Rewiring of the cellular and inter-cellular landscape of the human colon during ulcerative colitis

Autor: Ashwin N. Ananthakrishnan, Orit Rozenblatt-Rosen, Jose Ordovas-Montanes, Sanja Vickovic, Matan Hofree, Lan T. Nguyen, Elizabeth A. Creasey, Malika Sud, Grace Burgin, Moshe Biton, Aviv Regev, Daniel B. Graham, Michal Slyper, Adam L. Haber, Julia Waldman, Mark J. Daly, Danielle Dionne, Garber Jj, Noga Rogel, Alexandra-Chloé Villani, Alex K. Shalek, Christopher Smillie, Desch An, Ramnik J. Xavier, Keri M. Sullivan, Rebecca H. Herbst, Hamed Khalili, Hongyan Huang, Elizabeth Andrews

Genome-wide association studies (GWAS) have revealed risk alleles for ulcerative colitis (UC), but their cell type and pathway specificities are often unknown. Here, we generate an atlas of 115,517 cells from the colon mucosa of seven UC patients and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a0228cef9c4db32929ddd72e6f282b9

Economic Burden of Eosinophilic Esophagitis: A Nationwide Cost-of-Illness Study.

Autor: Bozorg SR; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Division of Gastroenterology, Karolinska University Hospital, Stockholm, Sweden.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Söderling J; Clinical Epidemiology Division, Department of Medicine, Karolinska Institutet, Gothenburg, Sweden., Mårild K; Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg, Sweden.; Department of Pediatric Gastroenterology, Queen Silvia Children's Hospital, Gothenburg, Sweden., Garber JJ; Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Uchida A; Division of Gastroenterology, Hepatology and Nutrition, University of Utah School of Medicine, Salt Lake City, Utah, USA., Neovius M; Clinical Epidemiology Division, Department of Medicine, Karolinska Institutet, Gothenburg, Sweden., Ludvigsson JF; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden.; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA., Everhov ÅH; Clinical Epidemiology Division, Department of Medicine, Karolinska Institutet, Gothenburg, Sweden.; Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden .

Publikováno v: The American journal of gastroenterology [Am J Gastroenterol] 2024 Oct 01; Vol. 119 (10), pp. 2122-2125. Date of Electronic Publication: 2024 Mar 25.

An esophagus cell atlas reveals dynamic rewiring during active eosinophilic esophagitis and remission.

Autor: Ding J; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Department of Computer Science, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada., Garber JJ; Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA. garber.md@gmail.com.; Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. garber.md@gmail.com., Uchida A; Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA., Lefkovith A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Carter GT; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Vimalathas P; Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.; Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA., Canha L; Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA., Dougan M; Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA., Staller K; Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA., Yarze J; Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA., Delorey TM; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Rozenblatt-Rosen O; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Genentech, South San Francisco, CA, 94080, USA., Ashenberg O; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Graham DB; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.; Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA., Deguine J; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. aviv.regev.sc@gmail.com.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA. aviv.regev.sc@gmail.com.; Genentech, South San Francisco, CA, 94080, USA. aviv.regev.sc@gmail.com., Xavier RJ; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. xavier@molbio.mgh.harvard.edu.; Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. xavier@molbio.mgh.harvard.edu.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. xavier@molbio.mgh.harvard.edu.; Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. xavier@molbio.mgh.harvard.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Apr 18; Vol. 15 (1), pp. 3344. Date of Electronic Publication: 2024 Apr 18.

Eosinophilic esophagitis is associated with increased risk of later inflammatory bowel disease in a nationwide Swedish population cohort.

Autor: Uchida AM; Division of Gastroenterology, Hepatology & Nutrition, University of Utah School of Medicine, Salt Lake City, Utah, USA., Garber JJ; Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Pyne A; Division of Gastroenterology, Hepatology & Nutrition, University of Utah School of Medicine, Salt Lake City, Utah, USA., Peterson K; Division of Gastroenterology, Hepatology & Nutrition, University of Utah School of Medicine, Salt Lake City, Utah, USA., Roelstraete B; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Olén O; Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.; Sachs' Children and Youth Hospital, Stockholm South General Hospital, Stockholm, Sweden.; Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden., Halfvarson J; Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden., Ludvigsson JF; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Department of Pediatrics, Örebro University, Örebro, Sweden.; Department of Medicine, Celiac Disease Center, Columbia University College of Physicians and Surgeons, New York, New York, USA.

Publikováno v: United European gastroenterology journal [United European Gastroenterol J] 2024 Feb; Vol. 12 (1), pp. 34-43. Date of Electronic Publication: 2023 Dec 07.

Prior hospital-based infection and risk of eosinophilic esophagitis in a Swedish nationwide case-control study.

Autor: Uchida AM; Division of Gastroenterology, Hepatology & Nutrition, University of Utah School of Medicine, Salt Lake City, Utah, USA.; Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA.; Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Ro G; Division of Gastroenterology, Hepatology & Nutrition, University of Utah School of Medicine, Salt Lake City, Utah, USA.; Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA., Garber JJ; Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Roelstraete B; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Ludvigsson JF; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Department of Pediatrics, Örebro University, Örebro, Sweden.; Celiac Disease Center, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA.

Publikováno v: United European gastroenterology journal [United European Gastroenterol J] 2022 Nov; Vol. 10 (9), pp. 999-1007. Date of Electronic Publication: 2022 Oct 18.