114