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Human IL-6RhiTIGIT− CD4+ CD127lowCD25+ T cells display potent in vitro suppressive capacity and a distinct Th17 profile

Autor: Ferreira, Ricardo C., Rainbow, Daniel B., Rubio García, Arcadio, Pekalski, Marcin L., Porter, Linsey, Oliveira, João J., Waldron-Lynch, Frank, Wicker, Linda S., Todd, John A.

Publikováno v: In Clinical Immunology June 2017 179:25-39

Additional file 2: of The plasma biomarker soluble SIGLEC-1 is associated with the type I interferon transcriptional signature, ethnic background and renal disease in systemic lupus erythematosus

Autor: Oliveira, João, Karrar, Sarah, Rainbow, Daniel, Pinder, Christopher, Clarke, Pamela, García, Arcadio Rubio, Al-Assar, Osama, Burling, Keith, Morris, Sian, Stratton, Richard, Vyse, Tim, Wicker, Linda, Todd, John, Ferreira, Ricardo

Figure S1. Concentration of IFN-αb2 is associated with the IFN transcriptional signature. Data depict correlation between plasma IFN-αb2 concentration and transcriptional IFN signature in 41 SLE patients from cohort 2. (PDF 35 kb)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db687a31c9e0c3306aae98fd6fb31f3

Human IL-6R(hi)TIGIT(-) CD4(+)CD127(low)CD25(+) T cells display potent in vitro suppressive capacity and a distinct Th17 profile

Autor: Ferreira, Ricardo C., Rainbow, Daniel B., García, Arcadio Rubio, Pekalski, Marcin L., Porter, Linsey, Oliveira, João J., Waldron-Lynch, Frank, Wicker, Linda S., Todd, John A.

To date many clinical studies aim to increase the number and/or fitness of CD4⁺CD127$^{low}$CD25⁺ regulatory T cells (Tregs) in vivo to harness their regulatory potential in the context of treating autoimmune disease. Here, we sought to define th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d77fcf6828457ebc9a6fb0fd92568d9

Novel variation and de novo mutation rates in population-wide de novo assembled Danish trios

Autor: Besenbacher, Søren, Liu, Siyang, Gonzalez-Izarzugaza, Jose Maria, Grove, Jakob, Belling, Kirstine C., Bork-Jensen, Jette, Huang, Shujia, Dam-Als, Thomas, Li, Shengting, Yadav, Rachita, Rubio García, Arcadio, Lescai, Francesco, Demontis, Ditte, Rao, Junhua, Ye, Weijian, Mailund, Thomas, Friborg, Rune M., Pedersen, Christian N. S., Xu, Ruiqi, Sun, Jihua, Liu, Hao, Wang, Ou, Cheng, Xiaofang, Flores Santa Cruz, David, Rydza, Emil Karol, Rapacki, Kristoffer, Sørensen, John Damm, Chmura, Piotr Jaroslaw, Westergaard, David, Dworzynski, Piotr, Sørensen, Thorkild I. A., Lund, Ole, Hansen, Torben, Xu, Xun, Li, Ning, Bolund, Lars, Pedersen, Oluf, Eiberg, Hans, Krogh, Anders, Børglum, Anders D., Brunak, Søren, Kristiansen, Karsten, Schierup, Mikkel H, Jun, Wang, Gupta, Ramneek, Villesen, Palle, Rasmussen, Simon

Publikováno v: Besenbacher, S, Liu, S, Gonzalez-Izarzugaza, J M, Grove, J, Belling, K G, Bork-Jensen, J, Huang, S, Als, T D, Li, S, Yadav, R, Rubio García, A, Lescai, F, Demontis, D, Rao, J, Ye, W, Mailund, T, Møllegaard Friborg, R, Pedersen, C N S, Xu, R, Sun, J, Liu, H, Wang, O, Cheng, X, Flores, D, Rydza, E K, Rapacki, K, Sørensen, J D, Chmura, P J, Westergaard, D, Dworzynski, P, Sørensen, T I A, Lund, O, Hansen, T, Xu, X, Li, N, Bolund, L, Pedersen, O, Eiberg, H, Krogh, A, Børglum, A D, Brunak, S, Kristiansen, K, Schierup, M H, Wang, J, Gupta, R, Villesen, P & Rasmussen, S 2015, ' Novel variation and de novo mutation rates in population-wide de novo assembled Danish trios ', Nature Communications, vol. 6, 5969 . https://doi.org/10.1038/ncomms6969
Besenbacher, S, Liu, S, Izarzugaza, J M G, Grove, J, Belling, K, Bork-Jensen, J, Huang, S, Als, T D, Li, S, Yadav, R, Rubio-García, A, Lescai, F, Demontis, D, Rao, J, Ye, W, Mailund, T, Møllegaard Friborg, R, Pedersen, C N S, Xu, R, Sun, J, Liu, H, Wang, O, Cheng, X, Flores, D, Rydza, E, Rapacki, K, Damm Sørensen, J, Chmura, P, Westergaard, D, Dworzynski, P, Sørensen, T I A, Lund, O, Hansen, T, Xu, X, Li, N, Bolund, L, Pedersen, O, Eiberg, H, Krogh, A, Børglum, A D, Brunak, S, Kristiansen, K, Schierup, M H, Wang, J, Gupta, R, Villesen, P & Rasmussen, S 2015, ' Novel variation and de novo mutation rates in population-wide de novo assembled Danish trios ', Nature Communications, vol. 6, 5969 . https://doi.org/10.1038/ncomms6969
Besenbacher, S, Liu, S, Gonzalez-Izarzugaza, J M, Grove, J, Belling, K C, Bork-Jensen, J, Huang, S, Dam-Als, T, Li, S, Yadav, R, Yadav, R, Rubio García, A, Lescai, F, Demontis, D, Rao, J, Ye, W, Mailund, T, Friborg, R M, Pedersen, C N S, Xu, R, Sun, J, Liu, H, Wang, O, Cheng, X, Flores Santa Cruz, D, Rydza, E K, Rapacki, K, Sørensen, J D, Chmura, P J, Westergaard, D, Dworzynski, P, Sørensen, T I A, Lund, O, Hansen, T, Xu, X, Li, N, Bolund, L, Pedersen, O, Eiberg, H, Krogh, A, Børglum, A D, Brunak, S, Kristiansen, K, Schierup, M H, Jun, W, Gupta, R, Villesen, P & Rasmussen, S 2015, ' Novel variation and de novo mutation rates in population-wide de novo assembled Danish trios ', Nature Communications, vol. 6, 5969 . https://doi.org/10.1038/ncomms6969
Nature Communications
Besenbacher, S, Liu, S Y, Izarzugaza, J M G, Grove, J, Belling, K, Bork-Jensen, J, Huang, S J, Als, T D, Li, S T, Yadav, R, Rubio-Garcia, A, Lescai, F, Demontis, D, Rao, J H, Ye, W J, Mailund, T, Friborg, R M, Pedersen, C N S, Xu, R Q, Sun, J H, Liu, H, Wang, O, Cheng, X F, Flores, D, Rydza, E, Rapacki, K, Sorensen, J D, Chmura, P, Westergaard, D, Dworzynski, P, Sorensen, T I A, Lund, O, Hansen, T, Xu, X, Li, N, Bolund, L, Pedersen, O, Eiberg, H, Krogh, A, Borglum, A D, Brunak, S, Kristiansen, K, Schierup, M H, Wang, J, Gupta, R, Villesen, P & Rasmussen, S 2015, ' Novel variation and de novo mutation rates in population-wide de novo assembled Danish trios ', Nature Communications, vol. 6, 5969 . https://doi.org/10.1038/ncomms6969

Building a population-specific catalogue of single nucleotide variants (SNVs), indels and structural variants (SVs) with frequencies, termed a national pan-genome, is critical for further advancing clinical and public health genetics in large cohorts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8475aae7efa12ed5e8e3e337954c27fd
https://curis.ku.dk/portal/da/publications/novel-variation-and-de-novo-mutation-rates-in-populationwide-de-novo-assembled-danish-trios(ee4e61b1-1b7a-4713-a8bf-b6a584a85eaa).html