Biomarkers of the Endocannabinoid System in Substance Use Disorders

Autor: Navarrete F, García-Gutiérrez MS, Gasparyan A, Navarro D, López-Picón F, Morcuende Á, Femenía T, Manzanares J

Publikováno v: Biomolecules
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname

Despite substance use disorders (SUD) being one of the leading causes of disability and mortality globally, available therapeutic approaches remain ineffective. The difficulty in accurately characterizing the neurobiological mechanisms involved with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::63939c9ce96bda99ed67f2721390d526
https://fundanet.isabial.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=8493

Differences in Gene Expression of Endogenous Opioid Peptide Precursor, Cannabinoid 1 and 2 Receptors and Interleukin Beta in Peripheral Blood Mononuclear Cells of Patients With Refractory Failed Back Surgery Syndrome Treated With Spinal Cord Stimulation: Markers of Therapeutic Outcomes?

Autor: De Andrés J, Navarrete-Rueda F, Fabregat G, García-Gutiérrez MS, Monsalve-Dolz V, Harutyunyan A, Mínguez-Martí A, Rodriguez-Lopez R, Manzanares J

Publikováno v: NEUROMODULATION
r-FIHGUV. Repositorio Institucional de Producción Científica de la Fundación de Investigación del Hospital General de Valencia
instname
Neuromodulation
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante

OBJECTIVE: The use of spinal cord stimulation for patients with failed back surgery syndrome (FBSS) is very common. In order to better understand the mechanisms of action of spinal cord stimulation (SCS), our aim was to determine potential changes in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::00fc2d2f98c9f4e2e251ec8530444524
https://fundanet.fihgu.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=1558

Cannabis Use in Pregnant and Breastfeeding Women: Behavioral and Neurobiological Consequences

Autor: Navarrete F, García-Gutiérrez MS, Gasparyan A, Austrich-Olivares A, Femenía T, Manzanares J

Publikováno v: Frontiers in Psychiatry
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname

Nowadays, cannabis is the most consumed illicit drug. The global prevalence of the use of cannabis in 2017 was estimated in 188 million of people, 3.8% of worldwide population. Importantly, the legalization of cannabis in different countries, togethe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::f6e77d887d8fc697342edd7abe5edceb
https://fundanet.isabial.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=8711

Gender differences in the effects of cannabidiol on ethanol binge drinking in mice

Autor: Viudez-Martínez A, García-Gutiérrez MS, Manzanares J

Publikováno v: ADDICTION BIOLOGY
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
Consejo Superior de Investigaciones Científicas (CSIC)

The purpose of this study was to explore the effects of cannabidiol (CBD) on binge drinking and evaluate potential gender-related differences. To this aim, male and female C57BL/6J mice (n = 60 per sex) were exposed to the drinking in the dark (DID)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::cdb3c43bcd73a9c40bc9f9701f7b71e1
https://fundanet.isabial.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=6106

The Modulation of the Startle Reflex as Predictor of Alcohol Use Disorders in a Sample of Heavy Drinkers: A 4-Year Follow-Up Study

Autor: Jurado-Barba R, Duque A, López-Trabada JR, Martínez-Gras I, García-Gutiérrez MS, Navarrete F, López-Muñoz F, Jiménez-Arriero MÁ, Ávila C, Manzanares J, Rubio G

Publikováno v: ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname

BACKGROUND: Previous studies demonstrated that patients with alcohol use disorders (AUDs) show altered startle reflex responses to alcohol-related stimuli. However, there is little information about the role of these altered responses in the developm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::548168103851e325937a905c9ff8af99
https://fundanet.isabial.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=6253